Q969F8 | KISSR_HUMAN | KiSS-1 receptor (KISS1R)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 59~323 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3645499 |  |
IC50 | = | 0.12 | nM | 183.29 | CNC/C=C/[C@@H](CC(C)C)C(C)=O | Homo sapiens | CHEMBL3705152 | single protein format |
| CHEMBL3645498 |  |
IC50 | = | 0.71 | nM | 200.28 | CNCC(=O)N[C@@H](CC(C)C)C(C)=O | Homo sapiens | CHEMBL3705152 | single protein format |
| CHEMBL3645500 |  |
IC50 | = | 1.2 | nM | 185.31 | CNCCC[C@@H](CC(C)C)C(C)=O | Homo sapiens | CHEMBL3705152 | single protein format |
| CHEMBL1173643 |  |
IC50 | = | 3.6 | nM | 483.5 | N#Cc1c(-c2cccc(N3CCNCC3)c2)cc(-c2ccc(F)cc2O)nc1NC(=O)c1ccco1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL1163809 |  |
IC50 | = | 3.7 | nM | 485.48 | N#Cc1c(-c2cccc(NC(=O)CCN)c2)cc(-c2ccc(F)cc2O)nc1NC(=O)c1ccco1 | Homo sapiens | CHEMBL1167874 | cell-based format |
| CHEMBL1171484 |  |
IC50 | = | 4.1 | nM | 471.45 | N#Cc1c(-c2cccc(NC(=O)CN)c2)cc(-c2ccc(F)cc2O)nc1NC(=O)c1ccco1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL3645501 |  |
IC50 | = | 4.6 | nM | 183.29 | CNCC/C=C(/CC(C)C)C(C)=O | Homo sapiens | CHEMBL3705152 | single protein format |
| CHEMBL1169901 |  |
IC50 | = | 4.6 | nM | 499.5 | CNCCC(=O)Nc1cccc(-c2cc(-c3ccc(F)cc3O)nc(NC(=O)c3ccco3)c2C#N)c1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL1173644 |  |
IC50 | = | 7.3 | nM | 497.53 | N#Cc1c(-c2cccc(N3CCCNCC3)c2)cc(-c2ccc(F)cc2O)nc1NC(=O)c1ccco1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL1165222 |  |
IC50 | = | 7.4 | nM | 501.54 | N#Cc1c(-c2cccc(NC(=O)CCN)c2)cc(-c2ccc(F)cc2O)nc1NC(=O)c1cccs1 | Homo sapiens | CHEMBL1167874 | cell-based format |
| CHEMBL1170903 |  |
IC50 | = | 7.9 | nM | 525.54 | N#Cc1c(-c2cccc(NC(=O)C[C@@H]3CCCN3)c2)cc(-c2ccc(F)cc2O)nc1NC(=O)c1ccco1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL1163736 |  |
IC50 | = | 8.0 | nM | 485.48 | N#Cc1c(-c2cccc(C(=O)NCCN)c2)cc(-c2ccc(F)cc2O)nc1NC(=O)c1ccco1 | Homo sapiens | CHEMBL1167874 | cell-based format |
| CHEMBL1170896 |  |
IC50 | = | 8.0 | nM | 541.58 | CCNC(CC)CC(=O)Nc1cccc(-c2cc(-c3ccc(F)cc3O)nc(NC(=O)c3ccco3)c2C#N)c1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL1170911 |  |
IC50 | = | 8.4 | nM | 485.48 | CNCC(=O)Nc1cccc(-c2cc(-c3ccc(F)cc3O)nc(NC(=O)c3ccco3)c2C#N)c1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL1170692 |  |
IC50 | = | 9.7 | nM | 541.58 | CC(C)NC(C)CC(=O)Nc1cccc(-c2cc(-c3ccc(F)cc3O)nc(NC(=O)c3ccco3)c2C#N)c1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL1163896 |  |
IC50 | = | 9.8 | nM | 518.0 | N#Cc1c(-c2cccc(NC(=O)CCN)c2)cc(-c2ccc(Cl)cc2O)nc1NC(=O)c1cccs1 | Homo sapiens | CHEMBL1167874 | cell-based format |
| CHEMBL1170685 |  |
IC50 | = | 10.0 | nM | 527.56 | CCNC(C)CC(=O)Nc1cccc(-c2cc(-c3ccc(F)cc3O)nc(NC(=O)c3ccco3)c2C#N)c1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL1170904 |  |
IC50 | = | 10.0 | nM | 525.54 | N#Cc1c(-c2cccc(NC(=O)C[C@H]3CCCN3)c2)cc(-c2ccc(F)cc2O)nc1NC(=O)c1ccco1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL1170468 |  |
IC50 | = | 10.0 | nM | 527.56 | CCN(C)CCC(=O)Nc1cccc(-c2cc(-c3ccc(F)cc3O)nc(NC(=O)c3ccco3)c2C#N)c1 | Homo sapiens | CHEMBL1176639 | cell-based format |
| CHEMBL1169902 |  |
IC50 | = | 10.0 | nM | 513.53 | CN(C)CCC(=O)Nc1cccc(-c2cc(-c3ccc(F)cc3O)nc(NC(=O)c3ccco3)c2C#N)c1 | Homo sapiens | CHEMBL1176639 | cell-based format |