Q8TDV5 | GP119_HUMAN | Glucose-dependent insulinotropic receptor (GPR119)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 22~279 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2086684 |  |
IC50 | = | 1.0 | nM | 410.48 | C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccncc2C#N)cn1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2382410 |  |
IC50 | = | 1.0 | nM | 422.49 | CC(C)(C)OC(=O)N1C2CCC1CN(c1ncc(OCc3ccncc3C#N)cn1)C2 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2086690 |  |
IC50 | = | 3.0 | nM | 420.48 | CC(C)c1nc(N2CCN(c3ncc(OCc4ccncc4C#N)cn3)[C@H](C)C2)no1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2382409 |  |
IC50 | = | 3.0 | nM | 474.58 | CC(C)(C)OC(=O)N1C2CCC1CN(c1ncc(OCc3ccc(S(C)(=O)=O)cc3)cn1)C2 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2382417 |  |
IC50 | = | 4.0 | nM | 432.49 | CC(C)c1nc(N2C3CCC2CN(c2ncc(OCc4ccncc4C#N)cn2)C3)no1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2382412 |  |
IC50 | = | 6.0 | nM | 480.42 | C[C@@H]1CN(C(=O)OC2CC(F)(F)C2(F)F)CCN1c1ncc(OCc2ccncc2C#N)cn1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2382415 |  |
IC50 | = | 8.0 | nM | 448.41 | N#Cc1cnccc1COc1cnc(N2CC3CCC(C2)N3C(=O)OCC(F)(F)F)nc1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2382413 |  |
IC50 | = | 9.0 | nM | 492.43 | N#Cc1cnccc1COc1cnc(N2CC3CCC(C2)N3C(=O)OC2CC(F)(F)C2(F)F)nc1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2086680 |  |
IC50 | = | 10.0 | nM | 396.45 | CC(C)(C)OC(=O)N1CCN(c2ncc(OCc3ccncc3C#N)cn2)CC1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2382416 |  |
IC50 | = | 12.0 | nM | 406.45 | CC(C)c1nc(N2CCN(c3ncc(OCc4ccncc4C#N)cn3)CC2)no1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2086660 |  |
IC50 | = | 17.0 | nM | 462.57 | C[C@@H]1CN(C(=O)OC(C)(C)C)CCN1c1ncc(OCc2ccc(S(C)(=O)=O)cc2)cn1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2382414 |  |
IC50 | = | 18.0 | nM | 422.37 | N#Cc1cnccc1COc1cnc(N2CCN(C(=O)OCC(F)(F)F)CC2)nc1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2382411 |  |
IC50 | = | 25.0 | nM | 466.4 | N#Cc1cnccc1COc1cnc(N2CCN(C(=O)OC3CC(F)(F)C3(F)F)CC2)nc1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2086687 |  |
IC50 | = | 31.0 | nM | 436.39 | C[C@@H]1CN(C(=O)OCC(F)(F)F)CCN1c1ncc(OCc2ccncc2C#N)cn1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2382408 |  |
IC50 | = | 92.0 | nM | 474.58 | CC(C)(C)OC(=O)N1CC2CCC(C1)N2c1ncc(OCc2ccc(S(C)(=O)=O)cc2)cn1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2086650 |  |
IC50 | = | 351.0 | nM | 448.55 | CC(C)(C)OC(=O)N1CCN(c2ncc(OCc3ccc(S(C)(=O)=O)cc3)cn2)CC1 | Homo sapiens | CHEMBL2382543 | cell-based format |
| CHEMBL2312159 |  |
Ki | = | 7.0 | nM | 508.56 | Cc1c(Oc2ccc(-n3cnnn3)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC(C)(C)C | Homo sapiens | CHEMBL2320533 | cell-based format |
| CHEMBL2204985 |  |
Ki | = | 9.25 | nM | 431.48 | CCc1cnc(N2CCC(n3ncc(COc4ccc(C#N)cc4F)c3C#N)CC2)nc1 | Homo sapiens | CHEMBL2208916 | single protein format |
| CHEMBL2204984 |  |
Ki | = | 14.9 | nM | 456.51 | CCc1cnc(N2CCC(n3ncc(COc4ccc(-n5cnnn5)cc4)c3C#N)CC2)nc1 | Homo sapiens | CHEMBL2208916 | single protein format |
| CHEMBL2312158 |  |
Ki | = | 15.0 | nM | 506.54 | Cc1c(Oc2ccc(-n3cnnn3)cc2F)ncnc1N1C2CC3CC1CC(C2)N3C(=O)OC1(C)CC1 | Homo sapiens | CHEMBL2320533 | cell-based format |