Q8TCT7 | SPP2B_HUMAN | Signal peptide peptidase-like 2B (SPPL2B)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02225 | PA | 74–150 | |
| PF04258 | Peptidase_A22B | 213–502 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4759048 |  |
IC50 | = | 270.0 | nM | 500.58 | CC(C)(C)c1ccc(S(=O)(=O)N(C[C@H](O)[C@@H](N)c2ccc(OC(F)(F)F)cc2)C2CCC2)cc1 | Homo sapiens | CHEMBL4667910 | cell-based format |
| CHEMBL4069936 |  |
IC50 | = | 430.0 | nM | 505.55 | Cc1ncc(F)cc1NC(=O)C[C@H](C(=O)N[C@@H]1C(=O)N2CC3(CC3)CN2C(=O)c2ccccc21)C1CC1 | Homo sapiens | CHEMBL4048267 | cell-based format |