Q96C86 | DCPS_HUMAN | m7GpppX diphosphatase (DCPS)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF05652 | DcpS - Scavenger mRNA decapping enzyme (DcpS) N-terminal | 45~146 | |
| PF11969 | DcpS_C - Scavenger mRNA decapping enzyme C-term binding | 174~292 |
3D structures mapped by conservation among orthologs
[ Domain: "mRNA decapping enzyme DcpS N-terminal domain" // DcpS ]
[ Domain: "HIT-related" // DcpS_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL251428 |  |
IC50 | = | 0.02 | nM | 302.28 | Nc1nc(N)c2c(COc3ccc(F)cc3F)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL251906 |  |
IC50 | = | 0.02 | nM | 284.29 | Nc1nc(N)c2c(COc3ccccc3F)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL4465809 |  |
IC50 | < | 0.02 | nM | 348.36 | Nc1nc(N)c2c(OCc3ccc(S(=O)(=O)F)cc3)cccc2n1 | Homo sapiens | CHEMBL4351061 | single protein format |
| CHEMBL4080254 |  |
IC50 | = | 0.03 | nM | 363.47 | Nc1nc(N)c2c(OCC3CCN(Cc4ccccc4)CC3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL4082618 |  |
IC50 | = | 0.04 | nM | 415.9 | Nc1nc(N)c2c(OCC3CCN(Cc4c(F)cccc4Cl)CC3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL255019 |  |
IC50 | = | 0.05 | nM | 300.75 | Nc1nc(N)c2c(COc3cccc(Cl)c3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL4072132 |  |
IC50 | = | 0.069 | nM | 432.36 | Nc1nc(N)c2c(OCC3CCN(Cc4c(Cl)cccc4Cl)CC3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL4077061 |  |
IC50 | = | 0.11 | nM | 309.3 | N#Cc1cc(F)cc(OCc2cccc3nc(N)nc(N)c23)c1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL250072 |  |
IC50 | = | 0.11 | nM | 397.91 | Nc1nc(N)c2c(OCC3CCN(Cc4ccccc4Cl)CC3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL398675 |  |
IC50 | = | 0.19 | nM | 302.28 | Nc1nc(N)c2c(OCc3cc(F)cc(F)c3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL4062544 |  |
IC50 | = | 0.25 | nM | 284.29 | Nc1nc(N)c2c(COc3cccc(F)c3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL4061457 |  |
IC50 | = | 0.27 | nM | 281.32 | Cc1ncccc1OCc1cccc2nc(N)nc(N)c12 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL399673 |  |
IC50 | = | 0.29 | nM | 300.75 | Nc1nc(N)c2c(COc3ccccc3Cl)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL4076514 |  |
IC50 | = | 0.32 | nM | 432.36 | Nc1nc(N)c2c(OCC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL342595 |  |
IC50 | = | 1.01 | nM | 266.3 | Nc1nc(N)c2c(OCc3ccccc3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL4103454 |  |
IC50 | = | 1.39 | nM | 447.46 | Nc1nc(N)c2c(OCC3CCN(Cc4ccccc4OC(F)(F)F)CC3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL4068466 |  |
IC50 | = | 1.77 | nM | 274.32 | Nc1nc(N)c2c(OCC3CCOCC3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL4072481 |  |
IC50 | = | 2.3 | nM | 274.32 | Nc1nc(N)c2c(COC3CCOCC3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL250231 |  |
IC50 | = | 2.89 | nM | 300.75 | Nc1nc(N)c2c(OCc3cccc(Cl)c3)cccc2n1 | Homo sapiens | CHEMBL4010335 | single protein format |
| CHEMBL251429 |  |
IC50 | = | 7.62 | nM | 381.45 | Nc1nc(N)c2c(OCC3CCN(Cc4ccccc4F)CC3)cccc2n1 | Homo sapiens | CHEMBL3992399 | single protein format |