Q96LA8 | ANM6_HUMAN | Protein arginine N-methyltransferase 6 (PRMT6)

Pfam Domain Table

AccessionDomainRangeColor
PF13649Methyltransf_25 - Methyltransferase domain86~182
PF22528PRMT_C - Arginine methyltransferase oligomerization subdomain188~364

3D structures mapped by conservation among orthologs

[ Domain: "Arginine methyltransferase oligomerization subdomain" // PRMT5_C_1 ]

 PyMOL session

[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // PrmA ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4094513 IC50 = 1.2 nM 306.86 CN(CCN)Cc1ccccc1Sc1ccccc1Cl Homo sapiens CHEMBL4026504 single protein format
CHEMBL3589043 IC50 = 2.0 nM 407.52 CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2cccc(C(=O)N(C)C)c2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589029 IC50 = 2.0 nM 322.41 CN(CCN)Cc1cn[nH]c1-c1ccc(Oc2ccccc2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589042 IC50 = 3.0 nM 407.52 CNCCN(C)Cc1c[nH]nc1-c1ccc(Oc2cccc(C(=O)N(C)C)c2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3901808 IC50 = 4.0 nM 287.41 CC(C)Oc1ccc(-c2c[nH]cc2CN(C)CCN)cc1 Homo sapiens CHEMBL3859040 single protein format
CHEMBL3590417 IC50 = 5.0 nM 393.49 CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2ccccc2C(=O)NC)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589026 IC50 = 7.0 nM 288.4 CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589030 IC50 = 8.0 nM 322.84 CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1Cl Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589028 IC50 = 10.0 nM 286.42 CC(C)Cc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589031 IC50 = 10.0 nM 336.87 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)c(Cl)c1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589039 IC50 = 10.0 nM 442.6 CNCCN(C)Cc1c[nH]nc1-c1ccc(O[C@H]2C[C@H](OCCC3CCOCC3)C2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589027 IC50 = 11.0 nM 302.42 CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589912 IC50 = 11.0 nM 248.31 CN(CCN)Cc1cn[nH]c1-c1ccc(F)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589040 IC50 = 13.0 nM 373.5 CN(CCN)Cc1c[nH]nc1-c1ccc(OCCCN2CCOCC2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL4463793 IC50 = 18.0 nM 298.39 C=CC(=O)Nc1cccc(-c2c[nH]cc2CN(C)CCN)c1 Homo sapiens CHEMBL4346578 single protein format
CHEMBL3589041 IC50 = 20.0 nM 432.57 CN(CCN)Cc1c[nH]nc1-c1ccc(N2CCN(C(=O)Cc3ccccc3)CC2)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3589032 IC50 = 23.0 nM 350.89 CNCCN(C)Cc1cnn(C)c1-c1ccc(OC(C)C)c(Cl)c1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3906680 IC50 = 25.0 nM 327.27 CNCCN1CCC(OCc2ccccc2Br)CC1 Homo sapiens CHEMBL3859043 assay format
CHEMBL3589913 IC50 = 25.0 nM 288.4 CCOc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 Homo sapiens CHEMBL3591482 cell-based format
CHEMBL3956007 IC50 = 25.0 nM 342.49 CNCCN1CCC(OCc2ccc(-n3nc(C)cc3C)cc2)CC1 Homo sapiens CHEMBL3859043 assay format