Q8NHM5 | KDM2B_HUMAN | Lysine-specific demethylase 2B (KDM2B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02008 | zf-CXXC - CXXC zinc finger domain | 607~651 | |
| PF12937 | F-box-like - F-box-like | 1068~1107 | |
| PF13621 | Cupin_8 - Cupin-like domain | 141~317 | |
| PF16866 | PHD_4 - PHD-finger | 656~722 | |
| PF17811 | JHD - Jumonji helical domain | 334~373 |
3D structures mapped by conservation among orthologs
[ Domain: "Leucine-rich repeats" // LRR_8_3 ]
[ Domain: "F-box domain" // F-box-like_1 ]
[ Domain: "CXXC domain" // zf-CXXC ]
[ Domain: "FYVE/PHD zinc finger" // PHD_5 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4284112 |  |
IC50 | <= | 100.0 | nM | 303.32 | C#Cc1ccc(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)cc1 | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4283531 |  |
IC50 | <= | 100.0 | nM | 389.81 | COCCCn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(Cl)c(F)c1 | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4288587 |  |
IC50 | <= | 100.0 | nM | 359.79 | CCCn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(Cl)c(F)c1 | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4290844 |  |
IC50 | <= | 100.0 | nM | 348.19 | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(Cl)cc1Cl | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4279368 |  |
IC50 | <= | 100.0 | nM | 343.77 | COc1cc(-c2c(-c3cc(C(=O)O)ccn3)ncn2C)ccc1Cl | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4285705 |  |
IC50 | <= | 100.0 | nM | 331.73 | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(Cl)c(F)c1 | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4294329 |  |
IC50 | <= | 100.0 | nM | 381.74 | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(Cl)cc1C(F)(F)F | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4293976 |  |
IC50 | <= | 100.0 | nM | 297.29 | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1cccc(F)c1 | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4284008 |  |
IC50 | <= | 100.0 | nM | 297.29 | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(F)cc1 | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4285037 |  |
IC50 | <= | 100.0 | nM | 318.34 | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc2cc[nH]c2c1 | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4284538 |  |
IC50 | <= | 100.0 | nM | 375.79 | COCCn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(Cl)c(F)c1 | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4280936 |  |
IC50 | <= | 100.0 | nM | 313.74 | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1cccc(Cl)c1 | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4279120 |  |
IC50 | <= | 100.0 | nM | 313.74 | Cn1cnc(-c2cc(C(=O)O)ccn2)c1-c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4257285 | cell-based format |
| CHEMBL4282684 |  |
IC50 | <= | 100.0 | nM | 426.4 | FC(F)(F)c1[nH]nnc1-c1ccnc(-c2cn(CC3CCOc4ccccc43)cn2)c1 | Homo sapiens | CHEMBL4256998 | cell-based format |
| CHEMBL4282314 |  |
IC50 | <= | 100.0 | nM | 388.33 | Cn1cnc(-c2cc(-c3nn[nH]c3C(F)(F)F)ccn2)c1-c1ccc(F)cc1 | Homo sapiens | CHEMBL4256998 | cell-based format |
| CHEMBL4278582 |  |
IC50 | <= | 100.0 | nM | 414.39 | COc1ccc(CCn2cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c2)cc1 | Homo sapiens | CHEMBL4256998 | cell-based format |
| CHEMBL4279611 |  |
IC50 | <= | 100.0 | nM | 418.81 | FC(F)(F)c1[nH]nnc1-c1ccnc(-c2cn(CCc3ccc(Cl)cc3)cn2)c1 | Homo sapiens | CHEMBL4256998 | cell-based format |
| CHEMBL4293048 |  |
IC50 | <= | 100.0 | nM | 398.39 | Cc1ccc(CCn2cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c2)cc1 | Homo sapiens | CHEMBL4256998 | cell-based format |
| CHEMBL4294086 |  |
IC50 | <= | 100.0 | nM | 467.46 | O=C(c1ccccc1)N1CCC[C@H](n2cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c2)C1 | Homo sapiens | CHEMBL4256998 | cell-based format |
| CHEMBL4284954 |  |
IC50 | <= | 100.0 | nM | 467.46 | O=C(c1ccccc1)N1CCC[C@@H](n2cnc(-c3cc(-c4nn[nH]c4C(F)(F)F)ccn3)c2)C1 | Homo sapiens | CHEMBL4256998 | cell-based format |