Q92831 | KAT2B_HUMAN | Histone acetyltransferase KAT2B (KAT2B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00439 | Bromodomain - Bromodomain | 733~814 | |
| PF00583 | Acetyltransf_1 - Acetyltransferase (GNAT) family | 531~622 | |
| PF06466 | PCAF_N - PCAF (P300/CBP-associated factor) N-terminal domain | 74~326 |
3D structures mapped by conservation among orthologs
[ Domain: "Bromodomain" // Bromodomain ]
[ Domain: "Acyl-CoA N-acyltransferases (Nat)" // Acetyltransf_10 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4543497 |  |
IC50 | = | 10.0 | nM | 429.52 | CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2ccc(Oc3ccccc3)cc2)C1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4103402 |  |
IC50 | = | 13.0 | nM | 312.85 | CC(C)C[C@H]1C[C@@H](Nc2cnn(C)c(=O)c2Cl)CN(C)C1 | Homo sapiens | CHEMBL4003550 | single protein format |
| CHEMBL4449143 |  |
IC50 | = | 14.0 | nM | 443.55 | CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2ccc(OCc3ccccc3)cc2)C1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4439202 |  |
IC50 | = | 17.0 | nM | 421.42 | CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2ccc(OC(F)(F)F)cc2)C1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4216214 |  |
IC50 | = | 19.0 | nM | 337.43 | C[C@H](Nc1nn(C)c(=O)c2cccnc12)[C@H](c1ccccc1)N(C)C | Homo sapiens | CHEMBL4190529 | single protein format |
| CHEMBL4067343 |  |
IC50 | = | 19.0 | nM | 337.43 | C[C@@H](Nc1nn(C)c(=O)c2cccnc12)[C@@H](c1ccccc1)N(C)C | Homo sapiens | CHEMBL4003550 | single protein format |
| CHEMBL4545594 |  |
IC50 | = | 22.0 | nM | 416.32 | CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2cccc(Br)c2)C1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4453637 |  |
IC50 | = | 25.0 | nM | 413.53 | CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2cccc(-c3ccccc3)c2)C1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4570924 |  |
IC50 | = | 30.0 | nM | 353.43 | CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2ccc(O)cc2)C1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4527339 |  |
IC50 | = | 30.0 | nM | 439.87 | CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2ccc(Cl)c(C(F)(F)F)c2)C1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4454700 |  |
IC50 | = | 32.0 | nM | 367.45 | COc1ccc([C@H]2C[C@@H](Nc3nc4cc[nH]c4c(=O)n3C)CN(C)C2)cc1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4454766 |  |
IC50 | = | 35.0 | nM | 393.54 | CCCCc1ccc([C@H]2C[C@@H](Nc3nc4cc[nH]c4c(=O)n3C)CN(C)C2)cc1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4570969 |  |
IC50 | = | 36.0 | nM | 360.47 | Cc1nnc2c3ccccc3c(N[C@@H](C)[C@H](c3ccccc3)N(C)C)nn12 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4471748 |  |
IC50 | = | 41.0 | nM | 337.43 | CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2ccccc2)C1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4457684 |  |
IC50 | = | 47.0 | nM | 387.49 | CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2ccc3ccccc3c2)C1 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4069412 |  |
IC50 | = | 60.0 | nM | 377.29 | CN1C[C@H](Nc2cnn(C)c(=O)c2Br)C[C@H](c2ccccc2)C1 | Homo sapiens | CHEMBL4003557 | cell-based format |
| CHEMBL4088595 |  |
IC50 | = | 70.0 | nM | 457.56 | C[C@H](Nc1nn(C)c(=O)n(C)c1=O)[C@H](c1ccc(S(=O)(=O)c2ccccc2)cc1)N(C)C | Homo sapiens | CHEMBL4003550 | single protein format |
| CHEMBL4565832 |  |
IC50 | = | 73.0 | nM | 301.39 | CN1[C@@H]2CCC[C@H]1C[C@@H](Nc1nc3cc[nH]c3c(=O)n1C)C2 | Homo sapiens | CHEMBL4351620 | assay format |
| CHEMBL4574669 |  |
IC50 | = | 118.0 | nM | 395.46 | CN1C[C@H](Nc2nc3cc[nH]c3c(=O)n2C)C[C@H](c2ccc3c(c2)OCCO3)C1 | Homo sapiens | CHEMBL4351666 | cell-based format |
| CHEMBL4541223 |  |
IC50 | = | 125.0 | nM | 287.37 | Cn1c(N[C@@H]2C[C@H]3CCC[C@@H](C2)N3)nc2cc[nH]c2c1=O | Homo sapiens | CHEMBL4351620 | assay format |