Q92793 | CBP_HUMAN | CREB-binding protein (CREBBP)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00439 | Bromodomain - Bromodomain | 1104~1178 | |
| PF00569 | ZZ - Zinc finger, ZZ type | 1702~1742 | |
| PF02135 | zf-TAZ - TAZ zinc finger | 354~430 | |
| PF02135 | zf-TAZ - TAZ zinc finger | 1772~1843 | |
| PF02172 | KIX - KIX domain | 588~667 | |
| PF06001 | RING_CBP-p300 - CREB-binding protein/p300, atypical RING domain | 1192~1231 | |
| PF08214 | HAT_KAT11 - Histone acetylation protein | 1342~1647 | |
| PF09030 | Creb_binding - Creb binding | 2014~2113 | |
| PF23570 | PHD_P300 - Histone acetyltransferase p300-like, PHD domain | 1276~1314 |
3D structures mapped by conservation among orthologs
[ Domain: "Elongation factor TFIIS domain 2/ Kix domain of creb binding protein" // KIX ]
[ Domain: "Nuclear receptor coactivator CBP/p300 ibid domain" // Creb_binding ]
[ Domain: "Bromodomain" // Bromodomain ]
- 1JSP
- 2D82
- 2L84
- 2L85
- 2RNY
- 3DWY
- 3P1C
- 3P1D
- 3P1E
- 3P1F
- 3SVH
- 4A9K
- 4N3W
- 4N4F
- 4NR4
- 4NR5
- 4NR6
- 4NR7
- 4NYV
- 4NYW
- 4NYX
- 4OUF
- 4TQN
- 4TS8
- 4WHU
- 4YK0
- 5CGP
- 5DBM
- 5EIC
- 5ENG
- 5EP7
- 5GH9
- 5H85
- 5I83
- 5I86
- 5I89
- 5I8B
- 5I8G
- 5J0D
- 5KTU
- 5KTW
- 5KTX
- 5LPJ
- 5LPL
- 5MME
- 5MMG
- 5MPK
- 5MPN
- 5MPZ
- 5MQE
- 5MQG
- 5MQK
- 5NLK
- 5NRW
- 5NU3
- 5OWK
- 5TB6
- 5W0E
- 5W0F
- 5W0L
- 5W0Q
- 5XXH
- 6ALB
- 6ALC
- 6AXQ
- 6AY3
- 6AY5
- 6DMK
- 6FQO
- 6FQT
- 6FQU
- 6FR0
- 6FRF
[ Domain: "TAZ domain" // zf-TAZ ]
[ Domain: "RING/U-box" // ZZ ]
[ Domain: "RING/U-box" // DUF902 ]
[ Domain: "RING/U-box" // RING_CBP-p300 ]
[ Domain: "FYVE/PHD zinc finger" // PHD_CBP ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4217213 |  |
IC50 | = | 0.9 | nM | 520.58 | CNC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5)c(C(F)F)cc34)nn2C2CCOCC2)C1 | Homo sapiens | CHEMBL4186385 | single protein format |
| CHEMBL5438086 |  |
IC50 | = | 1.0 | nM | 501.51 | COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC(F)(F)CC2)cc1 | Homo sapiens | CHEMBL5317376 | single protein format |
| CHEMBL4088793 |  |
IC50 | = | 1.0 | nM | 551.64 | CC(=O)N1CCC(n2nc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c3c2CCN(C(C)=O)C3)CC1 | Homo sapiens | CHEMBL4058600 | single protein format |
| CHEMBL4069831 |  |
IC50 | = | 1.0 | nM | 511.58 | Cn1cc(-c2cc3c(cc2C(F)F)N(c2nn(C4CCOCC4)c4c2CN(C(N)=O)CC4)CCC3)cn1 | Homo sapiens | CHEMBL4058600 | single protein format |
| CHEMBL4076748 |  |
IC50 | = | 1.1 | nM | 510.59 | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 | Homo sapiens | CHEMBL4058600 | single protein format |
| CHEMBL4061161 |  |
IC50 | = | 1.2 | nM | 558.65 | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCS(=O)(=O)CC2)C1 | Homo sapiens | CHEMBL4058600 | single protein format |
| CHEMBL4203082 |  |
IC50 | = | 1.2 | nM | 456.55 | CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5)ncc34)nn2C2CCOCC2)C1 | Homo sapiens | CHEMBL4186385 | single protein format |
| CHEMBL4208820 |  |
IC50 | = | 1.2 | nM | 510.6 | CNC(=O)c1ccc(-c2cc3cccc(-c4nn(C5CCOCC5)c5c4CN(C(C)=O)CC5)c3cn2)cn1 | Homo sapiens | CHEMBL4186385 | single protein format |
| CHEMBL4060566 |  |
IC50 | = | 1.2 | nM | 587.7 | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCN(S(C)(=O)=O)CC2)C1 | Homo sapiens | CHEMBL4058600 | single protein format |
| CHEMBL4061600 |  |
IC50 | = | 1.4 | nM | 496.56 | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2[C@H]2CCOC2)C1 | Homo sapiens | CHEMBL4058600 | single protein format |
| CHEMBL5204688 |  |
IC50 | = | 1.48 | nM | 461.5 | CC(=O)c1cc(C(=O)Nc2cc(C(C)O)cc(-c3cnn(C4CC4)c3)c2F)c2cc(N)ccn12 | Homo sapiens | CHEMBL5156554 | assay format |
| CHEMBL4080905 |  |
IC50 | = | 1.5 | nM | 509.61 | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCNCC2)C1 | Homo sapiens | CHEMBL4058600 | single protein format |
| CHEMBL4083416 |  |
IC50 | = | 1.5 | nM | 514.55 | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)(F)F)cc43)nn2[C@H]2CCOC2)C1 | Homo sapiens | CHEMBL4058600 | single protein format |
| CHEMBL5191045 |  |
IC50 | = | 1.89 | nM | 421.43 | CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(N)ccn12 | Homo sapiens | CHEMBL5156554 | assay format |
| CHEMBL4098938 |  |
IC50 | = | 2.0 | nM | 523.63 | CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCN(C)CC2)C1 | Homo sapiens | CHEMBL4058600 | single protein format |
| CHEMBL4785363 |  |
IC50 | = | 2.05 | nM | 534.61 | CO[C@H]1CC[C@H](n2c([C@@H]3CCCC(=O)N3c3ccc(F)c(F)c3)nc3cc(-c4c(C)noc4C)ccc32)CC1 | Homo sapiens | CHEMBL5156554 | assay format |
| CHEMBL5179328 |  |
IC50 | = | 2.1 | nM | 435.46 | CNc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(CO)cc(-c4cnn(C)c4)c3F)c2c1 | Homo sapiens | CHEMBL5156554 | assay format |
| CHEMBL4061254 |  |
IC50 | = | 2.2 | nM | 478.55 | CNC(=O)c1c[nH]c2c(C(C)C)nc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc12 | Homo sapiens | CHEMBL4032869 | single protein format |
| CHEMBL4204065 |  |
IC50 | = | 2.4 | nM | 481.56 | CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cn(C)nc5C#N)ncc34)nn2C2CCOCC2)C1 | Homo sapiens | CHEMBL4186385 | single protein format |
| CHEMBL4282264 |  |
IC50 | = | 2.6 | nM | 536.48 | CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O | Homo sapiens | CHEMBL4886505 | single protein format |