Q8TCW9 | PKR1_HUMAN | Prokineticin receptor 1 (PROKR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 79~338 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3956849 |  |
IC50 | = | 50.0 | nM | 411.96 | COc1cc(Cl)ccc1CC1CCN(S(=O)(=O)c2c(C)nn(C)c2C)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3893095 |  |
IC50 | = | 60.0 | nM | 411.96 | COC(c1ccc(Cl)cc1)C1CCN(S(=O)(=O)c2c(C)nn(C)c2C)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3947348 |  |
IC50 | = | 70.0 | nM | 397.93 | COc1cc(Cl)ccc1CC1CCN(S(=O)(=O)c2c(C)n[nH]c2C)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3986275 |  |
IC50 | = | 80.0 | nM | 397.93 | COC(c1ccc(Cl)cc1)C1CCN(S(=O)(=O)c2c(C)n[nH]c2C)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3898520 |  |
IC50 | = | 140.0 | nM | 429.95 | COc1cc(Cl)ccc1CC1(F)CCN(S(=O)(=O)c2c(C)nn(C)c2C)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3958623 |  |
IC50 | = | 170.0 | nM | 415.92 | COc1cc(Cl)ccc1CC1(F)CCN(S(=O)(=O)c2c(C)n[nH]c2C)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3897887 |  |
IC50 | = | 170.0 | nM | 413.93 | COc1cc(Cl)ccc1OC1CCN(S(=O)(=O)c2c(C)nn(C)c2C)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3972544 |  |
IC50 | = | 200.0 | nM | 399.9 | COc1cc(Cl)ccc1OC1CCN(S(=O)(=O)c2c(C)n[nH]c2C)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3954927 |  |
IC50 | = | 200.0 | nM | 427.95 | COc1cc(Cl)ccc1CC1(O)CCN(S(=O)(=O)c2c(C)nn(C)c2C)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3984251 |  |
IC50 | = | 210.0 | nM | 451.9 | Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Oc2ccc(Cl)cc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3910847 |  |
IC50 | = | 210.0 | nM | 437.87 | Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Oc2ccc(Cl)cc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3975166 |  |
IC50 | = | 220.0 | nM | 399.52 | Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Oc2ccc3ccccc3c2)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3976696 |  |
IC50 | = | 240.0 | nM | 394.88 | Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Oc2ccc(Cl)cc2C#N)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3952785 |  |
IC50 | = | 310.0 | nM | 408.91 | Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Oc2ccc(Cl)cc2C#N)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3972452 |  |
IC50 | = | 320.0 | nM | 446.4 | CCc1nn(C)c(CC)c1S(=O)(=O)N1CCC(Oc2ccc(Cl)cc2Cl)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3949632 |  |
IC50 | = | 340.0 | nM | 417.91 | Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(C(c2ccc(Cl)cc2)C(F)F)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3889563 |  |
IC50 | = | 410.0 | nM | 413.93 | COc1cc(Cl)ccc1CC1(O)CCN(S(=O)(=O)c2c(C)n[nH]c2C)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3982097 |  |
IC50 | = | 410.0 | nM | 385.89 | Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(C(F)c2ccc(Cl)cc2)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3973527 |  |
IC50 | = | 440.0 | nM | 399.92 | Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)c(F)c2)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |
| CHEMBL3944037 |  |
IC50 | = | 440.0 | nM | 385.49 | Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Oc2ccc3ccccc3c2)CC1 | Homo sapiens | CHEMBL3889151 | cell-based format |