Q92905 | CSN5_HUMAN | COP9 signalosome complex subunit 5 (COPS5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01398 | JAB - JAB1/Mov34/MPN/PAD-1 ubiquitin protease | 52~163 | |
| PF18323 | CSN5_C - Cop9 signalosome subunit 5 C-terminal domain | 251~329 |
3D structures mapped by conservation among orthologs
[ Domain: "Cytidine deaminase-like" // JAB ]
[ Domain: "26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain" // KOG1554 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4528101 |  |
IC50 | = | 5.8 | nM | 505.57 | CC(C)n1nc(C(F)F)cc1C(=O)Nc1ccc([C@H]2[C@@H](O)CCCc3cncn32)c(-c2ccccc2)c1 | Homo sapiens | CHEMBL4356419 | single protein format |
| CHEMBL4447716 |  |
IC50 | = | 60.0 | nM | 541.66 | Cc1ccc(-c2[nH]c3ncccc3c2CCC(=O)N2CCOC[C@H]2c2nc3ccccc3[nH]2)c(-c2ccccc2)c1 | Homo sapiens | CHEMBL4356419 | single protein format |
| CHEMBL4095913 |  |
IC50 | < | 500.0 | nM | 566.66 | O=C(NCc1ccco1)c1cnc2c(SSc3cccc4cc(C(=O)NCc5ccco5)cnc34)cccc2c1 | Homo sapiens | CHEMBL4049706 | single protein format |