Q96GD4 | AURKB_HUMAN | Aurora kinase B (AURKB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 77~327 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3680444 |  |
IC50 | = | 0.042 | nM | 428.45 | COc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cn1 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3680508 |  |
IC50 | = | 0.045 | nM | 455.4 | NC(=O)c1cccc2c(NCc3ccc(NC(=O)c4cc(C(F)(F)F)n[nH]4)cc3)ncnc12 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3680447 |  |
IC50 | = | 0.046 | nM | 482.59 | CCN(CC)c1ccc(C(=O)Nc2cccc(C(C)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3680552 |  |
IC50 | = | 0.06 | nM | 395.43 | N#Cc1ccnc(Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c1 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3685243 |  |
IC50 | = | 0.061 | nM | 411.47 | Cc1cccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c1 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3685277 |  |
IC50 | = | 0.089 | nM | 427.47 | NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cc(C5CC5)n[nH]4)c3)ncnc12 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3675525 |  |
IC50 | = | 0.17 | nM | 485.44 | NC(=O)c1cccc2c(NCc3cccc(NC(O)c4cc(C(F)(F)F)ccc4F)c3)ncnc12 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3680596 |  |
IC50 | = | 0.18 | nM | 409.45 | N#CCc1ccnc(Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c1 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3685262 |  |
IC50 | = | 0.18 | nM | 431.88 | NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)cc4)c3)ncnc12 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL1940103 |  |
IC50 | < | 0.2 | nM | 422.42 | COc1cc2ncnc(Nc3cnn(CC(=O)Nc4cccc(F)c4)c3)c2cc1OC | Homo sapiens | CHEMBL1942923 | single protein format |
| CHEMBL3639841 |  |
IC50 | = | 0.2 | nM | 477.43 | NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc5c(c4)OC(F)(F)O5)c3)ncnc12 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3685245 |  |
IC50 | = | 0.21 | nM | 483.43 | NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(C(F)(F)F)cc4F)c3)ncnc12 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3685306 |  |
IC50 | = | 0.22 | nM | 463.44 | COc1cc(F)c(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c(F)c1 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3670499 |  |
IC50 | = | 0.24 | nM | 362.31 | NC(=O)c1cc(O)cc2c(NCc3ccc(C(F)(F)F)cc3)ncnc12 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3675441 |  |
IC50 | = | 0.25 | nM | 433.42 | NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(F)cc4F)c3)ncnc12 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3680500 |  |
IC50 | = | 0.26 | nM | 427.47 | CNc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cn1 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3680420 |  |
IC50 | = | 0.27 | nM | 443.51 | CC(C)c1cc(C(=O)Nc2cccc(C(C)Nc3ncnc4c(C(N)=O)cccc34)c2)[nH]n1 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL4455202 |  |
IC50 | = | 0.29 | nM | 528.46 | CC1(C)CC(NC(=O)c2ccc(Nc3ncc(Cl)c(Nc4ccccc4Cl)n3)cc2)CC(C)(C)N1[O] | Homo sapiens | CHEMBL4311509 | single protein format |
| CHEMBL3680403 |  |
IC50 | = | 0.3 | nM | 466.33 | NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)c(Cl)c4)c3)ncnc12 | Homo sapiens | CHEMBL3707758 | single protein format |
| CHEMBL3680554 |  |
IC50 | = | 0.3 | nM | 441.5 | NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4[nH]nc5c4CCCC5)c3)ncnc12 | Homo sapiens | CHEMBL3707758 | single protein format |