Q96GG9 | DCNL1_HUMAN | DCN1-like protein 1 (DCUN1D1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03556 | Cullin_binding - Cullin binding | 136~246 | |
| PF14555 | UBA_4 - UBA-like domain | 9~49 |
3D structures mapped by conservation among orthologs
[ Domain: "EF-hand" // Cullin_binding ]
[ Domain: "EF-hand" // KOG3077 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5075399 |  |
IC50 | = | 2.86 | nM | 521.63 | COc1cc(-c2nc(SCc3ccc(C)cc3)nc(Sc3nnnn3C)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5070367 |  |
IC50 | = | 5.36 | nM | 566.69 | COC(=O)c1ccc(CSc2nc(Sc3nccs3)c(C#N)c(-c3cc(OC)c(OC)c(OC)c3)n2)cc1 | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5091659 |  |
IC50 | = | 5.48 | nM | 522.68 | COc1cc(-c2nc(SCc3cccc(C)c3)nc(Sc3nccs3)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5092564 |  |
IC50 | = | 6.15 | nM | 557.66 | COc1cc(-c2nc(SCc3ccc4ccccc4c3)nc(Sc3nnnn3C)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5086499 |  |
IC50 | = | 9.37 | nM | 578.72 | COc1cc(-c2nc(SCc3ccc(C)cc3)nc(Sc3nnnn3CCN(C)C)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5085822 |  |
IC50 | = | 9.55 | nM | 542.05 | COc1cc(-c2nc(SCc3ccc(Cl)cc3)nc(Sc3nnnn3C)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5082310 |  |
IC50 | = | 11.07 | nM | 521.63 | COc1cc(-c2nc(SCc3cccc(C)c3)nc(Sc3nnnn3C)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5078162 |  |
IC50 | = | 11.48 | nM | 564.76 | COc1cc(-c2nc(SCc3ccc(C(C)(C)C)cc3)nc(Sc3nccs3)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5091608 |  |
IC50 | = | 12.4 | nM | 578.72 | COc1cc(-c2nc(SCc3cccc(C)c3)nc(Sc3nnnn3CCN(C)C)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5085047 |  |
IC50 | = | 13.41 | nM | 594.72 | COc1ccc(CSc2nc(Sc3nnnn3CCN(C)C)c(C#N)c(-c3cc(OC)c(OC)c(OC)c3)n2)cc1 | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5074683 |  |
IC50 | = | 17.14 | nM | 492.65 | COc1ccc(-c2nc(SCc3ccc(C)cc3)nc(Sc3nccs3)c2C#N)cc1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL4067795 |  |
IC50 | = | 18.0 | nM | 429.61 | CCCC(C)N1CCC(N(Cc2ccccc2)C(=O)Nc2ccc3ccccc3c2)CC1 | Homo sapiens | CHEMBL4024549 | single protein format |
| CHEMBL4851208 |  |
IC50 | = | 20.82 | nM | 585.82 | CCC(=O)N[C@@H](Cc1nc2ccc(C(C)C)cc2s1)C(=O)N[C@@H](CNC(=O)CCN1CCOCC1)C1CCCCC1 | Homo sapiens | CHEMBL4817609 | assay format |
| CHEMBL4517307 |  |
IC50 | = | 20.82 | nM | 585.82 | CCC(=O)N[C@@H](Cc1nc2ccc(C(C)C)cc2s1)C(=O)N[C@H](CNC(=O)CCN1CCOCC1)C1CCCCC1 | Homo sapiens | CHEMBL4398582 | assay format |
| CHEMBL5089944 |  |
IC50 | = | 20.88 | nM | 446.63 | Cc1ccc(CSc2nc(Sc3nccs3)c(C#N)c(-c3ccc(C)cc3)n2)cc1 | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5089246 |  |
IC50 | = | 21.17 | nM | 462.63 | COc1ccc(-c2nc(SCc3ccc(C)cc3)nc(Sc3nccs3)c2C#N)cc1 | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5080691 |  |
IC50 | = | 24.74 | nM | 543.1 | COc1cc(-c2nc(SCc3ccc(Cl)cc3)nc(Sc3nccs3)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5089086 |  |
IC50 | = | 25.31 | nM | 599.14 | COc1cc(-c2nc(SCc3ccc(Cl)cc3)nc(Sc3nnnn3CCN(C)C)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL5087586 |  |
IC50 | = | 25.77 | nM | 575.6 | COc1cc(-c2nc(SCc3cccc(C(F)(F)F)c3)nc(Sc3nnnn3C)c2C#N)cc(OC)c1OC | Homo sapiens | CHEMBL5043811 | single protein format |
| CHEMBL4592844 |  |
IC50 | = | 26.89 | nM | 380.52 | C#CCSc1nc(Sc2nccs2)c(C#N)c(-c2ccc(C)cc2)n1 | Homo sapiens | CHEMBL4398582 | assay format |