Q8TF76 | HASP_HUMAN | Serine/threonine-protein kinase haspin (HASPIN)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF12330 | Haspin_kinase - Haspin like kinase domain | 413~781 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Haspin_kinase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4791276 |  |
IC50 | = | 1.6 | nM | 271.32 | CCn1c(C(N)=O)cc2c1-c1ccncc1OC2(C)C | Homo sapiens | CHEMBL4742450 | cell-based format |
| CHEMBL5178368 |  |
IC50 | = | 2.0 | nM | 292.35 | CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1 | Homo sapiens | CHEMBL5097328 | single protein format |
| CHEMBL5186093 |  |
IC50 | = | 3.0 | nM | 240.22 | Nc1ccc2cc3cnccc3c([N+](=O)[O-])c2n1 | Homo sapiens | CHEMBL5165904 | assay format |
| CHEMBL4064608 |  |
IC50 | = | 4.0 | nM | 385.51 | c1nc(N[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1 | Homo sapiens | CHEMBL4027017 | cell-based format |
| CHEMBL5188318 |  |
IC50 | = | 12.0 | nM | 242.31 | CSc1ncc2cc3cnccc3c(N)c2n1 | Homo sapiens | CHEMBL5165904 | assay format |
| CHEMBL4278808 |  |
IC50 | = | 12.0 | nM | 333.37 | Oc1ccc(-c2nc3ccc4[nH]ncc4c3c3c2CCCC3)c(F)c1 | Homo sapiens | CHEMBL4263654 | single protein format |
| CHEMBL4642838 |  |
IC50 | = | 14.0 | nM | 278.27 | O=C1/C(=C/c2c[nH]c3ncccc23)Oc2cc(O)ccc21 | Homo sapiens | CHEMBL4620608 | assay format |
| CHEMBL1952329 |  |
IC50 | = | 34.0 | nM | 405.42 | CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 | Homo sapiens | CHEMBL2184774 | single protein format |
| CHEMBL4290247 |  |
IC50 | = | 36.0 | nM | 389.46 | O=C(Cc1ccc(F)cc1)Nc1cncc(-c2cc(-c3cccnc3)cs2)c1 | Homo sapiens | CHEMBL4263648 | assay format |
| CHEMBL5181620 |  |
IC50 | = | 50.0 | nM | 256.22 | COc1ncc2cc3cnccc3c([N+](=O)[O-])c2n1 | Homo sapiens | CHEMBL5165904 | assay format |
| CHEMBL5177344 |  |
IC50 | = | 56.0 | nM | 270.36 | CC(C)Sc1ncc2cc3cnccc3c(N)c2n1 | Homo sapiens | CHEMBL5165904 | assay format |
| CHEMBL5194011 |  |
IC50 | = | 65.0 | nM | 270.36 | CCCSc1ncc2cc3cnccc3c(N)c2n1 | Homo sapiens | CHEMBL5165904 | assay format |
| CHEMBL5186471 |  |
IC50 | = | 69.0 | nM | 284.39 | CCCCSc1ncc2cc3cnccc3c(N)c2n1 | Homo sapiens | CHEMBL5165904 | assay format |
| CHEMBL388978 |  |
IC50 | = | 75.6 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328441 | single protein format |
| CHEMBL4637707 |  |
IC50 | = | 77.0 | nM | 290.32 | O=C1/C(=C/c2c[nH]c3ncccc23)CCc2cc(O)ccc21 | Homo sapiens | CHEMBL4620608 | assay format |
| CHEMBL5196946 |  |
IC50 | = | 91.0 | nM | 286.32 | CCSc1ncc2cc3cnccc3c([N+](=O)[O-])c2n1 | Homo sapiens | CHEMBL5165904 | assay format |
| CHEMBL2012574 |  |
IC50 | = | 100.0 | nM | 337.35 | COc1ccc2c3ccnc(C(F)(F)F)c3n(CCCCN)c2c1 | Homo sapiens | CHEMBL2014113 | assay format |
| CHEMBL5208358 |  |
IC50 | = | 114.0 | nM | 300.34 | CC(C)Sc1ncc2cc3cnccc3c([N+](=O)[O-])c2n1 | Homo sapiens | CHEMBL5165904 | assay format |
| CHEMBL5183366 |  |
IC50 | = | 119.0 | nM | 272.29 | CSc1ncc2cc3cnccc3c([N+](=O)[O-])c2n1 | Homo sapiens | CHEMBL5165904 | assay format |
| CHEMBL5202187 |  |
IC50 | = | 124.0 | nM | 256.33 | CCSc1ncc2cc3cnccc3c(N)c2n1 | Homo sapiens | CHEMBL5165904 | assay format |