Q96P20 | NLRP3_HUMAN | NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Pfam Domain Table

AccessionDomainRangeColor
PF02758PYRIN - PAAD/DAPIN/Pyrin domain10~85
PF05729NACHT - NACHT domain220~389
PF13516LRR_6 - Leucine Rich repeat740~762
PF13516LRR_6 - Leucine Rich repeat796~819
PF13516LRR_6 - Leucine Rich repeat854~873
PF13516LRR_6 - Leucine Rich repeat910~933
PF13516LRR_6 - Leucine Rich repeat968~990
PF14484FISNA - Fish-specific NACHT associated domain140~210
PF17776NLRC4_HD2 - NLRC4 helical domain HD2522~644
PF17779NOD2_WH - NOD2 winged helix domain466~520

3D structures mapped by conservation among orthologs

[ Domain: "DEATH domain" // PYRIN ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5419955 IC50 = 0.07 nM 394.54 Cc1cc(NC2CCCN(C3CCC3)C2)nnc1-c1ccc2sccc2c1O Homo sapiens CHEMBL5392121 cell-based format
CHEMBL5408007 IC50 = 0.15 nM 422.49 CC(C)OC(=O)[C@@H](Cn1cc(C#N)cn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 Homo sapiens CHEMBL5374758 cell-based format
CHEMBL5429355 IC50 = 0.3 nM 462.02 CC(C)c1nn(CC(=O)N[C@@H]2CCCN(C3CCC3)C2)c(=O)c2cc3sc(Cl)cc3n12 Homo sapiens CHEMBL5392134 cell-based format
CHEMBL5409389 IC50 = 0.32 nM 409.49 CC(C)OC(=O)[C@@H](Cc1ncccn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 Homo sapiens CHEMBL5374758 cell-based format
CHEMBL5435222 IC50 = 0.38 nM 338.46 Cc1cc(N[C@@H]2CCCN(C)C2)nnc1-c1ccc(C2CC2)cc1O Homo sapiens CHEMBL5392139 cell-based format
CHEMBL5414596 IC50 = 0.4 nM 420.36 CN1CCC[C@@H](Nc2cc(C(F)(F)F)c(-c3ccc(C(F)(F)F)cc3O)nn2)C1 Homo sapiens CHEMBL5392112 cell-based format
CHEMBL5422139 IC50 = 0.4 nM 386.88 CCN1CCC[C@@H](Nc2nc3nc(-c4c(C)cc(Cl)cc4O)ccc3o2)C1 Homo sapiens CHEMBL5363651 cell-based format
CHEMBL5426651 IC50 = 0.4 nM 366.39 Cc1cc(N[C@@H]2CCCN(C)C2)nnc1-c1ccc(C(F)(F)F)cc1O Homo sapiens CHEMBL5392112 cell-based format
CHEMBL5425624 IC50 = 0.5 nM 500.91 CCN1CCC[C@H](Nc2nc3nc(-c4c(C)cc(Cl)cc4O)ccc3o2)C1.O=C(O)C(F)(F)F Homo sapiens CHEMBL5363651 cell-based format
CHEMBL5438834 IC50 = 0.5 nM 390.37 Cc1nc(NC(C)c2cccc(O)c2)nnc1-c1ccc(C(F)(F)F)cc1O Homo sapiens CHEMBL5392141 cell-based format
CHEMBL5408740 IC50 = 0.5 nM 398.89 Cc1cc(Cl)cc(O)c1-c1ccc2oc(N3CC[C@H]4CCN(C)C[C@H]43)nc2n1 Homo sapiens CHEMBL5363651 cell-based format
CHEMBL5403928 IC50 = 0.56 nM 409.49 CC(C)OC(=O)[C@@H](Cc1cnccn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 Homo sapiens CHEMBL5374758 cell-based format
CHEMBL5423228 IC50 = 0.58 nM 398.46 CC(C)OC(=O)[C@@H](Cn1cncn1)OC(=O)Nc1c2c(cc3c1CCC3)CCC2 Homo sapiens CHEMBL5374758 cell-based format
CHEMBL5395866 IC50 = 0.6 nM 398.89 Cc1cc(Cl)cc(O)c1-c1ccc2oc(N[C@H]3CCCN4CCC[C@H]34)nc2n1 Homo sapiens CHEMBL5363651 cell-based format
CHEMBL5395560 IC50 = 0.6 nM 518.9 CCN1CCC[C@H](Nc2nc3nc(-c4c(C)cc(Cl)c(F)c4O)ccc3o2)C1.O=C(O)C(F)(F)F Homo sapiens CHEMBL5363651 cell-based format
CHEMBL5401306 IC50 = 0.6 nM 444.92 COC(=O)CCN1CCC[C@H](Nc2nc3nc(-c4c(C)cc(Cl)cc4O)ccc3o2)C1 Homo sapiens CHEMBL5363651 cell-based format
CHEMBL5427865 IC50 = 0.62 nM 435.52 O=C(Nc1c2c(cc3c1CCC3)CCC2)O[C@H](Cc1ncccn1)C(=O)OC1CCCC1 Homo sapiens CHEMBL5374758 cell-based format
CHEMBL5422375 IC50 = 0.79 nM 381.35 C[C@]1(O)C[C@@H](Nc2nnc(-c3ccc(C(F)(F)F)cc3O)c3c2COC3)C1 Homo sapiens CHEMBL5392138 cell-based format
CHEMBL5417431 IC50 = 0.8 nM 380.41 CCN1CCC[C@H](Nc2ccc(-c3c(C)cc(C(F)(F)F)cc3O)nn2)C1 Homo sapiens CHEMBL5392112 cell-based format
CHEMBL5431540 IC50 = 0.843 nM 394.4 CN1CCC[C@@H](Nc2nnc(-c3ccc(C(F)(F)F)cc3O)c3c2COC3)C1 Homo sapiens CHEMBL5392138 cell-based format