Q8WUI4 | HDAC7_HUMAN | Histone deacetylase 7 (HDAC7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00850 | Hist_deacetyl - Histone deacetylase domain | 541~859 |
3D structures mapped by conservation among orthologs
[ Domain: "Arginase/deacetylase" // Hist_deacetyl ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3692689 |  |
IC50 | = | 1.0 | nM | 418.42 | C[C@H](CN(C)Cc1ccccc1)NC(=O)c1ccc(-c2noc(C(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL5156169 | single protein format |
| CHEMBL484073 |  |
IC50 | = | 3.0 | nM | 327.38 | O=C(/C=C/c1ccc2cccnc2c1)NCCCCCC(=O)NO | Homo sapiens | CHEMBL960370 | single protein format |
| CHEMBL2105763 |  |
IC50 | = | 4.04 | nM | 394.48 | Cn1cc(CNCC2CCN(c3ncc(C(=O)NO)cn3)CC2)c2ccccc21 | Homo sapiens | CHEMBL4376741 | cell-based format |
| CHEMBL490018 |  |
IC50 | = | 4.4 | nM | 316.4 | CC(/C=C/c1ccccc1)=C\C(=O)NCCCCCC(=O)NO | Homo sapiens | CHEMBL960370 | single protein format |
| CHEMBL356066 |  |
IC50 | = | 6.11 | nM | 379.46 | O=C(/C=C/c1ccc(CN(CCO)CCc2c[nH]c3ccccc23)cc1)NO | Homo sapiens | CHEMBL1634306 | single protein format |
| CHEMBL484489 |  |
IC50 | = | 6.3 | nM | 328.77 | O=C(/C=C/c1ccc(Cl)cc1F)NCCCCCC(=O)NO | Homo sapiens | CHEMBL960370 | single protein format |
| CHEMBL483254 |  |
IC50 | = | 8.2 | nM | 349.43 | Cc1[nH]c2ccccc2c1CCNCc1ccc(/C=C/C(=O)NO)cc1 | Homo sapiens | CHEMBL4339273 | single protein format |
| CHEMBL3692671 |  |
IC50 | = | 10.0 | nM | 398.43 | CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(-c2noc(C(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL4689589 | single protein format |
| CHEMBL3110001 |  |
IC50 | = | 10.0 | nM | 305.34 | O=C(NO)[C@@H]1[C@H](c2ccccc2)[C@H]1c1ccc2nccnc2c1 | Homo sapiens | CHEMBL3112172 | single protein format |
| CHEMBL2170177 |  |
IC50 | = | 10.0 | nM | 296.33 | COc1ccc(Cn2ccc3ccc(C(=O)NO)cc32)cc1 | Homo sapiens | CHEMBL4035242 | single protein format |
| CHEMBL4761013 |  |
IC50 | = | 12.0 | nM | 408.44 | O=C(NO)c1ccc(CN2C(=O)c3ccccc3S2(=O)=O)cc1-c1ccccc1 | Homo sapiens | CHEMBL4737686 | single protein format |
| CHEMBL4748500 |  |
IC50 | = | 12.0 | nM | 372.38 | O=C(NO)c1ccc(CN2C(=O)c3ccccc3C2=O)cc1-c1ccccc1 | Homo sapiens | CHEMBL4737686 | single protein format |
| CHEMBL4879105 |  |
IC50 | = | 16.0 | nM | 416.4 | O=C(NC1CCN(Cc2ccccc2)C1)c1ccc(-c2noc(C(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL4813407 | cell-based format |
| CHEMBL4798111 |  |
IC50 | = | 20.0 | nM | 382.39 | C[C@H](CN1CCC[C@@H]1C)NC(=O)c1ccc(-c2noc(C(F)(F)F)n2)cc1 | Homo sapiens | CHEMBL4689589 | single protein format |
| CHEMBL3109980 |  |
IC50 | = | 20.0 | nM | 345.78 | O=C(NO)[C@@H]1[C@H](c2ccccc2)[C@H]1c1cc(Cl)c2c(c1)OCCO2 | Homo sapiens | CHEMBL3112172 | single protein format |
| CHEMBL99 |  |
IC50 | = | 22.0 | nM | 302.37 | CC(/C=C/C(=O)NO)=C\[C@@H](C)C(=O)c1ccc(N(C)C)cc1 | Homo sapiens | CHEMBL960037 | single protein format |
| CHEMBL4437833 |  |
IC50 | = | 23.0 | nM | 337.35 | Cc1ncc(-c2ccc(C(C(=O)NO)c3ccccc3F)cc2)cn1 | Homo sapiens | CHEMBL4310910 | cell-based format |
| CHEMBL4799406 |  |
IC50 | = | 24.0 | nM | 390.37 | O=C(NO)c1ccc(CN2C(=O)c3cccc(F)c3C2=O)cc1-c1ccccc1 | Homo sapiens | CHEMBL4737686 | single protein format |
| CHEMBL4751615 |  |
IC50 | = | 27.0 | nM | 456.42 | CC(C)(CNC(=O)c1cccc(-c2noc(C(F)(F)F)n2)c1)c1coc(-c2ccccc2)n1 | Homo sapiens | CHEMBL4737686 | single protein format |
| CHEMBL1631914 |  |
IC50 | = | 27.8 | nM | 454.52 | COc1cc2cc(c1)COc1ccccc1NC(=O)[C@H](CCCCCC(=O)NO)OC/C=C\2 | Homo sapiens | CHEMBL1634306 | single protein format |