Q92630 | DYRK2_HUMAN | Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 222~535 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5289179 |  |
IC50 | = | 0.6 | nM | 471.95 | Cl.O=C(c1ccc(Nc2ncc(F)c(-c3ccc4scnc4c3)n2)nc1)N1CCNCC1 | Homo sapiens | CHEMBL5250948 | assay format |
| CHEMBL5084504 |  |
IC50 | = | 1.0 | nM | 308.39 | Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C1CCCC1 | Homo sapiens | CHEMBL5042808 | single protein format |
| CHEMBL5090676 |  |
IC50 | = | 2.0 | nM | 338.4 | Cc1nc(OCc2cncs2)c2c(-c3ccnc(N)c3)c[nH]c2n1 | Homo sapiens | CHEMBL5034577 | single protein format |
| CHEMBL4784318 |  |
IC50 | = | 2.0 | nM | 427.51 | CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 | Homo sapiens | CHEMBL5105999 | single protein format |
| CHEMBL140 |  |
IC50 | = | 2.5 | nM | 368.39 | COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O | Homo sapiens | CHEMBL5250947 | assay format |
| CHEMBL4460561 |  |
IC50 | = | 3.0 | nM | 280.34 | Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C1CC1 | Homo sapiens | CHEMBL5042808 | single protein format |
| CHEMBL3894571 |  |
IC50 | = | 3.16 | nM | 383.41 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 | Homo sapiens | CHEMBL4719513 | single protein format |
| CHEMBL5077927 |  |
IC50 | = | 4.0 | nM | 304.3 | Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CC(F)F | Homo sapiens | CHEMBL5042808 | single protein format |
| CHEMBL5286478 |  |
IC50 | = | 4.0 | nM | 471.95 | Cl.O=C(c1ccc(Nc2ncc(F)c(-c3ccc4scnc4c3)n2)cn1)N1CCNCC1 | Homo sapiens | CHEMBL5250948 | assay format |
| CHEMBL5089294 |  |
IC50 | = | 5.0 | nM | 312.38 | COCCCn1c(C)nc2ccc(-c3cc(N)nc(N)c3)nc21 | Homo sapiens | CHEMBL5042808 | single protein format |
| CHEMBL5073976 |  |
IC50 | = | 6.0 | nM | 334.38 | Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCc1ccco1 | Homo sapiens | CHEMBL5042808 | single protein format |
| CHEMBL5070553 |  |
IC50 | = | 6.0 | nM | 322.29 | Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CC(F)(F)F | Homo sapiens | CHEMBL5042808 | single protein format |
| CHEMBL5094409 |  |
IC50 | = | 6.0 | nM | 296.38 | Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C(C)(C)C | Homo sapiens | CHEMBL5042808 | single protein format |
| CHEMBL5414801 |  |
IC50 | = | 8.0 | nM | 419.49 | CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCCO5)C(=O)N3)cc2)CC1 | Homo sapiens | CHEMBL5363960 | single protein format |
| CHEMBL5091510 |  |
IC50 | = | 8.0 | nM | 337.41 | Cc1nc(OCc2ccsc2)c2c(-c3ccnc(N)c3)c[nH]c2n1 | Homo sapiens | CHEMBL5034577 | single protein format |
| CHEMBL5195216 |  |
IC50 | = | 8.0 | nM | 417.47 | CN1CCN(c2ccc(NC3=N/C(=C\C4=COc5ccccc5O4)C(=O)N3)cc2)CC1 | Homo sapiens | CHEMBL5127381 | assay format |
| CHEMBL5072926 |  |
IC50 | = | 9.0 | nM | 350.47 | Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCC1CCCCC1 | Homo sapiens | CHEMBL5042808 | single protein format |
| CHEMBL5088511 |  |
IC50 | = | 9.0 | nM | 360.42 | Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCOc1ccccc1 | Homo sapiens | CHEMBL5042808 | single protein format |
| CHEMBL4441878 |  |
IC50 | = | 10.0 | nM | 282.35 | Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C(C)C | Homo sapiens | CHEMBL5251371 | cell-based format |
| CHEMBL5422486 |  |
IC50 | = | 10.0 | nM | 432.47 | O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363960 | single protein format |