Q96L73 | NSD1_HUMAN | Histone-lysine N-methyltransferase, H3 lysine-36 specific (NSD1)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00628 | PHD | 1710–1748 | |
| PF00855 | PWWP | 324–408 | |
| PF00855 | PWWP | 1758–1845 | |
| PF00856 | SET | 1953–2059 | |
| PF17907 | AWS | 1901–1939 | |
| PF17982 | C5HCH | 2161–2210 | |
| PF22908 | PHD_NSD | 1590–1638 | |
| PF23004 | PHDvar_NSD | 1643–1692 | |
| PF23011 | PHD-1st_NSD | 1539–1587 |
3D structures mapped by conservation among orthologs
[ Domain: "SET domain-like" // SET ]
[ Domain: "Zn3Cys9 preSET domain-related" // AWS ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL337173 |  |
IC50 | = | 150.0 | nM | 321.76 | O=C1C(Cl)=C(NCCN2CCOCC2)C(=O)c2ncccc21 | Homo sapiens | CHEMBL5318866 | single protein format |
| CHEMBL5408212 |  |
IC50 | = | 160.0 | nM | 480.52 | COC[C@@]1(N)CCCN(c2cnc(-c3ccc(F)c(F)c3)cc2Cn2cnc3c(N)ncnc32)C1 | Homo sapiens | CHEMBL5364867 | single protein format |
| CHEMBL5438312 |  |
IC50 | = | 214.0 | nM | 506.56 | Nc1ncnc2c1ncn2Cc1cc(-c2ccc(F)c(F)c2)ncc1N1CCC[C@](N)(COC2CC2)C1 | Homo sapiens | CHEMBL5364867 | single protein format |
| CHEMBL5419719 |  |
IC50 | = | 225.0 | nM | 480.52 | COC[C@@]1(N)CCCN(c2cnc(-c3ccc(F)cc3F)cc2Cn2cnc3c(N)ncnc32)C1 | Homo sapiens | CHEMBL5364867 | single protein format |
| CHEMBL5396709 |  |
IC50 | = | 248.0 | nM | 496.98 | COC[C@@]1(N)CCCN(c2cnc(-c3cc(Cl)ccc3F)cc2Cn2cnc3c(N)ncnc32)C1 | Homo sapiens | CHEMBL5364867 | single protein format |
| CHEMBL5432302 |  |
IC50 | = | 270.0 | nM | 532.62 | COc1ccc(-c2cc(Cn3cnc4c(N)ncnc43)c(N3CCC[C@](N)(COC4CCC4)C3)cn2)cc1F | Homo sapiens | CHEMBL5364867 | single protein format |
| CHEMBL5422549 |  |
IC50 | = | 690.0 | nM | 355.78 | CC#CC(=O)NC12CC(NC3=C(Cl)C(=O)c4ncccc4C3=O)(C1)C2 | Homo sapiens | CHEMBL5318866 | single protein format |