Q8NE63 | HIPK4_HUMAN | Homeodomain-interacting protein kinase 4 (HIPK4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 11~347 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4855209 |  |
IC50 | = | 2.8 | nM | 496.5 | CNC(=O)c1cc(Oc2ccc(NC(=O)c3nc(SC)oc3-c3ccc(F)cc3)cc2F)ccn1 | Homo sapiens | CHEMBL4808052 | single protein format |
| CHEMBL4859179 |  |
IC50 | = | 3.3 | nM | 478.51 | CNC(=O)c1cc(Oc2ccc(NC(=O)c3nc(SC)oc3-c3ccc(F)cc3)cc2)ccn1 | Homo sapiens | CHEMBL4808052 | single protein format |
| CHEMBL4850066 |  |
IC50 | = | 5.1 | nM | 526.57 | CNC(=O)c1cc(Oc2ccc(NC(=O)c3nc(S(C)(=O)=O)sc3-c3ccc(F)cc3)cc2)ccn1 | Homo sapiens | CHEMBL4808052 | single protein format |
| CHEMBL4855979 |  |
IC50 | = | 5.2 | nM | 477.52 | CNC(=O)c1cc(Oc2ccc(NC(=O)c3nc(NC)sc3-c3ccc(F)cc3)cc2)ccn1 | Homo sapiens | CHEMBL4808052 | single protein format |
| CHEMBL4870763 |  |
IC50 | = | 9.6 | nM | 516.48 | CNC(=O)c1cc(Oc2ccc(NC(=O)c3nc(C(F)(F)F)sc3-c3ccc(F)cc3)cc2)ccn1 | Homo sapiens | CHEMBL4808052 | single protein format |
| CHEMBL4874174 |  |
IC50 | = | 19.0 | nM | 477.52 | CNC(=O)c1cc(Oc2ccc(NC(=O)c3nc(SC)[nH]c3-c3ccc(F)cc3)cc2)ccn1 | Homo sapiens | CHEMBL4808052 | single protein format |
| CHEMBL4847460 |  |
IC50 | = | 23.0 | nM | 548.64 | CNC(=O)c1cc(Oc2ccc(NC(=O)c3nc(SC)n(CCN(C)C)c3-c3ccc(F)cc3)cc2)ccn1 | Homo sapiens | CHEMBL4808052 | single protein format |
| CHEMBL4875968 |  |
IC50 | = | 32.0 | nM | 553.41 | CSc1nc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3Br)cc2)c(-c2ccc(F)cc2)o1 | Homo sapiens | CHEMBL4808052 | single protein format |
| CHEMBL3103192 |  |
IC50 | = | 40.0 | nM | 419.49 | CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN | Homo sapiens | CHEMBL3810703 | single protein format |
| CHEMBL4853006 |  |
IC50 | = | 49.0 | nM | 432.42 | CNC(=O)c1cc(Oc2ccc(NC(=O)c3n[nH]nc3-c3ccc(F)cc3)cc2)ccn1 | Homo sapiens | CHEMBL4808052 | single protein format |
| CHEMBL91829 |  |
IC50 | = | 100.0 | nM | 468.56 | CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 | Homo sapiens | CHEMBL4739042 | single protein format |
| CHEMBL1336 |  |
IC50 | = | 100.0 | nM | 464.83 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | Homo sapiens | CHEMBL4739042 | single protein format |
| CHEMBL4793380 |  |
IC50 | = | 127.0 | nM | 423.48 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 | Homo sapiens | CHEMBL4767030 | single protein format |
| CHEMBL4439133 |  |
IC50 | = | 176.0 | nM | 388.32 | Cc1n[nH]cc1-c1cc2nc([C@@H]3CCCCN3)[nH]c(=O)c2s1.Cl.Cl | Homo sapiens | CHEMBL4325343 | assay format |
| CHEMBL388978 |  |
IC50 | = | 314.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328447 | single protein format |
| CHEMBL5426285 |  |
IC50 | = | 620.0 | nM | 358.47 | COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 | Homo sapiens | CHEMBL5378519 | single protein format |
| CHEMBL5202142 |  |
IC50 | = | 650.0 | nM | 408.45 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)n2)ccn1 | Homo sapiens | CHEMBL5161249 | single protein format |