Q96DB2 | HDA11_HUMAN | Histone deacetylase 11 (HDAC11)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00850 | Hist_deacetyl - Histone deacetylase domain | 35~316 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL343448 |  |
IC50 | = | 0.3 | nM | 540.71 | C/C=C1\NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O | Homo sapiens | CHEMBL3366360 | single protein format |
| CHEMBL3310505 |  |
IC50 | = | 0.3 | nM | 540.71 | C/C=C1\NC(=O)[C@H]2CSSCC/C=C/[C@@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O | Homo sapiens | CHEMBL4771534 | single protein format |
| CHEMBL2105763 |  |
IC50 | = | 0.4 | nM | 394.48 | Cn1cc(CNCC2CCN(c3ncc(C(=O)NO)cn3)CC2)c2ccccc21 | Homo sapiens | CHEMBL4771400 | cell-based format |
| CHEMBL4130288 |  |
IC50 | = | 1.0 | nM | 391.35 | CC1(C)c2cccc(C(=O)NO)c2CN1c1nc2cc(C(F)(F)F)ccc2o1 | Homo sapiens | CHEMBL4123079 | assay format |
| CHEMBL3356916 |  |
IC50 | = | 1.0 | nM | 391.54 | Cc1cccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@@H]2CCCC(=O)N2)c1 | Homo sapiens | CHEMBL3379484 | single protein format |
| CHEMBL483254 |  |
IC50 | = | 1.6 | nM | 349.43 | Cc1[nH]c2ccccc2c1CCNCc1ccc(/C=C/C(=O)NO)cc1 | Homo sapiens | CHEMBL4339277 | single protein format |
| CHEMBL4127020 |  |
IC50 | = | 2.0 | nM | 390.37 | CC1(C)c2cccc(C(=O)NO)c2CN1c1nc2ccc(C(F)(F)F)cc2[nH]1 | Homo sapiens | CHEMBL4123079 | assay format |
| CHEMBL4127743 |  |
IC50 | = | 2.0 | nM | 362.31 | O=C(NO)c1cccc2c1CN(c1nc3ccc(C(F)(F)F)cc3[nH]1)C2 | Homo sapiens | CHEMBL4123079 | assay format |
| CHEMBL4128972 |  |
IC50 | = | 2.0 | nM | 324.34 | CC1(C)c2cccc(C(=O)NO)c2CN1c1nc2ncccc2o1 | Homo sapiens | CHEMBL4123079 | assay format |
| CHEMBL609583 |  |
IC50 | = | 2.1 | nM | 413.46 | O=C(NO)c1cnc(N2CCN(S(=O)(=O)c3ccc4ccccc4c3)CC2)nc1 | Homo sapiens | CHEMBL1068537 | single protein format |
| CHEMBL3356917 |  |
IC50 | = | 3.0 | nM | 391.54 | Cc1ccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@@H]2CCCC(=O)N2)cc1 | Homo sapiens | CHEMBL3379484 | single protein format |
| CHEMBL4126661 |  |
IC50 | = | 3.0 | nM | 352.32 | CC1(C)c2cccc(C(=O)NO)c2CN1c1cnc(C(F)(F)F)cn1 | Homo sapiens | CHEMBL4123079 | assay format |
| CHEMBL1796689 |  |
IC50 | = | 3.0 | nM | 496.68 | CC(C)[C@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O | Homo sapiens | CHEMBL3366349 | single protein format |
| CHEMBL4127735 |  |
IC50 | = | 3.0 | nM | 351.33 | CC1(C)c2cccc(C(=O)NO)c2CN1c1ccc(C(F)(F)F)nc1 | Homo sapiens | CHEMBL4123079 | assay format |
| CHEMBL3356925 |  |
IC50 | = | 4.0 | nM | 439.58 | O=C1NC[C@@H](c2ccccc2)[C@@H]1C(=O)N[C@@H](CCCCCS)C(=O)Nc1ccccc1 | Homo sapiens | CHEMBL3379484 | single protein format |
| CHEMBL3356526 |  |
IC50 | = | 5.0 | nM | 391.54 | CN1C(=O)CCC[C@H]1C(=O)N[C@@H](CCCCCS)C(=O)Nc1ccccc1 | Homo sapiens | CHEMBL3379484 | single protein format |
| CHEMBL4127894 |  |
IC50 | = | 5.0 | nM | 352.32 | CC1(C)c2cccc(C(=O)NO)c2CN1c1ncc(C(F)(F)F)cn1 | Homo sapiens | CHEMBL4123079 | assay format |
| CHEMBL3356923 |  |
IC50 | = | 5.0 | nM | 377.51 | Cc1cccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@H]2CCC(=O)N2)c1 | Homo sapiens | CHEMBL3379484 | single protein format |
| CHEMBL3622533 |  |
IC50 | = | 5.4 | nM | 508.56 | COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ncc(C(=O)NO)cn4)cc3n2)cn1 | Homo sapiens | CHEMBL3829041 | cell-based format |
| CHEMBL5278968 |  |
IC50 | = | 5.4 | nM | 506.59 | COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ccc(C(=O)NO)cc4)cc3n2)cn1 | Homo sapiens | CHEMBL5225401 | single protein format |