Q92876 | KLK6_HUMAN | Kallikrein-6 (KLK6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00089 | Trypsin - Trypsin | 23~237 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4217078 |  |
IC50 | = | 18.0 | nM | 484.48 | Cc1nn(-c2ccccc2)c(C)c1NC(=O)C(OC(=O)Cc1c(C)[nH]c2ccccc12)C(F)(F)F | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4206734 |  |
IC50 | = | 23.0 | nM | 458.52 | Cc1nn(-c2ccccc2)c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2cc(C(=N)N)ccc12 | Homo sapiens | CHEMBL4201843 | assay format |
| CHEMBL4212718 |  |
IC50 | = | 100.0 | nM | 458.52 | Cc1nn(-c2ccccc2)c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccc(C(=N)N)cc12 | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4216138 |  |
IC50 | = | 100.0 | nM | 417.47 | Cc1nn(-c2ccccc2)c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2cnccc12 | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4210314 |  |
IC50 | = | 130.0 | nM | 440.5 | C#Cc1ccc2c(CC(=O)OCC(=O)Nc3c(C)nn(-c4ccccc4)c3C)c(C)[nH]c2c1 | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4218203 |  |
IC50 | = | 130.0 | nM | 416.48 | Cc1nn(-c2ccccc2)c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccccc12 | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4203947 |  |
IC50 | = | 150.0 | nM | 426.48 | C#Cc1[nH]c2ccccc2c1CC(=O)OCC(=O)Nc1c(C)nn(-c2ccccc2)c1C | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4211164 |  |
IC50 | = | 190.0 | nM | 417.47 | Cc1nn(-c2ccccc2)c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ncccc12 | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4207925 |  |
IC50 | = | 250.0 | nM | 450.93 | Cc1nn(-c2ccccc2)c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccc(Cl)cc12 | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4214705 |  |
IC50 | = | 250.0 | nM | 440.5 | C#Cc1ccc2[nH]c(C)c(CC(=O)OCC(=O)Nc3c(C)nn(-c4ccccc4)c3C)c2c1 | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4218314 |  |
IC50 | = | 290.0 | nM | 401.47 | Cc1[nH]c2ccccc2c1CC(=O)NCC(=O)Nc1cnn(-c2ccccc2)c1C | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4211677 |  |
IC50 | = | 490.0 | nM | 417.47 | Cc1nn(-c2ccccc2)c(C)c1NC(=O)COC(=O)Cc1c(C)[nH]c2ccncc12 | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4212332 |  |
IC50 | = | 640.0 | nM | 416.48 | Cc1nn(-c2ccccc2)c(C)c1NC(=O)COC(=O)Cn1c(C)cc2ccccc21 | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4208878 |  |
IC50 | = | 890.0 | nM | 413.48 | NCc1ccc(NC(=O)c2c([O-])ccc[n+]2Cc2nccn2Cc2ccccc2)cc1 | Homo sapiens | CHEMBL4201827 | assay format |
| CHEMBL4861066 |  |
Ki | = | 800.0 | nM | 328.8 | Cl.NCc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1 | Homo sapiens | CHEMBL4831722 | single protein format |
| CHEMBL4862261 |  |
Ki | = | 1000.0 | nM | 358.83 | COc1ccc2c(O)c(C(=O)Nc3ccc(CN)cc3)ccc2c1.Cl | Homo sapiens | CHEMBL4831723 | single protein format |