Q96D31 | CRCM1_HUMAN | Calcium release-activated calcium channel protein 1 (ORAI1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07856 | Orai-1 - Mediator of CRAC channel activity | 72~266 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3984105 |  |
IC50 | = | 26.0 | nM | 366.39 | COc1ccc(OC)c(-c2ccc(N(C)C(=O)c3ccncc3F)cc2)c1 | Homo sapiens | CHEMBL3870014 | assay format |
| CHEMBL3699940 |  |
IC50 | = | 39.17 | nM | 426.4 | O=C(Cn1nnc2ccccc21)Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3706248 | cell-based format |
| CHEMBL3699935 |  |
IC50 | = | 51.31 | nM | 398.47 | O=C(Cn1nnc2ccccc21)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3706248 | cell-based format |
| CHEMBL3699939 |  |
IC50 | = | 53.36 | nM | 423.4 | O=C(Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1)c1ccc2nccnc2c1 | Homo sapiens | CHEMBL3706248 | cell-based format |
| CHEMBL3699938 |  |
IC50 | = | 86.12 | nM | 422.41 | O=C(Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1)c1ccc2ncccc2c1 | Homo sapiens | CHEMBL3706248 | cell-based format |
| CHEMBL3403744 |  |
IC50 | < | 100.0 | nM | 394.76 | Cn1nc(C(F)(F)F)cc1-c1cnc2[nH]c(-c3c(F)cccc3Cl)cc2c1 | Homo sapiens | CHEMBL3405048 | cell-based format |
| CHEMBL3403751 |  |
IC50 | = | 104.0 | nM | 367.81 | COc1cc(C)c(-c2cnc3[nH]c(-c4c(F)cccc4Cl)cc3c2)cn1 | Homo sapiens | CHEMBL3405048 | cell-based format |
| CHEMBL3699941 |  |
IC50 | = | 139.0 | nM | 426.4 | O=C(Cn1nc2ccccc2n1)Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3706248 | cell-based format |
| CHEMBL3699936 |  |
IC50 | = | 146.7 | nM | 408.51 | O=C(Cc1ccc2ncccc2c1)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3706248 | cell-based format |
| CHEMBL3699942 |  |
IC50 | = | 160.5 | nM | 444.39 | O=C(Cn1nnc2ccccc21)Nc1ccc(-n2nc(C(F)(F)F)cc2C2CC2)c(F)c1 | Homo sapiens | CHEMBL3706248 | cell-based format |
| CHEMBL3699933 |  |
IC50 | = | 182.5 | nM | 384.44 | O=C(Nc1ccc(-n2nc(C3CC3)cc2C2CC2)cc1)c1ccc2nn[nH]c2c1 | Homo sapiens | CHEMBL3706248 | cell-based format |
| CHEMBL3699937 |  |
IC50 | = | 263.2 | nM | 426.5 | O=C(Cc1ccc2ncccc2c1)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)c(F)c1 | Homo sapiens | CHEMBL3706248 | cell-based format |
| CHEMBL3699934 |  |
IC50 | = | 383.1 | nM | 397.48 | O=C(Cn1cnc2ccccc21)Nc1ccc(-n2nc(C3CC3)cc2C2CC2)cc1 | Homo sapiens | CHEMBL3706248 | cell-based format |
| CHEMBL3403753 |  |
IC50 | = | 440.0 | nM | 383.81 | COc1cc(OC)c(-c2cnc3[nH]c(-c4c(F)cccc4Cl)cc3c2)cn1 | Homo sapiens | CHEMBL3405048 | cell-based format |