Q92731 | ESR2_HUMAN | Estrogen receptor beta (ESR2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 287~480 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 148~216 | |
| PF12497 | ERbeta_N - Estrogen receptor beta | 12~125 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL213829 |  |
IC50 | = | 0.3 | nM | 326.42 | CCCC[C@@]12CCC(=O)C(CC)=C1c1ccc3[nH]nc(F)c3c1C2 | Homo sapiens | CHEMBL868002 | single protein format |
| CHEMBL385680 |  |
IC50 | = | 0.3 | nM | 338.3 | CC[C@@]12CCC(=O)C(C(F)(F)F)=C1c1ccc3[nH]nc(F)c3c1C2 | Homo sapiens | CHEMBL868002 | single protein format |
| CHEMBL182850 |  |
IC50 | = | 0.35 | nM | 323.12 | Oc1cc(Br)c2oc(-c3ccc(O)c(F)c3)cc2c1 | Homo sapiens | CHEMBL832634 | single protein format |
| CHEMBL433944 |  |
IC50 | = | 0.5 | nM | 335.15 | COc1cc(O)c(Br)c2cc(-c3ccc(O)cc3)oc12 | Homo sapiens | CHEMBL832634 | single protein format |
| CHEMBL363634 |  |
IC50 | = | 0.5 | nM | 279.27 | N#Cc1cc(-c2ccc(O)cc2F)cc2ccc(O)cc12 | Homo sapiens | CHEMBL831137 | assay format |
| CHEMBL4228617 |  |
IC50 | = | 0.55 | nM | 428.46 | O=C(O)/C=C/C=C/c1ccc(C2=C(c3ccc(O)cc3)CCOc3cc(F)ccc32)cc1 | Homo sapiens | CHEMBL4219451 | single protein format |
| CHEMBL437695 |  |
IC50 | = | 0.6 | nM | 427.59 | C[C@@H]1CCN(CCOc2ccc([C@@H]3c4ccc(O)cc4CC[C@@H]3c3ccccc3)cc2)C1 | Homo sapiens | CHEMBL863237 | single protein format |
| CHEMBL1083194 |  |
IC50 | = | 0.64 | nM | 499.52 | O=C1CCC(=O)N1CCOc1ccc([C@H]2Oc3cc(O)ccc3C3=C2c2ccc(O)cc2OCC3)cc1 | Homo sapiens | CHEMBL1114099 | single protein format |
| CHEMBL471626 |  |
IC50 | = | 0.7 | nM | 445.53 | Oc1ccc(C2=C(c3ccc(OCCN4CCCC4)cc3)c3ccc(F)cc3OCC2)cc1 | Homo sapiens | CHEMBL940316 | cell-based format |
| CHEMBL377644 |  |
IC50 | = | 0.8 | nM | 348.37 | CCCC[C@@]12CCC(=O)C(C(F)(F)F)=C1c1ccc3[nH]ncc3c1C2 | Homo sapiens | CHEMBL868002 | single protein format |
| CHEMBL197495 |  |
IC50 | = | 0.9 | nM | 427.59 | C[C@@H](COc1ccc([C@@H]2c3ccc(O)cc3CC[C@@H]2c2ccccc2)cc1)N1CCCC1 | Homo sapiens | CHEMBL863237 | single protein format |
| CHEMBL425439 |  |
IC50 | = | 0.9 | nM | 362.35 | CCCC[C@@]12CCC(=O)C(C(F)(F)F)=C1c1ccc3[nH]ncc3c1C2=O | Homo sapiens | CHEMBL868002 | single protein format |
| CHEMBL4227113 |  |
IC50 | = | 0.94 | nM | 477.54 | O=C(/C=C/c1ccc(C2=C(c3ccc(O)cc3)CCOc3cc(F)ccc32)cc1)Nc1ccccc1 | Homo sapiens | CHEMBL4219451 | single protein format |
| CHEMBL379008 |  |
IC50 | = | 1.0 | nM | 282.38 | CCC[C@@H]1C[C@@H]2C[C@]13Cc1cc(O)ccc1C3=C(C)C2=O | Homo sapiens | CHEMBL869284 | single protein format |
| CHEMBL384268 |  |
IC50 | = | 1.0 | nM | 366.36 | CCCC[C@@]12CCC(=O)C(C(F)(F)F)=C1c1ccc3[nH]nc(F)c3c1C2 | Homo sapiens | CHEMBL868002 | single protein format |
| CHEMBL193146 |  |
IC50 | = | 1.1 | nM | 288.7 | Oc1ccc(-c2cc(F)c3c(Cl)c(O)ccc3c2)cc1 | Homo sapiens | CHEMBL831137 | assay format |
| CHEMBL211887 |  |
IC50 | = | 1.1 | nM | 304.75 | CC[C@@]12CCC(=O)C(Cl)=C1c1ccc3[nH]nc(F)c3c1C2 | Homo sapiens | CHEMBL868002 | single protein format |
| CHEMBL91758 |  |
IC50 | = | 1.1 | nM | 463.6 | Oc1ccc2c(c1)S[C@@H](c1ccccc1O)[C@@H](c1ccc(OCCN3CCCCC3)cc1)O2 | Homo sapiens | CHEMBL682167 | single protein format |
| CHEMBL192901 |  |
IC50 | = | 1.1 | nM | 282.27 | O=Cc1cc(O)cc2ccc(-c3ccc(O)c(F)c3)cc12 | Homo sapiens | CHEMBL831137 | assay format |
| CHEMBL211816 |  |
IC50 | = | 1.1 | nM | 308.43 | CCCC[C@@]12CCC(=O)C(CC)=C1c1ccc3[nH]ncc3c1C2 | Homo sapiens | CHEMBL868002 | single protein format |