Q92633 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPAR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 67~311 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_3 ]
[ Domain: "Cytochromes" // Cytochrom_B562_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3966526 |  |
IC50 | = | 0.3 | nM | 513.57 | COc1ccccc1Oc1ccc(C(=O)N(CCCc2cccc(F)c2)Cc2ccc(C(=O)O)cc2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3943133 |  |
IC50 | = | 0.4 | nM | 501.53 | O=C(O)c1ccc(CN(CCCc2cccc(F)c2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3980736 |  |
IC50 | = | 1.0 | nM | 495.55 | O=C(O)c1ccc(CN(CC2CC2c2ccccc2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3911605 |  |
IC50 | = | 2.0 | nM | 485.51 | COc1ccc(CN(Cc2ccc(C(=O)O)cc2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3936755 |  |
IC50 | = | 2.0 | nM | 495.58 | COc1ccccc1Oc1ccc(C(=O)N(CCCc2ccccc2)Cc2ccc(C(=O)O)cc2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3945517 |  |
IC50 | = | 4.0 | nM | 431.49 | COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3901720 |  |
IC50 | = | 4.0 | nM | 459.42 | COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC(F)(F)F)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3900559 |  |
IC50 | = | 4.0 | nM | 485.51 | COc1cccc(CN(Cc2ccc(C(=O)O)cc2)C(=O)c2ccc(Oc3ccccc3F)cc2)c1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3961765 |  |
IC50 | = | 5.0 | nM | 419.48 | CCCN(Cc1ccc(C(=O)O)cc1)C(=O)c1ccc(Oc2ccccc2OC)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3920849 |  |
IC50 | = | 5.0 | nM | 447.53 | CCCCN(Cc1ccc(C(=O)OC)cc1)C(=O)c1ccc(Oc2ccccc2OC)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3891550 |  |
IC50 | = | 6.0 | nM | 455.49 | O=C(O)c1ccc(CN(Cc2ccccc2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3910049 |  |
IC50 | = | 7.0 | nM | 449.48 | COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)c(F)c1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3980174 |  |
IC50 | = | 7.0 | nM | 449.48 | COc1cccc(F)c1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3955284 |  |
IC50 | = | 7.0 | nM | 499.54 | O=C(O)c1ccc(CN(C[C@@H](O)Cc2ccccc2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3892760 |  |
IC50 | = | 7.0 | nM | 455.46 | COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC(C)(F)F)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3987061 |  |
IC50 | = | 9.0 | nM | 473.45 | COc1ccccc1Oc1ccc(C(=O)N(CCC(F)(F)F)Cc2ccc(C(=O)O)cc2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3942894 |  |
IC50 | = | 11.0 | nM | 451.52 | Cc1ccccc1Oc1ccc(C(=O)N(Cc2ccccc2)Cc2ccc(C(=O)O)cc2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3985179 |  |
IC50 | = | 12.0 | nM | 432.48 | COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC2CC2)nc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL4113366 |  |
IC50 | = | 12.0 | nM | 499.54 | O=C(O)c1ccc(CN(C[C@H](O)Cc2ccccc2)C(=O)c2ccc(Oc3ccccc3F)cc2)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |
| CHEMBL3942192 |  |
IC50 | = | 12.0 | nM | 433.5 | COc1ccccc1Oc1ccc(C(=O)N(Cc2ccc(C(=O)O)cc2)CC(C)C)cc1 | Homo sapiens | CHEMBL3889172 | cell-based format |