Q969S8 | HDA10_HUMAN | Polyamine deacetylase HDAC10 (HDAC10)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00850 | Hist_deacetyl - Histone deacetylase domain | 25~320 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3593247 |  |
IC50 | = | 0.5 | nM | 496.68 | CC(C)[C@@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O | Homo sapiens | CHEMBL4021388 | cell-based format |
| CHEMBL1796689 |  |
IC50 | = | 0.5 | nM | 496.68 | CC(C)[C@H]1NC(=O)[C@]2(C)CSC(=N2)c2csc(n2)CNC(=O)C[C@@H](/C=C/CCS)OC1=O | Homo sapiens | CHEMBL3366348 | single protein format |
| CHEMBL4532398 |  |
IC50 | = | 0.58 | nM | 566.66 | C[C@@H]1CN(C(=O)Nc2ccc(-c3nc(N4CCOCC4)c4cnn(CCCCCCC(=O)NO)c4n3)cc2)CCO1 | Homo sapiens | CHEMBL4413544 | cell-based format |
| CHEMBL3827517 |  |
IC50 | = | 0.86 | nM | 476.5 | CN(Cc1nc2c(N3CCOCC3)nc(-c3ccncc3)nc2n1C)c1ncc(C(=O)NO)cn1 | Homo sapiens | CHEMBL3829040 | cell-based format |
| CHEMBL343448 |  |
IC50 | = | 0.9 | nM | 540.71 | C/C=C1\NC(=O)[C@H]2CSSCC/C=C/[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O | Homo sapiens | CHEMBL3366359 | single protein format |
| CHEMBL3356916 |  |
IC50 | = | 1.0 | nM | 391.54 | Cc1cccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@@H]2CCCC(=O)N2)c1 | Homo sapiens | CHEMBL3379483 | single protein format |
| CHEMBL3310505 |  |
IC50 | = | 1.0 | nM | 540.71 | C/C=C1\NC(=O)[C@H]2CSSCC/C=C/[C@@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@H](C(C)C)NC1=O | Homo sapiens | CHEMBL4771399 | single protein format |
| CHEMBL4552057 |  |
IC50 | = | 1.43 | nM | 439.52 | Nc1ccc(-c2nc(N3CCOCC3)c3cnn(CCCCCCC(=O)NO)c3n2)cc1 | Homo sapiens | CHEMBL4413544 | cell-based format |
| CHEMBL4785064 |  |
IC50 | = | 1.7 | nM | 440.51 | Nc1ccc(-c2nc(N3CCOCC3)c3ncn(CCCCCCC(=O)NO)c3n2)cn1 | Homo sapiens | CHEMBL4707193 | cell-based format |
| CHEMBL2105763 |  |
IC50 | = | 1.96 | nM | 394.48 | Cn1cc(CNCC2CCN(c3ncc(C(=O)NO)cn3)CC2)c2ccccc21 | Homo sapiens | CHEMBL4376743 | cell-based format |
| CHEMBL4460552 |  |
IC50 | = | 1.98 | nM | 490.61 | C[C@H](NC(=O)c1nc(-c2ncc(-c3ccccc3)s2)sc1C1CC1)c1ccc(C(=O)NO)cc1 | Homo sapiens | CHEMBL4357506 | cell-based format |
| CHEMBL3356924 |  |
IC50 | = | 2.0 | nM | 391.54 | Cc1cccc(NC(=O)[C@H](CCCCCS)NC(=O)[C@H]2CCC(=O)N2C)c1 | Homo sapiens | CHEMBL3379483 | single protein format |
| CHEMBL4464421 |  |
IC50 | = | 2.1 | nM | 420.49 | CCOC(=O)Nc1cccc(-c2csc(NC(=O)CCCCCC(=O)NO)n2)c1 | Homo sapiens | CHEMBL4401313 | single protein format |
| CHEMBL4744689 |  |
IC50 | = | 2.3 | nM | 440.51 | Nc1ncc(-c2nc(N3CCOCC3)c3ccn(CCCCCCC(=O)NO)c3n2)cn1 | Homo sapiens | CHEMBL4707193 | cell-based format |
| CHEMBL4749655 |  |
IC50 | = | 2.5 | nM | 454.53 | O=C(CCCCCCn1cnc2c(N3CCOCC3)nc(-c3cccc(CO)c3)nc21)NO | Homo sapiens | CHEMBL4707193 | cell-based format |
| CHEMBL3827814 |  |
IC50 | = | 2.8 | nM | 490.53 | CN(Cc1nc2c(N3CCOCC3)nc(-c3ccc(N)cc3)nc2n1C)c1ncc(C(=O)NO)cn1 | Homo sapiens | CHEMBL3829040 | cell-based format |
| CHEMBL5278968 |  |
IC50 | = | 2.8 | nM | 506.59 | COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ccc(C(=O)NO)cc4)cc3n2)cn1 | Homo sapiens | CHEMBL5225400 | single protein format |
| CHEMBL3622533 |  |
IC50 | = | 2.8 | nM | 508.56 | COc1ccc(-c2nc(N3CCOCC3)c3sc(CN(C)c4ncc(C(=O)NO)cn4)cc3n2)cn1 | Homo sapiens | CHEMBL3829040 | cell-based format |
| CHEMBL3827894 |  |
IC50 | = | 2.83 | nM | 492.5 | CN(Cc1nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2n1C)c1ncc(C(=O)NO)cn1 | Homo sapiens | CHEMBL3829040 | cell-based format |
| CHEMBL2414098 |  |
IC50 | = | 3.0 | nM | 340.22 | O=C(CCCCCCc1nc2ccc(Br)cc2[nH]1)NO | Homo sapiens | CHEMBL2417247 | single protein format |