Q8TDX5 | ACMSD_HUMAN | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF04909 | Amidohydro_2 - Amidohydrolase | 3~330 |
3D structures mapped by conservation among orthologs
[ Domain: "TIM barrels" // Amidohydro_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4072240 |  |
IC50 | = | 3.0 | nM | 393.46 | N#Cc1c(-c2cccs2)nc(SCc2cccc(-c3nnn[nH]3)c2)[nH]c1=O | Homo sapiens | CHEMBL4028573 | assay format |
| CHEMBL4071212 |  |
IC50 | = | 13.0 | nM | 383.45 | N#Cc1c(-c2cccs2)nc(SCc2cccc(CC(=O)O)c2)[nH]c1=O | Homo sapiens | CHEMBL4028573 | assay format |
| CHEMBL4796997 |  |
IC50 | = | 13.0 | nM | 385.47 | N#CC1=C(c2cccs2)NC(SCc2cccc(CC(=O)O)c2)NC1=O | Homo sapiens | CHEMBL4775523 | single protein format |
| CHEMBL4100715 |  |
IC50 | = | 20.0 | nM | 369.43 | N#Cc1c(-c2cccs2)nc(SCc2cccc(C(=O)O)c2)[nH]c1=O | Homo sapiens | CHEMBL4028573 | assay format |
| CHEMBL4553502 |  |
IC50 | = | 25.0 | nM | 409.45 | N#Cc1c(-c2cccs2)nc(SCc2cccc(-c3noc(=O)[nH]3)c2)[nH]c1=O | Homo sapiens | CHEMBL4418029 | cell-based format |
| CHEMBL4578242 |  |
IC50 | = | 31.0 | nM | 369.43 | N#Cc1c(-c2ccsc2)nc(SCc2cccc(C(=O)O)c2)[nH]c1=O | Homo sapiens | CHEMBL4418029 | cell-based format |
| CHEMBL4067706 |  |
IC50 | = | 45.0 | nM | 363.4 | N#Cc1c(-c2ccccc2)nc(SCc2cccc(C(=O)O)c2)[nH]c1=O | Homo sapiens | CHEMBL4028573 | assay format |
| CHEMBL4437596 |  |
IC50 | = | 49.0 | nM | 370.42 | N#Cc1c(-c2nccs2)nc(SCc2cccc(C(=O)O)c2)[nH]c1=O | Homo sapiens | CHEMBL4418029 | cell-based format |
| CHEMBL4580504 |  |
IC50 | = | 66.0 | nM | 353.36 | N#Cc1c(-c2ccco2)nc(SCc2cccc(C(=O)O)c2)[nH]c1=O | Homo sapiens | CHEMBL4418029 | cell-based format |
| CHEMBL4470922 |  |
IC50 | = | 82.0 | nM | 364.39 | N#Cc1c(-c2ccncc2)nc(SCc2cccc(C(=O)O)c2)[nH]c1=O | Homo sapiens | CHEMBL4418029 | cell-based format |
| CHEMBL4465329 |  |
IC50 | = | 82.0 | nM | 397.84 | N#Cc1c(-c2ccc(Cl)cc2)nc(SCc2ccc(C(=O)O)cc2)[nH]c1=O | Homo sapiens | CHEMBL4418029 | cell-based format |
| CHEMBL4458077 |  |
IC50 | = | 88.0 | nM | 423.31 | O=C(O)c1cccc(CSc2nc(-c3cccs3)c(Br)c(=O)[nH]2)c1 | Homo sapiens | CHEMBL4418029 | cell-based format |
| CHEMBL4066693 |  |
IC50 | = | 89.0 | nM | 369.45 | N#Cc1c(C2CCCCC2)nc(SCc2cccc(C(=O)O)c2)[nH]c1=O | Homo sapiens | CHEMBL4028573 | assay format |
| CHEMBL4097581 |  |
IC50 | = | 99.0 | nM | 417.28 | O=C(O)c1cccc(CSc2nc(-c3ccccc3)c(Br)c(=O)[nH]2)c1 | Homo sapiens | CHEMBL4028573 | assay format |
| CHEMBL4458019 |  |
IC50 | = | 100.0 | nM | 285.33 | COc1cccc(/C=C/c2[nH]c(=S)[nH]c(=O)c2C#N)c1 | Homo sapiens | CHEMBL4420580 | cell-based format |
| CHEMBL4465713 |  |
IC50 | = | 100.0 | nM | 373.39 | COc1cccc(/C=C/c2[nH]c(SC)nc(=O)c2C#N)c1OCC(=O)O | Homo sapiens | CHEMBL4420580 | cell-based format |
| CHEMBL4442862 |  |
IC50 | = | 100.0 | nM | 343.3 | COc1cccc(/C=C/c2[nH]c(=O)[nH]c(=O)c2C#N)c1OCC(=O)O | Homo sapiens | CHEMBL4420580 | cell-based format |
| CHEMBL4466867 |  |
IC50 | = | 100.0 | nM | 329.34 | N#Cc1c(/C=C/c2ccccc2OCC(=O)O)[nH]c(=S)[nH]c1=O | Homo sapiens | CHEMBL4420580 | cell-based format |
| CHEMBL4531966 |  |
IC50 | = | 100.0 | nM | 387.42 | COc1cccc(/C=C/c2[nH]c(=S)[nH]c(=O)c2C#N)c1OC(C)(C)C(=O)O | Homo sapiens | CHEMBL4420580 | cell-based format |
| CHEMBL4530672 |  |
IC50 | = | 100.0 | nM | 349.37 | N#Cc1c(-c2cccc(-c3cccc(C(=O)O)c3)c2)[nH]c(=S)[nH]c1=O | Homo sapiens | CHEMBL4420580 | cell-based format |