Q8NET8 | TRPV3_HUMAN | Transient receptor potential cation channel subfamily V member 3 (TRPV3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00023 | Ank - Ankyrin repeat | 262~293 | |
| PF00023 | Ank - Ankyrin repeat | 340~362 | |
| PF00520 | Ion_trans - Ion transport protein | 442~688 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 125~243 |
3D structures mapped by conservation among orthologs
[ Domain: "Ankyrin repeat" // Ank_2 ]
[ Domain: "Voltage-gated ion channels" // Ion_trans ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3696391 |  |
IC50 | = | 80.0 | nM | 360.39 | CC(C)[C@H](CO)NCc1nc(C2=CCC(C(F)(F)F)CC2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696410 |  |
IC50 | = | 80.0 | nM | 324.35 | CC(C)[C@H](CO)NCc1nc(-c2cc(F)cc(F)c2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3692308 |  |
IC50 | = | 110.0 | nM | 361.44 | CC(C)[C@H](CO)NCc1nc(N2CCc3c(F)cccc3C2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696452 |  |
IC50 | = | 120.0 | nM | 340.8 | CC(C)[C@H](CO)NCc1nc(-c2ccc(F)c(Cl)c2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696433 |  |
IC50 | = | 120.0 | nM | 427.52 | CC(C)[C@H](CO)NCc1nc(-c2cc3ccccc3n2C(=O)OC(C)(C)C)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3692305 |  |
IC50 | = | 120.0 | nM | 347.41 | CC(C)[C@H](CO)NCc1nc(N2Cc3cccc(F)c3C2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696448 |  |
IC50 | = | 130.0 | nM | 312.39 | CC(C)[C@H](CO)NCc1nc(C#Cc2ccccc2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696392 |  |
IC50 | = | 140.0 | nM | 328.38 | CC(C)[C@H](CO)NCc1nc(C2=CCC(F)(F)CC2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696396 |  |
IC50 | = | 140.0 | nM | 324.35 | CC(C)[C@H](CO)NCc1nc(-c2ccc(F)c(F)c2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3692310 |  |
IC50 | = | 140.0 | nM | 361.44 | CC(C)[C@H](CO)NCc1nc(N2CCc3cccc(F)c3C2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3692284 |  |
IC50 | = | 140.0 | nM | 357.35 | CC(C)[C@H](CO)NCc1nc(-c2ccc(C(F)(F)F)cn2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3828278 |  |
IC50 | = | 160.0 | nM | 308.21 | O[C@H](c1ccccn1)C1(c2ccc(Cl)c(Cl)c2)CCC1 | Homo sapiens | CHEMBL3829796 | cell-based format |
| CHEMBL3696409 |  |
IC50 | = | 160.0 | nM | 342.34 | CC(C)[C@H](CO)NCc1nc(-c2cc(F)c(F)cc2F)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696458 |  |
IC50 | = | 160.0 | nM | 329.42 | CC(CCO)CNCc1nc(N2Cc3ccccc3C2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696408 |  |
IC50 | = | 160.0 | nM | 342.34 | CC(C)[C@H](CO)NCc1nc(-c2ccc(F)c(F)c2F)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696407 |  |
IC50 | = | 160.0 | nM | 342.34 | CC(C)[C@H](CO)NCc1nc(-c2cc(F)c(F)c(F)c2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696447 |  |
IC50 | = | 170.0 | nM | 346.49 | CC(C)[C@H](CO)NCc1nc(C#CCCC2CCCCC2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696426 |  |
IC50 | = | 170.0 | nM | 312.39 | CC(C)[C@H](CO)NCc1cccc(C#Cc2ccc(F)cc2)n1 | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3696474 |  |
IC50 | = | 170.0 | nM | 362.39 | CC(C)[C@@H](CO)NCc1nc(-c2ccc(C(F)(F)F)s2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |
| CHEMBL3692282 |  |
IC50 | = | 180.0 | nM | 343.45 | CC(C)[C@H](CO)NCc1nc(N2CCc3ccccc3C2)ccc1F | Homo sapiens | CHEMBL3705773 | cell-based format |