Q96PD7 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03982 | DAGAT - Diacylglycerol acyltransferase | 92~388 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5203547 |  |
IC50 | = | 0.7 | nM | 541.55 | CC(n1c(=O)n(-c2cc(OC(F)F)ccc2F)c2ccc(C(=O)NC3(C)CS(=O)(=O)C3)cc21)C(C)(C)O | Homo sapiens | CHEMBL5126025 | cell membrane format |
| CHEMBL5179522 |  |
IC50 | = | 1.1 | nM | 569.6 | CC(n1c(=O)n(-c2cc(OC(F)F)ccc2F)c2ccc(C(=O)NC3(C)CCS(=O)(=O)CC3)cc21)C(C)(C)O | Homo sapiens | CHEMBL5126025 | cell membrane format |
| CHEMBL5188169 |  |
IC50 | = | 1.6 | nM | 551.61 | CC(n1c(=O)n(-c2cccc(OC(F)F)c2)c2ccc(C(=O)NC3(C)CCS(=O)(=O)CC3)cc21)C(C)(C)O | Homo sapiens | CHEMBL5126025 | cell membrane format |
| CHEMBL4107035 |  |
IC50 | = | 1.7 | nM | 459.47 | O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(OC(F)(F)F)c4)[nH]c3n2)C1)N1CCCC1 | Homo sapiens | CHEMBL3888181 | assay format |
| CHEMBL5184213 |  |
IC50 | = | 1.8 | nM | 531.51 | CC1(NC(=O)c2ccc3c(c2)n(-c2ccc(F)cc2)c(=O)n3-c2cccc(OC(F)F)c2)CS(=O)(=O)C1 | Homo sapiens | CHEMBL5126025 | cell membrane format |
| CHEMBL3734797 |  |
IC50 | = | 2.0 | nM | 571.6 | Cc1noc([C@H]2C[C@@H]2C(=O)NCc2ccc(-c3cccc(OC(F)(F)F)c3)c3c2CN(C(=O)NC(C)(C)C)CC3)n1 | Homo sapiens | CHEMBL3737415 | cell-based format |
| CHEMBL4868285 |  |
IC50 | = | 2.4 | nM | 456.45 | CCOc1cc(F)cnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CNCC[C@H]3F)cn2)c1 | Homo sapiens | CHEMBL4827630 | cell-based format |
| CHEMBL4114076 |  |
IC50 | = | 2.71 | nM | 438.6 | CC(C)Cc1csc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 | Homo sapiens | CHEMBL3888181 | assay format |
| CHEMBL3734847 |  |
IC50 | = | 3.0 | nM | 517.63 | COc1cccc(-c2ccc(CNC(=O)[C@H]3C[C@@H]3c3nc(C)no3)c3c2CCN(C(=O)NC(C)(C)C)C3)c1 | Homo sapiens | CHEMBL3737415 | cell-based format |
| CHEMBL4106571 |  |
IC50 | = | 3.18 | nM | 438.6 | CC(C)(C)c1csc(-c2nc3ccc(N4CCC[C@@H](C(=O)N5CCCC5)C4)nc3[nH]2)n1 | Homo sapiens | CHEMBL3888181 | assay format |
| CHEMBL4114492 |  |
IC50 | = | 3.58 | nM | 414.51 | O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(C5CC5)n4)[nH]c3n2)C1)N1CC=CC1 | Homo sapiens | CHEMBL3888181 | assay format |
| CHEMBL4845799 |  |
IC50 | = | 3.8 | nM | 502.48 | CCOc1cc(F)cnc1Oc1cncc(-c2ncc(C(=O)N[C@H]3CNCC[C@@H]3F)cn2)c1.O=CO | Homo sapiens | CHEMBL4827630 | cell-based format |
| CHEMBL3734764 |  |
IC50 | = | 4.0 | nM | 511.67 | COc1cccc(-c2ccc(CNC(=O)[C@@H]3C[C@H]3c3ccccc3)c3c2CCN(C(=O)NC(C)(C)C)C3)c1 | Homo sapiens | CHEMBL3737415 | cell-based format |
| CHEMBL4877520 |  |
IC50 | = | 4.1 | nM | 456.45 | CCOc1cc(F)cnc1Oc1cncc(-c2ncc(C(=O)N[C@@H]3CNC[C@@H](F)C3)cn2)c1 | Homo sapiens | CHEMBL4827630 | cell-based format |
| CHEMBL5425575 |  |
IC50 | = | 4.4 | nM | 488.47 | CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@H]3CC[C@@H](C(F)(F)F)NC3)cn2)c1 | Homo sapiens | CHEMBL5373985 | single protein format |
| CHEMBL4112256 |  |
IC50 | = | 4.56 | nM | 409.92 | O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(Cl)c4)[nH]c3n2)C1)N1CCCC1 | Homo sapiens | CHEMBL3888181 | assay format |
| CHEMBL4114844 |  |
IC50 | = | 4.82 | nM | 441.54 | O=C([C@@H]1CCCN(c2ccc3nc(-c4cccc(-n5cccn5)c4)[nH]c3n2)C1)N1CCCC1 | Homo sapiens | CHEMBL3888181 | assay format |
| CHEMBL4109153 |  |
IC50 | = | 5.27 | nM | 487.6 | CCOC(=O)C1(c2cccc(-c3nc4ccc(N5CCC[C@@H](C(=O)N6CCCC6)C5)nc4[nH]3)c2)CC1 | Homo sapiens | CHEMBL3888181 | assay format |
| CHEMBL4115482 |  |
IC50 | = | 5.68 | nM | 483.54 | O=C([C@@H]1CCCN(c2ccc3nc(C4(c5ccc(C(F)(F)F)cc5)CC4)[nH]c3n2)C1)N1CCCC1 | Homo sapiens | CHEMBL3888181 | assay format |
| CHEMBL4113426 |  |
IC50 | = | 6.32 | nM | 435.51 | O=C([C@@H]1CCCN(c2nc3[nH]c(-c4ccnc(C5CC5)n4)nc3cc2F)C1)N1CCCC1 | Homo sapiens | CHEMBL3888181 | assay format |