Q8N474 | SFRP1_HUMAN | Secreted frizzled-related protein 1 (SFRP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01392 | Fz - Fz domain | 61~163 | |
| PF01759 | NTR - UNC-6/NTR/C345C module | 200~295 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL495534 |  |
IC50 | = | 30.0 | nM | 556.59 | O=C(Cn1ccnc1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1011781 | single protein format |
| CHEMBL606033 |  |
IC50 | = | 40.0 | nM | 596.65 | CN(C)c1ccc(C(=O)N2CCC(NS(=O)(=O)c3cc(S(=O)(=O)c4ccccc4)ccc3C(F)(F)F)CC2)cn1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL592670 |  |
IC50 | = | 40.0 | nM | 545.61 | O=C([C@H]1CCNC1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL591482 |  |
IC50 | = | 60.0 | nM | 545.61 | O=C([C@@H]1CCNC1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL589066 |  |
IC50 | = | 60.0 | nM | 553.58 | O=C(c1ccccn1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL603165 |  |
IC50 | = | 60.0 | nM | 505.54 | NC(=O)CN1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL589088 |  |
IC50 | = | 70.0 | nM | 552.6 | O=C(c1ccccc1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL589067 |  |
IC50 | = | 80.0 | nM | 553.58 | O=C(c1cccnc1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL525899 |  |
IC50 | = | 90.0 | nM | 559.59 | O=C1CC[C@@H](C(=O)N2CCC(NS(=O)(=O)c3cc(S(=O)(=O)c4ccccc4)ccc3C(F)(F)F)CC2)N1 | Homo sapiens | CHEMBL1011781 | single protein format |
| CHEMBL589559 |  |
IC50 | = | 100.0 | nM | 573.66 | O=C(CC1CCNCC1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL523726 |  |
IC50 | = | 100.0 | nM | 575.63 | O=C(CN1CCOCC1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1011781 | single protein format |
| CHEMBL591035 |  |
IC50 | = | 100.0 | nM | 568.6 | O=C(O)c1cccc(N2CCC(NS(=O)(=O)c3cc(S(=O)(=O)c4ccccc4)ccc3C(F)(F)F)CC2)c1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL495526 |  |
IC50 | = | 110.0 | nM | 559.63 | O=C(CN1CCCC1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1011781 | single protein format |
| CHEMBL495535 |  |
IC50 | = | 110.0 | nM | 545.61 | O=C([C@@H]1CCCN1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1011781 | single protein format |
| CHEMBL605196 |  |
IC50 | = | 110.0 | nM | 588.03 | O=C(c1ccc(Cl)nc1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL496581 |  |
IC50 | = | 120.0 | nM | 559.63 | CN1CCC[C@H]1C(=O)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1011781 | single protein format |
| CHEMBL591064 |  |
IC50 | = | 120.0 | nM | 568.6 | O=C(O)c1ccc(N2CCC(NS(=O)(=O)c3cc(S(=O)(=O)c4ccccc4)ccc3C(F)(F)F)CC2)cc1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL591017 |  |
IC50 | = | 120.0 | nM | 559.63 | O=C(C1CCNCC1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL589363 |  |
IC50 | = | 130.0 | nM | 588.65 | O=S(=O)(NC1CCN(S(=O)(=O)c2ccccc2)CC1)c1cc(S(=O)(=O)c2ccccc2)ccc1C(F)(F)F | Homo sapiens | CHEMBL1072833 | single protein format |
| CHEMBL525718 |  |
IC50 | = | 140.0 | nM | 574.65 | O=C(CN1CCNCC1)N1CCC(NS(=O)(=O)c2cc(S(=O)(=O)c3ccccc3)ccc2C(F)(F)F)CC1 | Homo sapiens | CHEMBL1011781 | single protein format |