Q8NBP7 | PCSK9_HUMAN | Proprotein convertase subtilisin/kexin type 9 (PCSK9)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00082 | Peptidase_S8 - Subtilase family | 181~419 | |
| PF05922 | Inhibitor_I9 - Peptidase inhibitor I9 | 77~149 | |
| PF18459 | PCSK9_C1 - Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain | 450~531 | |
| PF18463 | PCSK9_C3 - Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain | 602~682 | |
| PF18464 | PCSK9_C2 - Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain | 535~600 |
3D structures mapped by conservation among orthologs
[ Domain: "Resistin" // PCSK9_C-CRD_2nd ]
[ Domain: "Resistin" // PCSK9_C-CRD_1st ]
[ Domain: "Resistin" // PCSK9_C-CRD_3rd ]
[ Domain: "Protease propeptides/inhibitors" // Inhibitor_I9 ]
[ Domain: "Subtilisin-like" // Peptidase_S8 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4572783 |  |
IC50 | = | 201.7 | nM | 282.29 | Fc1ccc2[nH]c(Cc3c[nH]c4c(F)cccc34)cc2c1 | Homo sapiens | CHEMBL4434275 | cell-based format |
| CHEMBL4549362 |  |
IC50 | = | 250.0 | nM | 298.75 | Fc1ccc2[nH]c(Cc3c[nH]c4c(Cl)cccc34)cc2c1 | Homo sapiens | CHEMBL4434276 | cell-based format |
| CHEMBL5286553 |  |
IC50 | = | 300.0 | nM | 432.92 | O=C(c1ccc(-n2nnc3ccccc32)cc1)N(c1ncccc1Cl)[C@@H]1CCCNC1 | Homo sapiens | CHEMBL5232231 | single protein format |
| CHEMBL4562557 |  |
IC50 | = | 300.0 | nM | 264.3 | Fc1cccc2c(Cc3cc4ccccc4[nH]3)c[nH]c12 | Homo sapiens | CHEMBL4434276 | cell-based format |
| CHEMBL4107804 |  |
IC50 | = | 440.0 | nM | 412.5 | Cc1cccnc1N(C(=O)c1ccc(-c2cnn3cccnc23)cc1)[C@@H]1CCCNC1 | Homo sapiens | CHEMBL3887821 | cell-based format |
| CHEMBL4458097 |  |
IC50 | = | 500.0 | nM | 473.49 | O=C(Nc1ccc(-c2nc3ccccc3o2)cc1)c1ccc(NC(=O)c2cc3ccccc3o2)cc1 | Homo sapiens | CHEMBL4383971 | single protein format |
| CHEMBL5431139 |  |
IC50 | = | 580.0 | nM | 452.52 | Cn1ccc2ccnc(N(C(=O)c3ccc(-n4nnc5cccnc54)cc3)[C@@H]3CCCNC3)c21 | Homo sapiens | CHEMBL5365867 | cell-based format |
| CHEMBL4109014 |  |
IC50 | = | 592.0 | nM | 573.66 | Cc1cccnc1N(C(=O)c1ccc(-c2cnn(C)c2-c2nnn(C(C)OC(=O)OC(C)C)n2)cc1)[C@@H]1CCCNC1 | Homo sapiens | CHEMBL3887821 | cell-based format |
| CHEMBL5415107 |  |
IC50 | = | 620.0 | nM | 453.51 | Cn1ncc2ccnc(N(C(=O)c3ccc(-n4nnc5cccnc54)cc3)[C@@H]3CCCNC3)c21 | Homo sapiens | CHEMBL5365867 | cell-based format |
| CHEMBL4114106 |  |
IC50 | = | 640.0 | nM | 453.93 | COC(=O)c1c(-c2ccc(C(=O)N(c3ncccc3Cl)[C@@H]3CCCNC3)cc2)cnn1C | Homo sapiens | CHEMBL3887821 | cell-based format |
| CHEMBL4107907 |  |
IC50 | = | 690.0 | nM | 432.92 | O=C(c1ccc(-c2cnn3cccnc23)cc1)N(c1ncccc1Cl)[C@@H]1CCCNC1 | Homo sapiens | CHEMBL3887821 | cell-based format |
| CHEMBL5414787 |  |
IC50 | = | 730.0 | nM | 455.55 | O=C(c1ccc(-n2nnc3cccnc32)cc1)N(c1nccc2ccsc12)[C@@H]1CCCNC1 | Homo sapiens | CHEMBL5365867 | cell-based format |
| CHEMBL4108330 |  |
IC50 | = | 800.0 | nM | 433.51 | COC(=O)c1c(-c2ccc(C(=O)N(c3ncccc3C)[C@@H]3CCCNC3)cc2)cnn1C | Homo sapiens | CHEMBL3887821 | cell-based format |
| CHEMBL4114159 |  |
IC50 | = | 800.0 | nM | 447.93 | Cc1cnc2c(c1)nnn2-c1ccc(C(=O)N(c2ncccc2Cl)[C@@H]2CCCNC2)cc1 | Homo sapiens | CHEMBL3887820 | assay format |
| CHEMBL4109308 |  |
IC50 | = | 800.0 | nM | 433.9 | O=C(c1ccc(-n2nnc3cccnc32)cc1)N(c1ncccc1Cl)[C@@H]1CCCNC1 | Homo sapiens | CHEMBL3887820 | assay format |
| CHEMBL4585306 |  |
IC50 | = | 900.0 | nM | 260.34 | Cc1cccc2c(Cc3cc4ccccc4[nH]3)c[nH]c12 | Homo sapiens | CHEMBL4434276 | cell-based format |
| CHEMBL4126496 |  |
IC50 | = | 900.0 | nM | 447.93 | Cc1ccc2nnn(-c3ccc(C(=O)N(c4ncccc4Cl)[C@@H]4CCCNC4)cc3)c2n1 | Homo sapiens | CHEMBL5036230 | cell-based format |
| CHEMBL31523 |  |
Ki | = | 1000.0 | nM | 162.04 | CCCCB(O)c1ccccc1 | Homo sapiens | CHEMBL813408 | single protein format |