Q92794 | KAT6A_HUMAN | Histone acetyltransferase KAT6A (KAT6A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00628 | PHD - PHD-finger | 209~262 | |
| PF00628 | PHD - PHD-finger | 265~310 | |
| PF01853 | MOZ_SAS - MOZ/SAS family | 565~741 | |
| PF17772 | zf-MYST - MYST family zinc finger domain | 506~560 | |
| PF21524 | SAMD1_WH - SAM domain-containing protein 1, WH domain | 11~73 |
3D structures mapped by conservation among orthologs
[ Domain: "HAT1, C-terminal domain" // MOZ_SAS_C ]
[ Domain: "Acyl-CoA N-acyltransferases (Nat)" // MOZ_SAS_N ]
[ Domain: "FYVE/PHD zinc finger" // PHD ]
[ Domain: "FYVE/PHD zinc finger" // PHD_1 ]
[ Domain: "beta-beta-alpha zinc fingers" // PLN00104 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4528993 |  |
IC50 | = | 2.0 | nM | 371.39 | O=C(NNS(=O)(=O)c1ccccc1)c1cc(F)cc(-c2ccccn2)c1 | Homo sapiens | CHEMBL4374936 | cell-based format |
| CHEMBL4468833 |  |
IC50 | = | 5.0 | nM | 401.42 | COc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-c2ccccn2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4437798 |  |
IC50 | = | 5.5 | nM | 394.81 | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(Cl)cc(-c2ccco2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4466823 |  |
IC50 | = | 6.0 | nM | 371.39 | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-c2ccccn2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4456585 |  |
IC50 | = | 6.3 | nM | 389.38 | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-c2ccccn2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4475883 |  |
IC50 | = | 7.0 | nM | 388.42 | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2ccc(C)n2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4539384 |  |
IC50 | = | 8.0 | nM | 385.42 | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-c2ccccn2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4455897 |  |
IC50 | = | 8.0 | nM | 384.43 | Cc1cc(-c2ccccc2)cc(C(=O)NNS(=O)(=O)c2ccccc2)c1F | Homo sapiens | CHEMBL4374936 | cell-based format |
| CHEMBL4521125 |  |
IC50 | = | 9.0 | nM | 379.35 | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-n2nccn2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4441439 |  |
IC50 | = | 9.0 | nM | 386.41 | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-c2ncccn2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4565790 |  |
IC50 | = | 9.4 | nM | 378.36 | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-c2ccco2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4464835 |  |
IC50 | = | 10.0 | nM | 404.85 | O=C(NNS(=O)(=O)c1ccccc1)c1cc(-c2ccccc2)cc(Cl)c1F | Homo sapiens | CHEMBL4374936 | cell-based format |
| CHEMBL4458272 |  |
IC50 | = | 11.0 | nM | 374.39 | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-c2ccco2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4465716 |  |
IC50 | = | 13.0 | nM | 390.4 | COc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2cccn2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4445473 |  |
IC50 | = | 13.0 | nM | 388.42 | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2nccc2C)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4516984 |  |
IC50 | = | 14.0 | nM | 390.37 | O=C(NNS(=O)(=O)c1ccccc1F)c1cc(F)cc(-c2ncccn2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4541948 |  |
IC50 | = | 14.0 | nM | 376.43 | O=C(NNS(=O)(=O)c1ccccc1F)c1cccc(-c2ccsc2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4436877 |  |
IC50 | = | 14.0 | nM | 388.42 | Cc1cc(C(=O)NNS(=O)(=O)c2ccccc2F)cc(-n2cc(C)cn2)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4449163 |  |
IC50 | = | 15.0 | nM | 366.41 | Cc1cc(OC(C)C)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |
| CHEMBL4518462 |  |
IC50 | = | 16.0 | nM | 364.4 | C=CCOc1cc(C)cc(C(=O)NNS(=O)(=O)c2ccccc2F)c1 | Homo sapiens | CHEMBL4404752 | cell-based format |