ProtHub

Q93009 | UBP7_HUMAN | Ubiquitin carboxyl-terminal hydrolase 7 (USP7)

Pfam Domain Table

Accession	Domain	Range
PF00443	UCH - Ubiquitin carboxyl-terminal hydrolase	214~518
PF12436	USP7_ICP0_bdg - ICP0-binding domain of Ubiquitin-specific protease 7	620~865
PF14533	USP7_C2 - Ubiquitin-specific protease C-terminal	875~1086
PF22486	MATH_2 - MATH domain	70~194

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL4634092	IC50	=	0.16	nM	482.01	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)C5CC5C4=O)sc23)c1C[C@@H]1CNCCO1	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4635160	IC50	=	0.18	nM	524.09	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)C5C(C4=O)C5(C)C)sc23)c1O[C@@H]1CCNC[C@@H]1C	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4640002	IC50	=	0.18	nM	511.0	O=C([C@H]1Cc2cc(Cl)cc(-c3ccnc4cc(CN5C(=O)CCC5=O)sc34)c2O1)N1CCNCC1	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4649132	IC50	=	0.26	nM	579.04	Cc1cc(Cl)cc(-c2ccnc3cc(Cn4c(=O)ccn(CC(F)(F)F)c4=O)sc23)c1O[C@@H]1CCNC[C@@H]1C	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4638458	IC50	=	0.32	nM	497.06	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)CCC4=O)sc23)c1CN1[C@@H](C)CNC[C@@H]1C	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4643330	IC50	=	0.38	nM	521.0	O=C1CCC(=O)N1Cc1cc2nccc(-c3cc(Cl)cc4c3O[C@@H](c3onc5c3CNCC5)C4)c2s1	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4640729	IC50	=	0.39	nM	496.03	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)C5CC5C4=O)sc23)c1C[C@@H]1CNC[C@@H](C)O1	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4647217	IC50	=	0.44	nM	510.06	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)C5C(C4=O)C5(C)C)sc23)c1C[C@@H]1CNCCO1	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4638998	IC50	=	0.78	nM	509.08	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)C5C(C4=O)C5(C)C)sc23)c1NC1CCCNC1	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4648116	IC50	=	1.1	nM	534.04	Cn1nc2c(c1[C@H]1Cc3cc(Cl)cc(-c4ccnc5cc(CN6C(=O)CCC6=O)sc45)c3O1)CNCC2	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4638573	IC50	=	1.1	nM	496.03	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)C5CC5C4=O)sc23)c1O[C@@H]1CCNC[C@@H]1C	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4641569	IC50	=	1.2	nM	473.96	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)CCC4=O)sc23)c1O[C@@H]1CNC[C@@H]1F	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4643112	IC50	=	1.3	nM	508.09	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)C5C(C4=O)C5(C)C)sc23)c1CC1CCCNC1	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4633860	IC50	=	1.5	nM	473.96	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)CCC4=O)sc23)c1OCC1(F)CNC1	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4648623	IC50	=	1.5	nM	496.03	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)C5CC5C4=O)sc23)c1C[C@H]1OCCN[C@@H]1C	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL5281187	IC50	=	1.5	nM	554.57	NCc1ccc(-c2[nH]nc3c(=O)n(CC4(O)CCN(C(=O)C[C@H](c5ccccc5)C(F)(F)F)CC4)cnc23)cc1	Homo sapiens	CHEMBL5234077	single protein format
CHEMBL4590454	IC50	=	1.5	nM	582.63	Cn1nc2c(=O)n(CC3(O)CCN(C(=O)C[C@H](c4ccccc4)C(F)(F)F)CC3)cnc2c1Cc1ccc(CN)cc1	Homo sapiens	CHEMBL4356422	single protein format
CHEMBL4644317	IC50	=	2.1	nM	484.02	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)CCC4=O)sc23)c1O[C@@H]1CCNC[C@@H]1C	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4642862	IC50	=	2.4	nM	510.06	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)C5C(C4=O)C5(C)C)sc23)c1OC1CCCNC1	Homo sapiens	CHEMBL4605951	single protein format
CHEMBL4640563	IC50	=	3.4	nM	455.97	Cc1cc(Cl)cc(-c2ccnc3cc(CN4C(=O)CCC4=O)sc23)c1O[C@H]1C[C@H](N)C1	Homo sapiens	CHEMBL4605951	single protein format

Pfam Domain Table

[ Domain: "TRAF domain-like" // MATH ]

[ Domain: "Ubiquitin-like" // USP7_C2_C ]

[ Domain: "Ubiquitin-like" // USP7_C2_N ]

[ Domain: "Ubiquitin-like" // USP7_ICP0_bdg_1st ]

[ Domain: "Ubiquitin-like" // USP7_ICP0_bdg_3rd ]

[ Domain: "Ubiquitin-like" // USP7_ICP0_bdg_2nd ]

[ Domain: "Cysteine proteinases" // UCH ]