Q8TD08 | MK15_HUMAN | Mitogen-activated protein kinase 15 (MAPK15)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 15~304 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 7.3 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4145869 | single protein format |
| CHEMBL4075720 |  |
IC50 | < | 10.0 | nM | 448.56 | CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4sccc34)cc2)CC1 | Homo sapiens | CHEMBL4155906 | single protein format |
| CHEMBL4762609 |  |
IC50 | = | 110.0 | nM | 457.49 | O=C(Cc1ccc(F)c(F)c1)N1CCC(Nc2ncc3c(N4CCOCC4)n[nH]c3n2)CC1 | Homo sapiens | CHEMBL4673641 | single protein format |
| CHEMBL4169078 |  |
IC50 | = | 130.0 | nM | 379.35 | N#Cc1cnc(Nc2cc(NC[C@H]3CNCCO3)c(C(F)(F)F)cn2)cn1 | Homo sapiens | CHEMBL5212966 | single protein format |
| CHEMBL1234833 |  |
IC50 | = | 330.0 | nM | 385.47 | CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)[C@H](O)CO)nc12 | Homo sapiens | CHEMBL1806346 | single protein format |
| CHEMBL2430323 |  |
IC50 | = | 400.0 | nM | 266.3 | CC(=O)Nc1cccc(-c2cnc3[nH]nc(C)c3c2)c1 | Homo sapiens | CHEMBL2432948 | single protein format |
| CHEMBL4564337 |  |
IC50 | = | 1000.0 | nM | 358.2 | COc1cc2c(-c3cnc(-c4ccc[nH]4)o3)c[nH]c2cc1Br | Homo sapiens | CHEMBL4338188 | single protein format |