Q8NER1 | TRPV1_HUMAN | Transient receptor potential cation channel subfamily V member 1 (TRPV1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00023 | Ank - Ankyrin repeat | 249~282 | |
| PF00520 | Ion_trans - Ion transport protein | 435~694 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 121~230 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL228451 |  |
IC50 | = | 0.11 | nM | 405.59 | CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)cc2)cc1 | Homo sapiens | CHEMBL5386889 | single protein format |
| CHEMBL4781687 |  |
IC50 | = | 0.27 | nM | 459.47 | CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)Nc2cccc3[nH]c(=O)ccc23)CC1 | Homo sapiens | CHEMBL4775810 | cell-based format |
| CHEMBL5406113 |  |
IC50 | = | 0.46 | nM | 505.54 | CCCN(CCC)c1nc(C(F)(F)F)ccc1CNC(=O)Nc1cccc2c1ccc(=O)n2CCO | Homo sapiens | CHEMBL5337356 | cell-based format |
| CHEMBL3910069 |  |
IC50 | = | 0.5 | nM | 451.96 | Cc1nnc(-c2cnc(C3=CCN(C(=O)Nc4ccc(C(C)(C)C)cc4)CC3)c(Cl)c2)o1 | Homo sapiens | CHEMBL3887100 | assay format |
| CHEMBL3393837 |  |
IC50 | = | 0.55 | nM | 443.47 | CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)Nc2cccc3cnccc23)CC1 | Homo sapiens | CHEMBL3396783 | single protein format |
| CHEMBL4787931 |  |
IC50 | = | 0.64 | nM | 441.41 | Cc1cccc(-n2nc(C(F)(F)F)cc2CNC(=O)Nc2cccc3[nH]c(=O)ccc23)c1 | Homo sapiens | CHEMBL4775810 | cell-based format |
| CHEMBL4789232 |  |
IC50 | = | 0.75 | nM | 445.45 | O=C(NCc1ccc(C(F)(F)F)nc1N1CCCCC1)Nc1cccc2[nH]c(=O)ccc12 | Homo sapiens | CHEMBL4775810 | cell-based format |
| CHEMBL2177429 |  |
IC50 | = | 0.8 | nM | 516.56 | CC1CCN(c2nc(C(F)(F)F)ccc2CNC(=O)[C@@H](C)c2ccc(NS(C)(=O)=O)c(F)c2)CC1 | Homo sapiens | CHEMBL2446587 | cell-based format |
| CHEMBL5426914 |  |
IC50 | = | 0.81 | nM | 490.48 | O=C(NCc1ccc(C(F)(F)F)nc1OCC1CCC1)Nc1cccc2c1ccc(=O)n2CCO | Homo sapiens | CHEMBL5337356 | cell-based format |
| CHEMBL4783757 |  |
IC50 | = | 0.88 | nM | 469.47 | CC(C)c1cccc(-n2nc(C(F)(F)F)cc2CNC(=O)Nc2cccc3[nH]c(=O)ccc23)c1 | Homo sapiens | CHEMBL4775810 | cell-based format |
| CHEMBL229430 |  |
IC50 | = | 0.9 | nM | 430.41 | CC(=O)Nc1nc2c(Oc3cc(-c4ccc(C(F)(F)F)cc4)ncn3)cccc2s1 | Homo sapiens | CHEMBL1113609 | single protein format |
| CHEMBL4784134 |  |
IC50 | = | 0.94 | nM | 431.42 | O=C(NCc1ccc(C(F)(F)F)nc1N1CCCC1)Nc1cccc2[nH]c(=O)ccc12 | Homo sapiens | CHEMBL4775810 | cell-based format |
| CHEMBL3671846 |  |
IC50 | = | 1.0 | nM | 495.96 | COC1CN(c2ncc(C[C@@H](O)CO)cc2Cl)CCN1C(=O)Nc1nc2ccc(F)cc2s1 | Homo sapiens | CHEMBL3706071 | assay format |
| CHEMBL3682255 |  |
IC50 | = | 1.0 | nM | 434.42 | CN1C(=O)NCc2c(NC(=O)N[C@@H]3C[C@](C)(C(F)(F)F)Oc4ccccc43)cccc21 | Homo sapiens | CHEMBL3705924 | cell-based format |
| CHEMBL2312050 |  |
IC50 | = | 1.0 | nM | 363.46 | CC(C)(C)c1ccc(NC(=O)N2CCc3c([nH]c4ccc(O)cc34)C2)cc1 | Homo sapiens | CHEMBL2319705 | cell-based format |
| CHEMBL3935231 |  |
IC50 | = | 1.0 | nM | 473.46 | Cc1cc(NC(=O)N2CC=C(c3ncc(-c4nnc(CO)o4)cc3C)CC2)ccc1C(F)(F)F | Homo sapiens | CHEMBL3887100 | assay format |
| CHEMBL5428602 |  |
IC50 | = | 1.0 | nM | 381.5 | COc1cc(CNC(=O)CCCc2ccc(-c3ccccc3)s2)ccc1O | Homo sapiens | CHEMBL5342621 | cell-based format |
| CHEMBL5409442 |  |
IC50 | = | 1.02 | nM | 579.62 | O=C(NCc1ccc(C(F)(F)F)nc1N1CCC(Cc2ccccc2)CC1)Nc1cccc2c1ccc(=O)n2CCO | Homo sapiens | CHEMBL5337356 | cell-based format |
| CHEMBL5412992 |  |
IC50 | = | 1.08 | nM | 504.51 | O=C(NCc1ccc(C(F)(F)F)nc1OCC1CCCC1)Nc1cccc2c1ccc(=O)n2CCO | Homo sapiens | CHEMBL5337356 | cell-based format |
| CHEMBL214796 |  |
IC50 | = | 1.1 | nM | 434.34 | FC(F)(F)c1ccc(Nc2ncnc3cc(-c4ncccc4C(F)(F)F)ccc23)cc1 | Homo sapiens | CHEMBL1113609 | single protein format |