Q96KB5 | TOPK_HUMAN | Lymphokine-activated killer T-cell-originated protein kinase (PBK)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 35~316 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4445123 |  |
IC50 | = | 0.5 | nM | 358.44 | Cc1cc(O)c(-c2ccc([C@@H](C)CN)cc2)c2c1[nH]c(=O)c1ccccc12 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL4452726 |  |
IC50 | = | 1.56 | nM | 358.44 | Cc1ccc2c(=O)[nH]c3c(C)cc(O)c(-c4ccc([C@@H](C)N)cc4)c3c2c1 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL3672295 |  |
IC50 | = | 2.6 | nM | 364.47 | Cc1cc(O)c(-c2ccc([C@@H](C)CN)cc2)c2c1[nH]c(=O)c1sccc12 | Homo sapiens | CHEMBL4261716 | assay format |
| CHEMBL4440222 |  |
IC50 | = | 2.71 | nM | 364.83 | C[C@@H](N)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4ccccc4c23)cc1 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL4527920 |  |
IC50 | = | 2.94 | nM | 344.41 | Cc1cc(O)c(-c2ccc([C@@H](C)N)cc2)c2c1[nH]c(=O)c1ccccc12 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL4564624 |  |
IC50 | = | 4.59 | nM | 378.86 | C[C@@H](CN)c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4ccccc4c23)cc1 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL3715360 |  |
IC50 | = | 5.2 | nM | 411.54 | O=C(N[C@H]1CCCNC1)c1ccnc2nc(-c3ccc(N4CCNCC4)s3)[nH]c12 | Homo sapiens | CHEMBL3720934 | single protein format |
| CHEMBL3716544 |  |
IC50 | = | 5.3 | nM | 351.45 | NC12CC3CC(C1)CC(NC(=O)c1ccnc4[nH]c(C5CC5)nc14)(C3)C2 | Homo sapiens | CHEMBL3720934 | single protein format |
| CHEMBL4536593 |  |
IC50 | = | 5.44 | nM | 372.47 | COc1cc(C)c2[nH]c(=O)c3ccccc3c2c1-c1ccc([C@@H](C)CN)cc1 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL4452595 |  |
IC50 | = | 6.44 | nM | 372.47 | Cc1ccc2c(=O)[nH]c3c(C)cc(O)c(-c4ccc([C@@H](C)CN)cc4)c3c2c1 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL4537262 |  |
IC50 | = | 10.69 | nM | 400.93 | Cc1cc(O)c(-c2ccc([C@@H](C)CN)cc2)c2c1[nH]c(=O)c1sccc12.Cl | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL4469640 |  |
IC50 | = | 19.06 | nM | 400.52 | Cc1ccc2c(=O)[nH]c3c(C)cc(O)c(-c4ccc([C@@H](C)CN(C)C)cc4)c3c2c1 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL4455498 |  |
IC50 | = | 20.88 | nM | 386.5 | Cc1ccc2c(=O)[nH]c3c(C)cc(O)c(-c4ccc([C@@H](C)N(C)C)cc4)c3c2c1 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL4593398 |  |
IC50 | = | 21.0 | nM | 357.34 | FC(F)(F)c1n[nH]cc1-c1nc2ccc3[nH]ncc3c2c2c1CCCC2 | Homo sapiens | CHEMBL4360652 | single protein format |
| CHEMBL3672271 |  |
IC50 | = | 23.0 | nM | 350.44 | Cc1cc(O)c(-c2ccc([C@@H](C)N)cc2)c2c1[nH]c(=O)c1sccc12 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL3715388 |  |
IC50 | = | 24.0 | nM | 393.52 | NC12CC3CC(C1)CC(NC(=O)c1ccnc4nc(-c5cccs5)[nH]c14)(C3)C2 | Homo sapiens | CHEMBL3720934 | single protein format |
| CHEMBL4458265 |  |
IC50 | = | 25.1 | nM | 370.45 | Cc1cc(O)c(-c2ccc(C3(CN)CC3)cc2)c2c1[nH]c(=O)c1ccccc12 | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL4438486 |  |
IC50 | = | 26.13 | nM | 392.89 | C[C@H](c1ccc(-c2c(O)cc(Cl)c3[nH]c(=O)c4ccccc4c23)cc1)N(C)C | Homo sapiens | CHEMBL4384180 | single protein format |
| CHEMBL3672369 |  |
IC50 | = | 28.0 | nM | 392.52 | Cc1cc(O)c(-c2ccc([C@@H](C)CN(C)C)cc2)c2c1[nH]c(=O)c1sccc12 | Homo sapiens | CHEMBL4261716 | assay format |
| CHEMBL3716635 |  |
IC50 | = | 33.0 | nM | 299.38 | N[C@H]1CC[C@H](NC(=O)c2ccnc3[nH]c(C4CC4)nc23)CC1 | Homo sapiens | CHEMBL3720934 | single protein format |