Q92753 | RORB_HUMAN | Nuclear receptor ROR-beta (RORB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 270~442 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 20~88 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL38 |  |
IC50 | = | 0.15 | nM | 300.44 | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1 | Homo sapiens | CHEMBL3227241 | single protein format |
| CHEMBL4289691 |  |
IC50 | < | 10.0 | nM | 382.7 | Nc1cc(-c2cc(Cl)cc(Cl)c2)c(C(=O)c2ccccc2Cl)s1 | Homo sapiens | CHEMBL4266821 | assay format |
| CHEMBL4292343 |  |
IC50 | = | 15.0 | nM | 435.77 | CC(C)Oc1cc(Br)cc(-c2ccsc2C(=O)c2ccccc2Cl)c1 | Homo sapiens | CHEMBL4266821 | assay format |
| CHEMBL4289114 |  |
IC50 | = | 26.0 | nM | 446.68 | O=C(c1ccccc1Cl)c1scnc1-c1cc(Br)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL4266821 | assay format |
| CHEMBL4284016 |  |
IC50 | = | 34.0 | nM | 367.78 | O=C(c1ccccc1Cl)c1scnc1-c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL4266821 | assay format |
| CHEMBL4276720 |  |
IC50 | = | 40.0 | nM | 381.81 | Nc1cc(-c2cccc(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 | Homo sapiens | CHEMBL4266821 | assay format |
| CHEMBL4225808 |  |
IC50 | = | 59.0 | nM | 559.5 | CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(-c3ccccc3Cl)c(C(=O)c3ccccc3Cl)s2)cc1 | Homo sapiens | CHEMBL4222296 | assay format |
| CHEMBL4226645 |  |
IC50 | = | 63.0 | nM | 461.69 | Nc1nc(-c2cc(Br)cc(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 | Homo sapiens | CHEMBL4222296 | assay format |
| CHEMBL3105681 |  |
IC50 | = | 64.0 | nM | 559.5 | CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(-c3cccc(Cl)c3)c(C(=O)c3ccccc3Cl)s2)cc1 | Homo sapiens | CHEMBL3385307 | assay format |
| CHEMBL4291888 |  |
IC50 | = | 76.0 | nM | 377.39 | COc1ccccc1C(=O)c1sc(N)cc1-c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL4266821 | assay format |
| CHEMBL4128042 |  |
IC50 | = | 83.0 | nM | 591.7 | C[C@H](NC(=O)c1cc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)cc(C2(C)CC2)c1)C(F)(F)F | Homo sapiens | CHEMBL4121351 | cell-based format |
| CHEMBL4284644 |  |
IC50 | = | 87.0 | nM | 334.23 | O=C(c1ccccc1Cl)c1sccc1-c1ccnc(Cl)c1 | Homo sapiens | CHEMBL4266821 | assay format |
| CHEMBL4293341 |  |
IC50 | = | 90.0 | nM | 375.78 | Nc1ccc(C(=O)c2ccccc2Cl)c(-c2cccc(C(F)(F)F)c2)c1 | Homo sapiens | CHEMBL4266821 | assay format |
| CHEMBL4286904 |  |
IC50 | = | 90.0 | nM | 348.85 | O=C(c1ccccc1Cl)c1sccc1-c1cccc2ccccc12 | Homo sapiens | CHEMBL4266821 | assay format |
| CHEMBL4225823 |  |
IC50 | = | 90.0 | nM | 416.35 | Nc1nc(-c2cccc(C(F)(F)F)c2)c(C(=O)c2ccccc2C(F)(F)F)s1 | Homo sapiens | CHEMBL4222296 | assay format |
| CHEMBL4288028 |  |
IC50 | = | 94.0 | nM | 363.36 | COc1ccccc1C(=O)c1scnc1-c1cccc(C(F)(F)F)c1 | Homo sapiens | CHEMBL4266821 | assay format |
| CHEMBL4226392 |  |
IC50 | = | 110.0 | nM | 427.25 | Nc1nc(-c2cccc(C(F)(F)F)c2)c(C(=O)c2ccccc2Br)s1 | Homo sapiens | CHEMBL4222296 | assay format |
| CHEMBL4126534 |  |
IC50 | = | 115.0 | nM | 551.75 | CC(C)(C)NC(=O)c1cc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)cc(C2(C)CC2)c1 | Homo sapiens | CHEMBL4121351 | cell-based format |
| CHEMBL4127926 |  |
IC50 | = | 119.0 | nM | 593.71 | C[C@H](NC(=O)c1cc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)cc(C(C)(C)C)c1)C(F)(F)F | Homo sapiens | CHEMBL4121351 | cell-based format |
| CHEMBL4227190 |  |
IC50 | = | 120.0 | nM | 417.24 | Nc1nc(-c2ccc(Cl)c(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1 | Homo sapiens | CHEMBL4222296 | assay format |