Q8N884 | CGAS_HUMAN | Cyclic GMP-AMP synthase (CGAS)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03281 | Mab-21 - Mab-21 protein nucleotidyltransferase domain | 214~389 | |
| PF20266 | Mab-21_C - Mab-21 protein HhH/H2TH-like domain | 405~509 |
3D structures mapped by conservation among orthologs
[ Domain: "PAP/OAS1 substrate-binding domain" // Mab-21_C ]
[ Domain: "Nucleotidyltransferase" // Mab-21_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL323197 |  |
IC50 | = | 4.0 | nM | 410.47 | COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C | Homo sapiens | CHEMBL4373771 | single protein format |
| CHEMBL4448176 |  |
IC50 | = | 10.2 | nM | 391.26 | Nc1ccc(-c2cc(Cl)c(Cl)c3[nH]c4c(c23)CN(C(=O)CO)CC4)cn1 | Homo sapiens | CHEMBL4373755 | single protein format |
| CHEMBL5174318 |  |
IC50 | = | 14.0 | nM | 379.25 | Cn1cc(-c2cc(Cl)c(Cl)c3[nH]c4c(c23)CN(C(=O)CO)CC4)cn1 | Homo sapiens | CHEMBL5109083 | single protein format |
| CHEMBL5082056 |  |
IC50 | = | 14.0 | nM | 379.25 | Cn1ccc(-c2cc(Cl)c(Cl)c3[nH]c4c(c23)CN(C(=O)CO)CC4)n1 | Homo sapiens | CHEMBL5040038 | single protein format |
| CHEMBL5081956 |  |
IC50 | = | 27.0 | nM | 365.22 | O=C(CO)N1CCc2[nH]c3c(Cl)c(Cl)cc(-c4cn[nH]c4)c3c2C1 | Homo sapiens | CHEMBL5040038 | single protein format |
| CHEMBL5203275 |  |
IC50 | = | 30.0 | nM | 313.38 | O=C1N=C(N2CCCCC2)S/C1=C1/C(=O)Nc2ccccc21 | Homo sapiens | CHEMBL5109081 | single protein format |
| CHEMBL577784 |  |
IC50 | = | 60.0 | nM | 591.48 | O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I)c1cccs1 | Homo sapiens | CHEMBL4031182 | cell-based format |
| CHEMBL5206813 |  |
IC50 | = | 70.0 | nM | 328.75 | O=C(COc1ccc(Cl)c2ccccc12)Nc1ncccc1O | Homo sapiens | CHEMBL5109081 | single protein format |
| CHEMBL5207488 |  |
IC50 | = | 100.0 | nM | 309.29 | O=C(Nc1cc(-c2ccccc2)ccn1)c1[nH]ncc1[N+](=O)[O-] | Homo sapiens | CHEMBL5097704 | assay format |
| CHEMBL4567157 |  |
IC50 | = | 110.0 | nM | 415.24 | Cc1nn(-c2nc3ccc(Cl)c(Cl)c3[nH]2)c(O)c1C1OC(=O)c2ccccc21 | Homo sapiens | CHEMBL5109081 | single protein format |
| CHEMBL5076595 |  |
IC50 | = | 240.0 | nM | 407.12 | COC(=O)c1nc(N)nc(Nc2cc(F)c(I)c(F)c2)n1 | Homo sapiens | CHEMBL5040037 | single protein format |
| CHEMBL5206893 |  |
IC50 | = | 391.0 | nM | 259.7 | COc1cc2c(-n3ccnc3)ccnc2cc1Cl | Homo sapiens | CHEMBL5097713 | single protein format |
| CHEMBL4553806 |  |
IC50 | <= | 500.0 | nM | 528.39 | CN1C(=O)S/C(=C\c2cc(OCc3cnc(NCc4ccncc4)nc3)c(O)cc2Br)C1=O | Homo sapiens | CHEMBL4418453 | cell-based format |
| CHEMBL4594128 |  |
IC50 | <= | 500.0 | nM | 422.26 | CN1C(=O)S/C(=C\c2cc(OCc3cncnc3)c(O)cc2Br)C1=O | Homo sapiens | CHEMBL4418453 | cell-based format |
| CHEMBL4515256 |  |
IC50 | <= | 500.0 | nM | 437.28 | CN1C(=O)S/C(=C\c2cc(OCc3cncnc3N)c(O)cc2Br)C1=O | Homo sapiens | CHEMBL4418453 | cell-based format |
| CHEMBL4454103 |  |
IC50 | <= | 500.0 | nM | 436.29 | Cc1ncc(COc2cc(/C=C3\SC(=O)N(C)C3=O)c(Br)cc2O)cn1 | Homo sapiens | CHEMBL4418453 | cell-based format |
| CHEMBL4471905 |  |
IC50 | <= | 500.0 | nM | 499.35 | CN1C(=O)S/C(=C\c2cc(OCc3cnc(-c4ccncc4)nc3)c(O)cc2Br)C1=O | Homo sapiens | CHEMBL4418453 | cell-based format |
| CHEMBL4438200 |  |
IC50 | <= | 500.0 | nM | 437.28 | CN1C(=O)S/C(=C\c2cc(OCc3cnc(N)nc3)c(O)cc2Br)C1=O | Homo sapiens | CHEMBL4418453 | cell-based format |
| CHEMBL4445255 |  |
IC50 | <= | 500.0 | nM | 451.3 | CNc1ncc(COc2cc(/C=C3\SC(=O)N(C)C3=O)c(Br)cc2O)cn1 | Homo sapiens | CHEMBL4418453 | cell-based format |
| CHEMBL4573379 |  |
IC50 | <= | 500.0 | nM | 499.32 | CN1C(=O)S/C(=C\c2cc(OCc3cnc(NCCO)nc3)c(O)c(F)c2Br)C1=O | Homo sapiens | CHEMBL4418453 | cell-based format |