Q8TCT8 | SPP2A_HUMAN | Signal peptide peptidase-like 2A (SPPL2A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02225 | PA - PA domain | 70~145 | |
| PF04258 | Peptidase_A22B - Signal peptide peptidase | 210~494 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5204104 |  |
IC50 | = | 0.3 | nM | 495.58 | CC(C)C(=O)Nc1cc(NC(=O)C[C@@H](C)C(=O)N[C@@H]2C(=O)N3CCCN3Cc3ccccc32)n(C)n1 | Homo sapiens | CHEMBL5136430 | cell-based format |
| CHEMBL5203663 |  |
IC50 | = | 0.5 | nM | 566.61 | Cc1nc(NC(=O)C(C)C)sc1C(=O)NC[C@H](C(=O)N[C@@H]1C(=O)N2CCCN2Cc2ccccc21)C(F)(F)F | Homo sapiens | CHEMBL5136430 | cell-based format |
| CHEMBL5182068 |  |
IC50 | = | 0.6 | nM | 535.65 | CC(C)C(=O)Nc1cc(NC(=O)C[C@H](C(=O)N[C@@H]2C(=O)N3CCCN3Cc3ccccc32)C2CCC2)n(C)n1 | Homo sapiens | CHEMBL5136430 | cell-based format |
| CHEMBL5171841 |  |
IC50 | = | 1.0 | nM | 512.64 | Cc1nc(NC(=O)C(C)C)sc1C(=O)NC[C@@H](C)C(=O)N[C@@H]1C(=O)N2CCCN2Cc2ccccc21 | Homo sapiens | CHEMBL5136430 | cell-based format |
| CHEMBL5197736 |  |
IC50 | = | 1.0 | nM | 533.05 | CC(C)C(=O)Nc1nc(Cl)c(NC(=O)C[C@@H](C)C(=O)N[C@@H]2C(=O)N3CCCN3Cc3ccccc32)s1 | Homo sapiens | CHEMBL5136430 | cell-based format |
| CHEMBL5199989 |  |
IC50 | = | 1.0 | nM | 517.54 | C[C@H](CC(=O)Nc1cc(C(=O)NCC(F)F)nn1C)C(=O)N[C@@H]1C(=O)N2CCCN2Cc2ccccc21 | Homo sapiens | CHEMBL5136430 | cell-based format |
| CHEMBL4059711 |  |
IC50 | = | 5.0 | nM | 442.47 | C[C@H](CC(=O)Nc1cc(F)cc(F)c1)C(=O)N[C@@H]1C(=O)N2CCCN2Cc2ccccc21 | Homo sapiens | CHEMBL4048263 | cell-based format |
| CHEMBL4762492 |  |
IC50 | = | 7.0 | nM | 416.59 | CC(C)(C)c1cccc(S(=O)(=O)N(C[C@H](O)[C@@H](N)c2ccccc2)C2CCC2)c1 | Homo sapiens | CHEMBL4667901 | cell-based format |
| CHEMBL4759048 |  |
IC50 | = | 9.0 | nM | 500.58 | CC(C)(C)c1ccc(S(=O)(=O)N(C[C@H](O)[C@@H](N)c2ccc(OC(F)(F)F)cc2)C2CCC2)cc1 | Homo sapiens | CHEMBL4667901 | cell-based format |
| CHEMBL392068 |  |
IC50 | = | 10.0 | nM | 479.48 | C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]1C(=O)N(C)c2ccccc2-c2ccccc21 | Homo sapiens | CHEMBL4048263 | cell-based format |
| CHEMBL4753654 |  |
IC50 | = | 13.0 | nM | 470.68 | CC1(C)CCC(C)(C)c2cc(S(=O)(=O)N(C[C@H](O)[C@@H](N)c3ccccc3)C3CCC3)ccc21 | Homo sapiens | CHEMBL4667901 | cell-based format |
| CHEMBL4792187 |  |
IC50 | = | 15.0 | nM | 471.45 | N[C@@H](c1ccccc1)[C@@H](O)CN(C1CCCCCC1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL4667901 | cell-based format |
| CHEMBL4759943 |  |
IC50 | = | 25.0 | nM | 416.59 | CC(C)(C)c1ccc(S(=O)(=O)N(C[C@H](O)[C@@H](N)c2ccccc2)C2CCC2)cc1 | Homo sapiens | CHEMBL4667901 | cell-based format |
| CHEMBL4077007 |  |
IC50 | = | 35.0 | nM | 420.51 | Cc1ccccc1NC(=O)C[C@@H](C)C(=O)N[C@@H]1C(=O)N2CCCN2Cc2ccccc21 | Homo sapiens | CHEMBL4048263 | cell-based format |
| CHEMBL4076827 |  |
IC50 | = | 44.0 | nM | 439.49 | Cc1ncc(F)cc1NC(=O)C[C@@H](C)C(=O)N[C@@H]1C(=O)N2CCCN2Cc2ccccc21 | Homo sapiens | CHEMBL4048263 | cell-based format |
| CHEMBL4064631 |  |
IC50 | = | 70.0 | nM | 420.51 | Cc1cccc(NC(=O)C[C@@H](C)C(=O)N[C@@H]2C(=O)N3CCCN3Cc3ccccc32)c1 | Homo sapiens | CHEMBL4048263 | cell-based format |
| CHEMBL4100749 |  |
IC50 | = | 76.0 | nM | 457.48 | Cc1ncc(F)cc1NC(=O)C[C@@H](C)C(=O)N[C@@H]1C(=O)N2CCCN2Cc2c(F)cccc21 | Homo sapiens | CHEMBL4048263 | cell-based format |
| CHEMBL4069936 |  |
IC50 | = | 77.0 | nM | 505.55 | Cc1ncc(F)cc1NC(=O)C[C@H](C(=O)N[C@@H]1C(=O)N2CC3(CC3)CN2C(=O)c2ccccc21)C1CC1 | Homo sapiens | CHEMBL4048263 | cell-based format |
| CHEMBL4740837 |  |
IC50 | = | 88.0 | nM | 429.37 | N[C@@H](c1ccccc1)[C@@H](O)CN(C1CCC1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL4667901 | cell-based format |
| CHEMBL4762370 |  |
IC50 | = | 200.0 | nM | 431.39 | CC(C)CN(C[C@H](O)[C@@H](N)c1ccccc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL4667901 | cell-based format |