Q96JM7 | LMBL3_HUMAN | Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00536 | SAM_1 - SAM domain (Sterile alpha motif) | 706~770 | |
| PF02820 | MBT - mbt repeat | 268~336 | |
| PF02820 | MBT - mbt repeat | 375~442 | |
| PF02820 | MBT - mbt repeat | 479~544 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // MBT ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3134130 |  |
IC50 | = | 37.0 | nM | 361.96 | Clc1cc(N2CCC(N3CCCC3)CC2)ccc1CCN1CCCC1 | Homo sapiens | CHEMBL3136684 | single protein format |
| CHEMBL2426365 |  |
IC50 | = | 39.0 | nM | 543.76 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(NCc2ccccc2)c1)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL3134144 |  |
IC50 | = | 48.0 | nM | 313.49 | c1cc(N2CCC(N3CCCC3)CC2)ccc1CCN1CCC1 | Homo sapiens | CHEMBL3136684 | single protein format |
| CHEMBL2426366 |  |
IC50 | = | 48.0 | nM | 528.74 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Cc2ccccc2)c1)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL2426367 |  |
IC50 | = | 58.0 | nM | 530.71 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Oc2ccccc2)c1)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL3134146 |  |
IC50 | = | 59.0 | nM | 373.54 | OCC1(CO)CN(CCc2ccc(N3CCC(N4CCCC4)CC3)cc2)C1 | Homo sapiens | CHEMBL3136684 | single protein format |
| CHEMBL3134131 |  |
IC50 | = | 62.0 | nM | 327.52 | c1cc(N2CCC(N3CCCC3)CC2)ccc1CCN1CCCC1 | Homo sapiens | CHEMBL3136684 | single protein format |
| CHEMBL2426364 |  |
IC50 | = | 64.0 | nM | 529.73 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Nc2ccccc2)c1)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL2426368 |  |
IC50 | = | 66.0 | nM | 514.71 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(-c2ccccc2)c1)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL3134134 |  |
IC50 | = | 70.0 | nM | 341.54 | c1cc(N2CCC(N3CCCC3)CC2)ccc1CCCN1CCCC1 | Homo sapiens | CHEMBL3136684 | single protein format |
| CHEMBL2426498 |  |
IC50 | = | 71.0 | nM | 438.62 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)cc1)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL2426360 |  |
IC50 | = | 72.0 | nM | 488.68 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c2ccccc12)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL3134126 |  |
IC50 | = | 80.0 | nM | 341.54 | c1cc(N2CCC(N3CCCC3)CC2)ccc1CCN1CCCCC1 | Homo sapiens | CHEMBL3136684 | single protein format |
| CHEMBL2426363 |  |
IC50 | = | 96.0 | nM | 444.65 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)s1)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL2426496 |  |
IC50 | = | 96.0 | nM | 452.64 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)cc1)N1CCCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL2426481 |  |
IC50 | = | 99.0 | nM | 474.67 | O=C(c1ccc(S(=O)(=O)N2CCC(N3CCCC3)CC2)cc1)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL3134125 |  |
IC50 | = | 100.0 | nM | 355.57 | c1cc(N2CCC(N3CCCC3)CC2)ccc1CCN1CCCCCC1 | Homo sapiens | CHEMBL3136684 | single protein format |
| CHEMBL2424678 |  |
IC50 | = | 110.0 | nM | 439.6 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)nc1)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL2426469 |  |
IC50 | = | 110.0 | nM | 466.67 | O=C(c1ccc(C(=O)N2CCCC(N3CCCC3)CC2)cc1)N1CCCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |
| CHEMBL2426476 |  |
IC50 | = | 120.0 | nM | 517.51 | O=C(c1ccc(C(=O)N2CCC(N3CCCC3)CC2)c(Br)c1)N1CCC(N2CCCC2)CC1 | Homo sapiens | CHEMBL2429079 | single protein format |