Q8N4C8 | MINK1_HUMAN | Misshapen-like kinase 1 (MINK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 25~289 | |
| PF00780 | CNH - CNH domain | 1028~1301 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 0.49 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL973449 | single protein format |
| CHEMBL4746566 |  |
IC50 | = | 1.3 | nM | 382.85 | CC(C)(Oc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cc1)C(=O)O | Homo sapiens | CHEMBL4681969 | single protein format |
| CHEMBL4568087 |  |
IC50 | = | 6.0 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479752 | assay format |
| CHEMBL3754515 |  |
IC50 | = | 8.0 | nM | 296.76 | Nc1ccc(-c2cnc(N)c(-c3ccc(Cl)cc3)c2)cn1 | Homo sapiens | CHEMBL3755435 | single protein format |
| CHEMBL4569508 |  |
IC50 | = | 13.0 | nM | 529.59 | O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 | Homo sapiens | CHEMBL4479752 | assay format |
| CHEMBL288441 |  |
IC50 | = | 22.0 | nM | 530.46 | COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl | Homo sapiens | CHEMBL1244339 | single protein format |
| CHEMBL4550702 |  |
IC50 | = | 22.0 | nM | 406.39 | Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479752 | assay format |
| CHEMBL103667 |  |
IC50 | = | 40.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL1931511 | single protein format |
| CHEMBL4877846 |  |
IC50 | = | 90.73 | nM | 566.71 | Cc1nn(C(C)C)c(C)c1-c1nc2c(-c3ccc4c(c3)CCCC[C@H]4NC(=O)c3nc(C(C)(C)C)no3)ccnc2[nH]1 | Homo sapiens | CHEMBL4822493 | single protein format |
| CHEMBL2011291 |  |
IC50 | = | 99.0 | nM | 433.7 | Nc1c(-c2ccc(F)cc2)c(-c2ccncc2)nn1-c1c(Cl)cc(Cl)cc1Cl | Homo sapiens | CHEMBL3888891 | cell-based format |
| CHEMBL5086263 |  |
IC50 | = | 115.0 | nM | 486.43 | CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O | Homo sapiens | CHEMBL5046173 | single protein format |
| CHEMBL4552628 |  |
IC50 | = | 140.0 | nM | 425.89 | Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 | Homo sapiens | CHEMBL4479752 | assay format |
| CHEMBL3262590 |  |
IC50 | = | 150.0 | nM | 241.23 | Nc1ncnc2ccc(-c3ccnc(F)c3)nc12 | Homo sapiens | CHEMBL4434085 | cell-based format |
| CHEMBL4517408 |  |
IC50 | = | 336.0 | nM | 419.53 | COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1OC | Homo sapiens | CHEMBL4626196 | single protein format |
| CHEMBL4475494 |  |
IC50 | = | 879.0 | nM | 482.52 | CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O | Homo sapiens | CHEMBL4886039 | single protein format |