Q8TDC3 | BRSK1_HUMAN | Serine/threonine-protein kinase BRSK1 (BRSK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 34~284 | |
| PF21115 | UBA_BRSK - BRSK1/2 UBA domain | 316~358 | |
| PF21122 | KA1_BRSK - BRSK1/2 KA1 domain | 597~715 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 0.856 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328322 | single protein format |
| CHEMBL3780091 |  |
IC50 | = | 2.0 | nM | 323.4 | N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 | Homo sapiens | CHEMBL3784253 | single protein format |
| CHEMBL5407732 |  |
IC50 | = | 43.0 | nM | 429.95 | C[C@@]1(N2CCC(c3cc4cc(NC(=O)C5CC5)ncc4cc3Cl)CC2)COC[C@@H]1O | Homo sapiens | CHEMBL5374415 | single protein format |
| CHEMBL1231206 |  |
IC50 | = | 187.0 | nM | 374.47 | Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1 | Homo sapiens | CHEMBL5212747 | single protein format |