Q96L34 | MARK4_HUMAN | MAP/microtubule affinity-regulating kinase 4 (MARK4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 59~310 | |
| PF00627 | UBA - UBA/TS-N domain | 331~366 | |
| PF02149 | KA1 - Kinase associated domain 1 | 712~752 |
3D structures mapped by conservation among orthologs
[ Domain: "RuvA-C, UBA, CRAL/TRIO-N, HBS1" // UBA_MELK ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 0.114 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328486 | single protein format |
| CHEMBL5305160 |  |
IC50 | = | 2.0 | nM | 469.59 | CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3cccc(CN4CCCC4)c3)ncc21 | Homo sapiens | CHEMBL5345920 | single protein format |
| CHEMBL3884319 |  |
IC50 | = | 21.0 | nM | 386.45 | CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21 | Homo sapiens | CHEMBL3876024 | cell-based format |
| CHEMBL5085430 |  |
IC50 | = | 72.0 | nM | 516.44 | O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br)C1CCC1 | Homo sapiens | CHEMBL5046588 | cell-based format |
| CHEMBL3884344 |  |
IC50 | = | 180.0 | nM | 463.56 | CC1(C)C(=O)N([C@H]2CCc3c(NS(C)(=O)=O)cccc32)c2nc(Nc3ccccc3)ncc21 | Homo sapiens | CHEMBL3876024 | cell-based format |
| CHEMBL5088930 |  |
IC50 | = | 214.0 | nM | 458.36 | Brc1cnc(Nc2cccc(CN3CCOCC3)c2)nc1NCCc1c[nH]cn1 | Homo sapiens | CHEMBL5046588 | cell-based format |
| CHEMBL3884318 |  |
IC50 | = | 270.0 | nM | 375.43 | C[C@@H](c1cccc(O)c1)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 | Homo sapiens | CHEMBL3876024 | cell-based format |
| CHEMBL3605057 |  |
IC50 | = | 319.0 | nM | 464.61 | O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1 | Homo sapiens | CHEMBL5046588 | cell-based format |
| CHEMBL3916849 |  |
IC50 | = | 338.0 | nM | 471.36 | O=C(Nc1cccc(Nc2ncc(Br)c(NCCc3cnc[nH]3)n2)c1)N1CCCC1 | Homo sapiens | CHEMBL5046588 | cell-based format |
| CHEMBL3883979 |  |
IC50 | = | 450.0 | nM | 385.47 | CC1(C)C(=O)N([C@H]2CCc3c(N)cccc32)c2nc(Nc3ccccc3)ncc21 | Homo sapiens | CHEMBL3876024 | cell-based format |
| CHEMBL5090046 |  |
IC50 | = | 509.0 | nM | 477.61 | O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1C1CC1)C1CCC1 | Homo sapiens | CHEMBL5046588 | cell-based format |
| CHEMBL3883433 |  |
IC50 | = | 520.0 | nM | 371.44 | CC1(C)C(=O)N([C@H]2CCc3ccccc32)c2nc(Nc3cccnc3)ncc21 | Homo sapiens | CHEMBL3876024 | cell-based format |
| CHEMBL5091688 |  |
IC50 | = | 808.0 | nM | 419.53 | c1cc(CN2CCOCC2)cc(Nc2ncc(C3CC3)c(NCCc3c[nH]cn3)n2)c1 | Homo sapiens | CHEMBL5046588 | cell-based format |
| CHEMBL3884535 |  |
IC50 | = | 920.0 | nM | 420.56 | CC1(C)C(=O)N(C2CCCCC2)c2nc(Nc3cccc(N4CCNCC4)c3)ncc21 | Homo sapiens | CHEMBL3876024 | cell-based format |