Q92800 | EZH1_HUMAN | Histone-lysine N-methyltransferase EZH1 (EZH1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00856 | SET - SET domain | 624~727 | |
| PF11616 | EZH2_WD-Binding - WD repeat binding protein EZH2 | 39~68 | |
| PF18118 | PRC2_HTH_1 - Polycomb repressive complex 2 tri-helical domain | 159~262 | |
| PF18264 | preSET_CXC - CXC domain | 560~591 | |
| PF21358 | Ezh2_MCSS - Ezh2, MCSS domain | 270~322 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4597193 |  |
IC50 | = | 0.44 | nM | 488.03 | Cc1cc(C)c(CNC(=O)c2cc(Cl)c3c(c2C)O[C@@](C)([C@H]2CC[C@H](N(C)C)CC2)O3)c(=O)[nH]1 | Homo sapiens | CHEMBL5123956 | single protein format |
| CHEMBL5197386 |  |
IC50 | = | 0.47 | nM | 532.48 | Cc1cc(C)c(CNC(=O)c2cc(Br)c3c(c2C)O[C@@](C)([C@H]2CC[C@H](N(C)C)CC2)O3)c(=O)[nH]1 | Homo sapiens | CHEMBL5123956 | single protein format |
| CHEMBL5185991 |  |
IC50 | = | 7.0 | nM | 558.52 | Cc1cc(C)c(CN2CCc3c(Br)c4c(c(C)c3C2=O)OC(C)([C@H]2CC[C@H](N(C)C)CC2)O4)c(=O)[nH]1 | Homo sapiens | CHEMBL5123956 | single protein format |
| CHEMBL3414574 |  |
IC50 | = | 13.0 | nM | 390.49 | CCC(CC)n1ccc2c(C(=O)NCc3c(C)cc(C)[nH]c3=O)cc(C#N)cc21 | Homo sapiens | CHEMBL5123969 | single protein format |
| CHEMBL5187396 |  |
IC50 | = | 21.0 | nM | 532.48 | Cc1cc(C)c(CNC(=O)c2cc(Br)c3c(c2C)OC(C)(C2CCC(N(C)C)CC2)O3)c(=O)[nH]1 | Homo sapiens | CHEMBL5109075 | single protein format |
| CHEMBL5193486 |  |
IC50 | = | 23.0 | nM | 488.03 | Cc1cc(C)c(CNC(=O)c2cc(Cl)c3c(c2C)OC(C)(C2CCC(N(C)C)CC2)O3)c(=O)[nH]1 | Homo sapiens | CHEMBL5109075 | single protein format |
| CHEMBL3360855 |  |
IC50 | = | 45.0 | nM | 539.68 | Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(CN4CCOCC4)cc3)cc3c2cnn3C2CCCC2)c(=O)[nH]1 | Homo sapiens | CHEMBL4735337 | single protein format |
| CHEMBL5196227 |  |
IC50 | = | 45.0 | nM | 571.77 | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1CNN2C(C)C | Homo sapiens | CHEMBL5123956 | single protein format |
| CHEMBL4297463 |  |
IC50 | = | 52.0 | nM | 518.58 | COc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC(F)(F)F)CC2)c2ccccc12 | Homo sapiens | CHEMBL4766109 | single protein format |
| CHEMBL4594174 |  |
IC50 | = | 60.0 | nM | 527.67 | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCNCC3)nc2)cc2c1cnn2C(C)C | Homo sapiens | CHEMBL4479463 | single protein format |
| CHEMBL3414619 |  |
IC50 | = | 69.0 | nM | 569.75 | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C(C)C | Homo sapiens | CHEMBL4479463 | single protein format |
| CHEMBL4567859 |  |
IC50 | = | 86.0 | nM | 595.79 | Cc1cc(C2CCCC2)c(CNC(=O)c2cc(-c3ccc(N4CCN(C(C)C)CC4)nc3)cc3c2cnn3C(C)C)c(=O)[nH]1 | Homo sapiens | CHEMBL4479463 | single protein format |
| CHEMBL4557033 |  |
IC50 | = | 88.0 | nM | 555.73 | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(CC)CC3)nc2)cc2c1cnn2C(C)C | Homo sapiens | CHEMBL4479463 | single protein format |
| CHEMBL4559875 |  |
IC50 | = | 108.0 | nM | 595.79 | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C1CCCC1 | Homo sapiens | CHEMBL4479463 | single protein format |
| CHEMBL5419363 |  |
IC50 | = | 124.0 | nM | 526.69 | CCC(C)n1cc(C)c2c(C(=O)NCc3c(C)cc(C)[nH]c3=O)cc(-c3ccc(N4CCNCC4)nc3)cc21 | Homo sapiens | CHEMBL5319913 | single protein format |
| CHEMBL4545986 |  |
IC50 | = | 126.0 | nM | 597.81 | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C(CC)CC | Homo sapiens | CHEMBL4479463 | single protein format |
| CHEMBL4539055 |  |
IC50 | = | 127.0 | nM | 583.78 | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C(C)(C)C | Homo sapiens | CHEMBL4479463 | single protein format |
| CHEMBL4554286 |  |
IC50 | = | 160.0 | nM | 583.78 | CCCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCN(C(C)C)CC3)nc2)cc2c1cnn2C(C)C | Homo sapiens | CHEMBL4479463 | single protein format |
| CHEMBL4551319 |  |
IC50 | = | 211.0 | nM | 583.78 | Cc1cc(CC(C)C)c(CNC(=O)c2cc(-c3ccc(N4CCN(C(C)C)CC4)nc3)cc3c2cnn3C(C)C)c(=O)[nH]1 | Homo sapiens | CHEMBL4479463 | single protein format |
| CHEMBL2204995 |  |
IC50 | = | 240.0 | nM | 541.7 | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccnc(N3CCN(C)CC3)c2)cc2c1cnn2C(C)C | Homo sapiens | CHEMBL5214634 | single protein format |