Q92743 | HTRA1_HUMAN | Serine protease HTRA1 (HTRA1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00219 | IGFBP - Insulin-like growth factor binding protein | 37~89 | |
| PF07648 | Kazal_2 - Kazal-type serine protease inhibitor domain | 110~155 | |
| PF13365 | Trypsin_2 - Trypsin-like peptidase domain | 204~342 | |
| PF17820 | PDZ_6 - PDZ domain | 414~464 |
3D structures mapped by conservation among orthologs
[ Domain: "FMN-binding split barrel 2" // Trypsin_2 ]
[ Domain: "PDZ domain" // PDZ_2 ]
[ Domain: "Kazal-type serine protease inhibitors" // Kazal_1_1 ]
[ Domain: "Growth factor receptor domain" // IGFBP ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5092239 |  |
IC50 | = | 1.6 | nM | 591.96 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)C(F)(F)c2ccc(Cl)cc2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5088663 |  |
IC50 | = | 1.8 | nM | 598.06 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)C(c2ccc(Cl)cc2)C(C)C)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5079892 |  |
IC50 | = | 1.82 | nM | 591.96 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)C(F)(F)c2cccc(Cl)c2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5073212 |  |
IC50 | = | 2.9 | nM | 596.05 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)C2(c3cccc(Cl)c3)CCC2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5076658 |  |
IC50 | = | 3.3 | nM | 597.55 | COC[C@H](NC(=O)C1(C(F)(F)F)CCCC1)C(=O)N[C@H](C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)c1ccc(OC)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5084221 |  |
IC50 | = | 3.4 | nM | 591.51 | COc1ccc([C@H](NC(=O)[C@H](CO)NC(=O)C(F)(F)c2cccc(F)c2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL4520468 |  |
IC50 | = | 4.0 | nM | 597.57 | CC(C)[C@H](NC(=O)[C@@H]1C[C@H](c2ccccc2)CN1C(=O)[C@@H](CC1CCCCC1)NC(=O)c1ccc2ccccc2c1)B(O)O | Homo sapiens | CHEMBL4418436 | single protein format |
| CHEMBL5084310 |  |
IC50 | = | 4.6 | nM | 596.05 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)C(c2ccc(Cl)cc2)C2CC2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5086899 |  |
IC50 | = | 5.9 | nM | 598.06 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)[C@H](c2ccc(Cl)cc2)C(C)C)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5081934 |  |
IC50 | = | 7.6 | nM | 584.04 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)C(C)(C)c2cccc(Cl)c2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5079722 |  |
IC50 | = | 7.7 | nM | 590.0 | CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1cnccn1)c1ccccc1)C(=O)C(F)(F)F | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5077623 |  |
IC50 | = | 7.9 | nM | 593.62 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)C2(c3ccccc3F)CCCC2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5089698 |  |
IC50 | = | 8.0 | nM | 566.96 | COc1ccc([C@H](NC(=O)[C@H](CC#N)NC(=O)c2cccc(Cl)c2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5078243 |  |
IC50 | = | 8.0 | nM | 591.96 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)C(F)(F)c2ccccc2Cl)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL4466195 |  |
IC50 | = | 8.95 | nM | 575.41 | CC(C)[C@H](NC(=O)[C@@H]1C[C@@H](OCc2ccccc2)CN1C(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)F | Homo sapiens | CHEMBL4418458 | cell-based format |
| CHEMBL4446596 |  |
IC50 | = | 10.0 | nM | 595.55 | CC(C)[C@H](NC(=O)C1C=C(c2ccccc2)CN1C(=O)[C@@H](CC1CCCCC1)NC(=O)c1ccc2ccccc2c1)B(O)O | Homo sapiens | CHEMBL4418436 | single protein format |
| CHEMBL5092460 |  |
IC50 | = | 10.0 | nM | 591.51 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)c2cccc(OC(F)(F)F)c2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5089717 |  |
IC50 | = | 10.7 | nM | 575.63 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)C2(c3ccccc3)CCCC2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL5070652 |  |
IC50 | = | 13.0 | nM | 547.98 | COc1ccc([C@H](NC(=O)[C@H](C)NC(=O)c2ccc(Cl)s2)C(=O)N[C@H](C(=O)C(F)(F)F)C(C)C)cc1 | Homo sapiens | CHEMBL5053474 | cell-based format |
| CHEMBL4570179 |  |
IC50 | = | 16.0 | nM | 561.53 | CC(C)[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](CC1CCCCC1)NC(=O)c1ccc2ccccc2c1)B(O)O | Homo sapiens | CHEMBL4418436 | single protein format |