Q8TDS4 | HCAR2_HUMAN | Hydroxycarboxylic acid receptor 2 (HCAR2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 44~294 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL236162 |  |
IC50 | = | 1.0 | nM | 402.86 | O=C(CCc1cnc(-c2ccc(O)cc2Cl)s1)Nc1ccccc1C(=O)O | Homo sapiens | CHEMBL900196 | single protein format |
| CHEMBL1770352 |  |
IC50 | = | 1.0 | nM | 369.34 | N[C@@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)Nc1ccccc1C(=O)O | Homo sapiens | CHEMBL1772682 | single protein format |
| CHEMBL483337 |  |
IC50 | = | 1.0 | nM | 379.42 | O=C(CCc1cnn2c1ccc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1 | Homo sapiens | CHEMBL971523 | cell-based format |
| CHEMBL483336 |  |
IC50 | = | 1.0 | nM | 414.85 | O=C(CCc1noc2c1ccc1c(Cl)c(O)ccc12)NC1=C(C(=O)O)CCCC1 | Homo sapiens | CHEMBL971523 | cell-based format |
| CHEMBL520299 |  |
IC50 | = | 3.0 | nM | 376.37 | O=C(CCc1noc2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O | Homo sapiens | CHEMBL971523 | cell-based format |
| CHEMBL483139 |  |
IC50 | = | 3.0 | nM | 380.4 | O=C(CCc1noc2c1ccc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1 | Homo sapiens | CHEMBL971523 | cell-based format |
| CHEMBL1083138 |  |
IC50 | = | 3.0 | nM | 451.47 | O=C(CCc1ccc2cc(O)ccc2c1)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1 | Homo sapiens | CHEMBL1119082 | cell-based format |
| CHEMBL1770353 |  |
IC50 | = | 4.0 | nM | 369.34 | N[C@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)Nc1ccccc1C(=O)O | Homo sapiens | CHEMBL1772682 | single protein format |
| CHEMBL483353 |  |
IC50 | = | 4.0 | nM | 378.38 | O=C(CCc1noc2c1CCc1cc(O)ccc1-2)Nc1ccccc1C(=O)O | Homo sapiens | CHEMBL971523 | cell-based format |
| CHEMBL1087302 |  |
IC50 | = | 4.0 | nM | 358.35 | O=C(CCc1nc(-c2ccc(O)cn2)no1)NC1=C(C(=O)O)CCCC1 | Homo sapiens | CHEMBL1119082 | cell-based format |
| CHEMBL235256 |  |
IC50 | = | 4.0 | nM | 395.84 | O=C(CCc1ccc(-c2ccc(O)cc2Cl)cc1)Nc1ccccc1C(=O)O | Homo sapiens | CHEMBL900196 | single protein format |
| CHEMBL1084576 |  |
IC50 | = | 4.0 | nM | 400.44 | CCCC1CCC(NC(=O)CCc2nc(-c3ccc(O)cn3)no2)=C(C(=O)O)C1 | Homo sapiens | CHEMBL1119082 | cell-based format |
| CHEMBL485196 |  |
IC50 | = | 4.0 | nM | 382.42 | O=C(CCc1noc2c1CCc1cc(O)ccc1-2)NC1=C(C(=O)O)CCCC1 | Homo sapiens | CHEMBL971523 | cell-based format |
| CHEMBL237248 |  |
IC50 | = | 4.0 | nM | 354.32 | O=C(CCc1nc(-c2ccc(O)cn2)no1)Nc1ccccc1C(=O)O | Homo sapiens | CHEMBL900196 | single protein format |
| CHEMBL1085616 |  |
IC50 | = | 5.0 | nM | 482.49 | CC(Cc1ccn(-c2ccc(O)cn2)n1)C(=O)NC1=C(C(=O)O)CC(c2cc(F)cc(F)c2)CC1 | Homo sapiens | CHEMBL1120319 | single protein format |
| CHEMBL1770355 |  |
IC50 | = | 5.0 | nM | 373.37 | N[C@@H](Cc1nc(-c2ccc(O)cn2)no1)C(=O)NC1=C(C(=O)O)CCCC1 | Homo sapiens | CHEMBL1772682 | single protein format |
| CHEMBL520513 |  |
IC50 | = | 5.0 | nM | 385.45 | O=C(CCc1cn2c(n1)sc1cc(O)ccc12)NC1=C(C(=O)O)CCCC1 | Homo sapiens | CHEMBL971523 | cell-based format |
| CHEMBL1085156 |  |
IC50 | = | 5.0 | nM | 356.38 | O=C(CCc1ccn(-c2ccc(O)cn2)n1)NC1=C(C(=O)O)CCCC1 | Homo sapiens | CHEMBL1120319 | single protein format |
| CHEMBL483352 |  |
IC50 | = | 5.0 | nM | 375.38 | O=C(CCc1[nH]nc2c1ccc1cc(O)ccc12)Nc1ccccc1C(=O)O | Homo sapiens | CHEMBL971523 | cell-based format |
| CHEMBL1086354 |  |
IC50 | = | 6.0 | nM | 395.5 | CCCCC1CCC(NC(=O)CCc2ccc3cc(O)ccc3c2)=C(C(=O)O)C1 | Homo sapiens | CHEMBL1119082 | cell-based format |