Q96KQ7 | EHMT2_HUMAN | Histone-lysine N-methyltransferase EHMT2 (EHMT2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00023 | Ank - Ankyrin repeat | 850~882 | |
| PF00856 | SET - SET domain | 1049~1155 | |
| PF05033 | Pre-SET - Pre-SET motif | 928~1030 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 655~741 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 748~815 | |
| PF21533 | EHMT1-2_CRR - Histone-lysine N-methyltransferase EHMT1/EHMT2, Cys-rich region | 446~538 |
3D structures mapped by conservation among orthologs
[ Domain: "SET domain-like" // SET ]
[ Domain: "Zn3Cys9 preSET domain-related" // Pre-SET ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5437232 |  |
IC50 | = | 0.42 | nM | 493.65 | CC#CC(=O)NCc1cc(NC2CCN(C)CC2)c2cc(OC)c(OCCCN3CCCC3)cc2n1 | Homo sapiens | CHEMBL5343786 | single protein format |
| CHEMBL5403007 |  |
IC50 | = | 0.49 | nM | 481.64 | C=CC(=O)NCc1cc(NC2CCN(C)CC2)c2cc(OC)c(OCCCN3CCCC3)cc2n1 | Homo sapiens | CHEMBL5343786 | single protein format |
| CHEMBL4170225 |  |
IC50 | = | 0.5 | nM | 477.65 | COc1cc2c(NC3CCN(C)CC3)cc(-c3ccc(C)[nH]3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4137466 | single protein format |
| CHEMBL5424749 |  |
IC50 | = | 0.52 | nM | 495.67 | C/C=C/C(=O)NCc1cc(NC2CCN(C)CC2)c2cc(OC)c(OCCCN3CCCC3)cc2n1 | Homo sapiens | CHEMBL5343786 | single protein format |
| CHEMBL5405913 |  |
IC50 | = | 0.53 | nM | 495.67 | C=C(C)C(=O)NCc1cc(NC2CCN(C)CC2)c2cc(OC)c(OCCCN3CCCC3)cc2n1 | Homo sapiens | CHEMBL5343786 | single protein format |
| CHEMBL4162206 |  |
IC50 | = | 0.7 | nM | 508.75 | COc1cc2c(NC3CCN(C(C)C)CC3)cc(C3CCCCC3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4137466 | single protein format |
| CHEMBL5416767 |  |
IC50 | = | 0.71 | nM | 483.66 | CCC(=O)NCc1cc(NC2CCN(C)CC2)c2cc(OC)c(OCCCN3CCCC3)cc2n1 | Homo sapiens | CHEMBL5343786 | single protein format |
| CHEMBL3109639 |  |
IC50 | = | 0.9 | nM | 317.43 | COc1cc2c(cc1OCCCN1CCCC1)N=C(N)C2(C)C | Homo sapiens | CHEMBL3111908 | single protein format |
| CHEMBL3109631 |  |
IC50 | = | 1.0 | nM | 315.42 | COc1cc2c(cc1OCC1CCN(C)C1)N=C(N)C21CCC1 | Homo sapiens | CHEMBL3111908 | single protein format |
| CHEMBL5187766 |  |
IC50 | = | 1.6 | nM | 344.46 | COc1cc2c(NCCN)ccnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5116773 | single protein format |
| CHEMBL5435285 |  |
IC50 | = | 1.7 | nM | 504.08 | COc1cc2c(NC3CCN(C)CC3)cc(CNC(=O)CCl)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5343786 | single protein format |
| CHEMBL5396581 |  |
IC50 | = | 1.8 | nM | 355.46 | Cc1cc(CNC(=O)C(c2ccc(F)cc2)N2CCCCC2)cnc1C | Homo sapiens | CHEMBL5392906 | cell-based format |
| CHEMBL1829295 |  |
IC50 | = | 2.0 | nM | 567.82 | COc1cc2c(NC3CCN(C(C)C)CC3)nc(N3CCCN(C(C)C)CC3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL1832317 | single protein format |
| CHEMBL4160008 |  |
IC50 | = | 2.0 | nM | 492.66 | CCc1ccc(-c2cc(NC3CCN(C)CC3)c3cc(OC)c(OCCCN4CCCC4)cc3n2)o1 | Homo sapiens | CHEMBL4137466 | single protein format |
| CHEMBL4159604 |  |
IC50 | = | 2.0 | nM | 480.7 | COc1cc2c(NC3CCN(C)CC3)cc(C3CCCCC3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4137466 | single protein format |
| CHEMBL5414343 |  |
IC50 | = | 2.1 | nM | 372.54 | Cc1cc(N2CCN(Cc3cc(CN4CCCC4)cs3)CC2)nc(N)n1 | Homo sapiens | CHEMBL5392906 | cell-based format |
| CHEMBL5195846 |  |
IC50 | = | 2.4 | nM | 301.39 | COc1cc2c(N)ccnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5116773 | single protein format |
| CHEMBL5433429 |  |
IC50 | = | 2.5 | nM | 321.81 | CCN1CC(NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](OC)C1 | Homo sapiens | CHEMBL5392906 | cell-based format |
| CHEMBL5410162 |  |
IC50 | = | 2.9 | nM | 556.66 | COc1cc2c(NCc3c(C)cc(C)[nH]c3=O)nc(N3CCC(F)(F)CC3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5340359 | single protein format |
| CHEMBL4173626 |  |
IC50 | = | 3.0 | nM | 520.72 | CCc1ccc(-c2cc(NC3CCN(C(C)C)CC3)c3cc(OC)c(OCCCN4CCCC4)cc3n2)o1 | Homo sapiens | CHEMBL4137466 | single protein format |