Q8WZA2 | RPGF4_HUMAN | Rap guanine nucleotide exchange factor 4 (RAPGEF4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00027 | cNMP_binding - Cyclic nucleotide-binding domain | 63~150 | |
| PF00027 | cNMP_binding - Cyclic nucleotide-binding domain | 378~458 | |
| PF00610 | DEP - Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) | 222~289 | |
| PF00617 | RasGEF - RasGEF domain | 775~952 | |
| PF00618 | RasGEF_N - RasGEF N-terminal motif | 499~605 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2313653 |  |
IC50 | = | 400.0 | nM | 274.38 | Cc1ccc(S(=O)(=O)c2c(C)cc(C)cc2C)cc1 | Homo sapiens | CHEMBL3269756 | single protein format |
| CHEMBL3809313 |  |
IC50 | = | 400.0 | nM | 253.39 | Cc1cc(C)c(Nc2c(C)cc(C)cc2C)c(C)c1 | Homo sapiens | CHEMBL3810792 | single protein format |
| CHEMBL3808997 |  |
IC50 | = | 500.0 | nM | 313.75 | Cc1cc(C)c(Nc2cc(Cl)cc(C(F)(F)F)c2)c(C)c1 | Homo sapiens | CHEMBL3810792 | single protein format |
| CHEMBL3808936 |  |
IC50 | = | 500.0 | nM | 259.78 | Cc1cc(C)c(Nc2cccc(Cl)c2C)c(C)c1 | Homo sapiens | CHEMBL3810792 | single protein format |
| CHEMBL3809121 |  |
IC50 | = | 600.0 | nM | 347.3 | Cc1cc(C)c(Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(C)c1 | Homo sapiens | CHEMBL3810792 | single protein format |
| CHEMBL3260989 |  |
IC50 | = | 600.0 | nM | 432.37 | COCCC[n+]1c(C)csc1Nc1c(C)cc(C)cc1C.[I-] | Homo sapiens | CHEMBL3269756 | single protein format |
| CHEMBL3808792 |  |
IC50 | = | 700.0 | nM | 294.23 | Cc1cc(C)c(Nc2c(C)cc(Cl)cc2Cl)c(C)c1 | Homo sapiens | CHEMBL3810792 | single protein format |
| CHEMBL3808606 |  |
IC50 | = | 1000.0 | nM | 313.75 | Cc1cc(C)c(Nc2ccc(Cl)c(C(F)(F)F)c2)c(C)c1 | Homo sapiens | CHEMBL3810793 | single protein format |
| CHEMBL3808989 |  |
IC50 | = | 1000.0 | nM | 239.36 | Cc1cc(C)c(Nc2cccc(C)c2C)c(C)c1 | Homo sapiens | CHEMBL3810792 | single protein format |