Q8NI77 | KI18A_HUMAN | Kinesin-like protein KIF18A (KIF18A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00225 | Kinesin - Kinesin motor domain | 17~355 |
3D structures mapped by conservation among orthologs
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Kinesin ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4755023 |  |
IC50 | = | 12.0 | nM | 542.58 | O=C(Nc1cccc(OCCC(F)(F)F)n1)c1ccc(S(=O)(=O)NCCO)cc1N1CCC2(CC1)CC2 | Homo sapiens | CHEMBL4731348 | assay format |
| CHEMBL4776977 |  |
IC50 | = | 12.0 | nM | 548.66 | O=C(Nc1cccc(N2CCC(F)(F)CC2)c1)c1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2 | Homo sapiens | CHEMBL4714848 | assay format |
| CHEMBL4784192 |  |
IC50 | = | 12.0 | nM | 529.66 | Cc1ccc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc1N1CCOCC1 | Homo sapiens | CHEMBL4731348 | assay format |
| CHEMBL5070813 |  |
IC50 | = | 13.0 | nM | 565.65 | Cc1cc(NC(=O)c2cnc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc(N2CCC(F)(F)CC2)n1 | Homo sapiens | CHEMBL5053344 | assay format |
| CHEMBL4752657 |  |
IC50 | = | 14.0 | nM | 556.61 | C[C@@H](CO)S(=O)(=O)Nc1ccc(C(=O)Nc2cccc(OCCC(F)(F)F)n2)c(N2CCC3(CC2)CC3)c1 | Homo sapiens | CHEMBL4731348 | assay format |
| CHEMBL4777623 |  |
IC50 | = | 14.0 | nM | 505.59 | Cc1cc(NC(=O)c2ccc(NS(C)(=O)=O)cc2N2CCC3(CC2)CC3)nc(N2CC(F)(F)C2)c1 | Homo sapiens | CHEMBL4731348 | assay format |
| CHEMBL5075318 |  |
IC50 | = | 15.0 | nM | 565.65 | Cc1cc(NC(=O)c2ncc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc(N2CCC(F)(F)CC2)n1 | Homo sapiens | CHEMBL5053344 | assay format |
| CHEMBL5081181 |  |
IC50 | = | 16.0 | nM | 549.64 | O=C(Nc1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2)c1cccc(N2CCC(F)(F)CC2)n1 | Homo sapiens | CHEMBL5051143 | assay format |
| CHEMBL5091710 |  |
IC50 | = | 16.0 | nM | 522.59 | N=[S@@](=O)(c1ccc(C(=O)Nc2cccc(OCCC(F)(F)F)n2)c(N2CCC3(CC2)CC3)c1)C1CC1 | Homo sapiens | CHEMBL5051594 | assay format |
| CHEMBL5094304 |  |
IC50 | = | 16.0 | nM | 550.63 | O=C(Nc1cncc(N2CCC(F)(F)CC2)n1)c1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2 | Homo sapiens | CHEMBL5051594 | assay format |
| CHEMBL4777759 |  |
IC50 | = | 16.0 | nM | 529.66 | C[C@@H]1CN(c2cccc(NC(=O)c3ccc(S(=O)(=O)NCCO)cc3N3CCC4(CC3)CC4)n2)CCO1 | Homo sapiens | CHEMBL4731348 | assay format |
| CHEMBL4746340 |  |
IC50 | = | 16.0 | nM | 556.61 | C[C@H](CO)S(=O)(=O)Nc1ccc(C(=O)Nc2cccc(OCCC(F)(F)F)n2)c(N2CCC3(CC2)CC3)c1 | Homo sapiens | CHEMBL4731348 | assay format |
| CHEMBL5087614 |  |
IC50 | = | 17.0 | nM | 529.66 | Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc(N2CCOCC2)c1 | Homo sapiens | CHEMBL5051594 | assay format |
| CHEMBL5075165 |  |
IC50 | = | 17.0 | nM | 549.64 | Cc1cc(NC(=O)c2ccc(NS(=O)(=O)[C@H](C)CO)cc2N2CCC3(CC2)CC3)nc(N2CC(F)(F)C2)c1 | Homo sapiens | CHEMBL5051594 | assay format |
| CHEMBL4779888 |  |
IC50 | = | 17.0 | nM | 563.67 | Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc(C2CCC(F)(F)CC2)n1 | Homo sapiens | CHEMBL4731848 | assay format |
| CHEMBL4750775 |  |
IC50 | = | 17.0 | nM | 549.64 | O=C(Nc1ccnc(N2CCC(F)(F)CC2)c1)c1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC1)CC2 | Homo sapiens | CHEMBL4731848 | assay format |
| CHEMBL4751673 |  |
IC50 | = | 17.4 | nM | 544.68 | C[C@@H]1CN(c2nccc(NC(=O)c3ccc(NS(=O)(=O)[C@@H](C)CO)cc3N3CCC4(CC3)CC4)n2)CCO1 | Homo sapiens | CHEMBL4731848 | assay format |
| CHEMBL4776120 |  |
IC50 | = | 17.6 | nM | 540.69 | Cc1cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC2)CC3)nc(N2CCC3(CC3)C2)n1 | Homo sapiens | CHEMBL4731848 | assay format |
| CHEMBL5072943 |  |
IC50 | = | 18.0 | nM | 543.69 | Cc1cc(NC(=O)c2ccc(NS(=O)(=O)[C@@H](C)CO)cc2N2CCC3(CC2)CC3)nc(N2CCOCC2)c1 | Homo sapiens | CHEMBL5051594 | assay format |
| CHEMBL5092103 |  |
IC50 | = | 18.0 | nM | 543.69 | Cc1cc(NC(=O)c2ccc(NS(=O)(=O)[C@H](C)CO)cc2N2CCC3(CC2)CC3)nc(N2CCOCC2)c1 | Homo sapiens | CHEMBL5051594 | assay format |