Q8IYT8 | ULK2_HUMAN | Serine/threonine-protein kinase ULK2 (ULK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 9~271 | |
| PF12063 | ATG1-like_MIT1 - Atg1-like, MIT domain 1 | 863~945 | |
| PF21127 | ATG1-like_MIT2 - ATG1-like, MIT domain 2 | 956~1029 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4516990 |  |
IC50 | = | 1.1 | nM | 434.59 | CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CCC4)n3)ccc2C1 | Homo sapiens | CHEMBL4308984 | single protein format |
| CHEMBL5266681 |  |
IC50 | = | 1.1 | nM | 450.59 | O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CC1 | Homo sapiens | CHEMBL5250360 | single protein format |
| CHEMBL5280560 |  |
IC50 | = | 2.6 | nM | 573.68 | CC(C)[C@H](NC(=O)c1cc(C2C=C3N=C(c4ccc(OCCN5CCCCC5)cc4)C=CN3N2)cs1)C(F)(F)F | Homo sapiens | CHEMBL5250360 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 2.67 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328648 | single protein format |
| CHEMBL3605055 |  |
IC50 | = | 13.0 | nM | 396.46 | c1ccc2c(Nc3cc(C4CCC4)[nH]n3)nc(Nc3ccc4[nH]cnc4c3)nc2c1 | Homo sapiens | CHEMBL3606872 | cell-based format |
| CHEMBL5269042 |  |
IC50 | = | 30.0 | nM | 462.47 | O=C(N[C@@H](C1CC1)C(F)(F)F)c1cc(C2C=C3N=C(c4ccc(F)cc4)C=CN3N2)cs1 | Homo sapiens | CHEMBL5250360 | single protein format |
| CHEMBL5288376 |  |
IC50 | = | 38.0 | nM | 420.56 | CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=O)C4CC4)n3)ccc2C1 | Homo sapiens | CHEMBL5250360 | single protein format |
| CHEMBL4127042 |  |
IC50 | = | 38.0 | nM | 433.6 | CN1CCc2cc(Nc3ncc(C4CC4)c(NCCCNC(=N)C4CCC4)n3)ccc2C1 | Homo sapiens | CHEMBL4121193 | single protein format |
| CHEMBL4554938 |  |
IC50 | = | 41.5 | nM | 416.49 | CN1C(=O)c2sccc2N(C)c2nc(Nc3ccc(S(N)(=O)=O)cc3)ncc21 | Homo sapiens | CHEMBL5212978 | single protein format |
| CHEMBL3603853 |  |
IC50 | = | 200.0 | nM | 549.42 | O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I)C1CC1 | Homo sapiens | CHEMBL3606872 | cell-based format |
| CHEMBL3605057 |  |
IC50 | = | 230.0 | nM | 464.61 | O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1 | Homo sapiens | CHEMBL3606872 | cell-based format |
| CHEMBL577784 |  |
IC50 | = | 310.0 | nM | 591.48 | O=C(NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I)c1cccs1 | Homo sapiens | CHEMBL3606872 | cell-based format |
| CHEMBL3605056 |  |
IC50 | = | 360.0 | nM | 481.34 | NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1I | Homo sapiens | CHEMBL3606872 | cell-based format |
| CHEMBL4779423 |  |
IC50 | = | 476.0 | nM | 354.33 | COc1ccc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)cc1OC | Homo sapiens | CHEMBL4677635 | cell-based format |
| CHEMBL4795918 |  |
IC50 | = | 695.0 | nM | 325.29 | COc1cncc(Nc2ncc(C(F)(F)F)c(NC3CC3)n2)c1 | Homo sapiens | CHEMBL4677635 | cell-based format |
| CHEMBL4128069 |  |
IC50 | = | 711.0 | nM | 489.33 | CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br | Homo sapiens | CHEMBL4121193 | single protein format |
| CHEMBL4746440 |  |
IC50 | = | 714.0 | nM | 345.33 | FC(F)(F)c1cnc(Nc2ccc3ncccc3c2)nc1NC1CC1 | Homo sapiens | CHEMBL4677635 | cell-based format |
| CHEMBL4741912 |  |
IC50 | = | 720.0 | nM | 334.31 | FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1NC1CC1 | Homo sapiens | CHEMBL4677635 | cell-based format |