Q96NT5 | PCFT_HUMAN | Proton-coupled folate transporter (SLC46A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07690 | MFS_1 - Major Facilitator Superfamily | 91~405 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4445651 |  |
IC50 | = | 1.5 | nM | 465.46 | Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309287 | cell-based format |
| CHEMBL1834488 |  |
IC50 | = | 3.34 | nM | 447.47 | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3387475 | cell-based format |
| CHEMBL4538151 |  |
IC50 | = | 3.82 | nM | 459.43 | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309287 | cell-based format |
| CHEMBL3628344 |  |
IC50 | = | 5.39 | nM | 447.47 | Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3632256 | cell-based format |
| CHEMBL4465095 |  |
IC50 | = | 6.0 | nM | 479.49 | Nc1nc2[nH]c(CCCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309287 | cell-based format |
| CHEMBL3628346 |  |
IC50 | = | 6.51 | nM | 447.47 | Nc1nc2[nH]c(CCCc3cc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cs3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3632256 | cell-based format |
| CHEMBL225072 |  |
IC50 | = | 13.2 | nM | 427.42 | Nc1nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3387475 | cell-based format |
| CHEMBL192632 |  |
IC50 | = | 23.0 | nM | 441.44 | Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309287 | cell-based format |
| CHEMBL4540298 |  |
IC50 | = | 23.0 | nM | 473.46 | Nc1nc2[nH]c(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309287 | cell-based format |
| CHEMBL2158681 |  |
IC50 | = | 41.5 | nM | 461.5 | Nc1nc2[nH]c(CCCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309287 | cell-based format |
| CHEMBL590740 |  |
IC50 | = | 43.4 | nM | 461.5 | Nc1nc2[nH]c(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL3412692 | cell-based format |
| CHEMBL4435608 |  |
IC50 | = | 48.6 | nM | 470.44 | CN(Cc1cc2c(=O)[nH]c(N)nc2[nH]1)C(=O)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 | Homo sapiens | CHEMBL4410582 | cell-based format |
| CHEMBL1201746 |  |
IC50 | = | 57.0 | nM | 477.48 | C#CCC(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 | Homo sapiens | CHEMBL4194632 | cell-based format |
| CHEMBL3409336 |  |
IC50 | = | 57.4 | nM | 475.53 | Nc1nc2[nH]cc(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3412692 | cell-based format |
| CHEMBL4447805 |  |
IC50 | = | 57.5 | nM | 443.42 | Nc1nc2[nH]c(CCOc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4432144 | cell-based format |
| CHEMBL4214638 |  |
IC50 | = | 57.6 | nM | 456.46 | Nc1nc2[nH]c(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)nc3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4194632 | cell-based format |
| CHEMBL4557278 |  |
IC50 | = | 67.0 | nM | 474.45 | Nc1nc2[nH]c(CCCCc3cnc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4309287 | cell-based format |
| CHEMBL3407519 |  |
IC50 | = | 80.2 | nM | 433.45 | Nc1nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3412692 | cell-based format |
| CHEMBL4761741 |  |
IC50 | = | 80.45 | nM | 464.53 | Nc1nc2sc(CCCc3cc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cs3)cc2c(=O)[nH]1 | Homo sapiens | CHEMBL4714600 | cell-based format |
| CHEMBL4444011 |  |
IC50 | = | 81.7 | nM | 484.47 | CC(=O)N(CCc1cc2c(=O)[nH]c(N)nc2[nH]1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 | Homo sapiens | CHEMBL4432144 | cell-based format |