Q96KS0 | EGLN2_HUMAN | Prolyl hydroxylase EGLN2 (EGLN2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF13640 | 2OG-FeII_Oxy_3 - 2OG-Fe(II) oxygenase superfamily | 283~374 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // 2OG-FeII_Oxy_3 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2041169 |  |
IC50 | = | 0.2 | nM | 586.66 | Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(-c4ccn[nH]4)cc3)cc1)C(=O)N2c1cc(O)ncn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041175 |  |
IC50 | = | 0.2 | nM | 577.67 | Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc4scnc4c3)cc1)C(=O)N2c1cc(O)ncn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2043325 |  |
IC50 | = | 0.2 | nM | 592.66 | COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041190 |  |
IC50 | = | 0.2 | nM | 562.63 | Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cnccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041193 |  |
IC50 | = | 0.2 | nM | 562.63 | Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ccncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2043169 |  |
IC50 | = | 0.2 | nM | 578.63 | COc1cc(N2C(=O)N(c3ccc(-c4cccc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041185 |  |
IC50 | = | 0.2 | nM | 592.66 | COc1nccnc1N1C(=O)N(c2ccc(-c3ccc(C(=O)O)cc3C)cc2)C(=O)C12CCN(Cc1ncccc1C)CC2 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041182 |  |
IC50 | = | 0.2 | nM | 576.66 | Cc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041178 |  |
IC50 | = | 0.3 | nM | 591.67 | CNC(=O)c1ccc(-c2ccc(N3C(=O)N(c4cc(OC)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)cc1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041184 |  |
IC50 | = | 0.3 | nM | 576.66 | Cc1nccc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)n1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2043168 |  |
IC50 | = | 0.3 | nM | 578.63 | COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2043326 |  |
IC50 | = | 0.3 | nM | 592.66 | COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)c(C)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041010 |  |
IC50 | = | 0.3 | nM | 584.66 | COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)s4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041192 |  |
IC50 | = | 0.3 | nM | 548.6 | Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1ccncn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041188 |  |
IC50 | = | 0.3 | nM | 562.63 | Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ncccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041186 |  |
IC50 | = | 0.3 | nM | 576.66 | Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3nccnc3C)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2043324 |  |
IC50 | = | 0.4 | nM | 596.62 | COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4F)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2040897 |  |
IC50 | = | 0.4 | nM | 555.66 | Cc1nc(C)c(-c2ccc(N3C(=O)N(c4cc(O)ncn4)C4(CCN(Cc5ncccc5C)CC4)C3=O)cc2)s1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2041189 |  |
IC50 | = | 0.4 | nM | 548.6 | Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc(C(=O)O)cc3)cc1)C(=O)N2c1cnccn1 | Homo sapiens | CHEMBL2045987 | single protein format |
| CHEMBL2040854 |  |
IC50 | = | 0.5 | nM | 579.62 | Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cc(O)ncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cn1 | Homo sapiens | CHEMBL2045987 | single protein format |